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Gene: ZPR1 |
Gene summary for ZPR1 |
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Gene information | Species | Human | Gene symbol | ZPR1 | Gene ID | 8882 |
Gene name | ZPR1 zinc finger | |
Gene Alias | GKAF | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | O75312 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8882 | ZPR1 | P54T-E | Human | Esophagus | ESCC | 1.33e-22 | 6.18e-01 | 0.0975 |
8882 | ZPR1 | P56T-E | Human | Esophagus | ESCC | 1.87e-03 | 7.08e-01 | 0.1613 |
8882 | ZPR1 | P57T-E | Human | Esophagus | ESCC | 4.22e-13 | 2.98e-01 | 0.0926 |
8882 | ZPR1 | P61T-E | Human | Esophagus | ESCC | 7.94e-10 | 1.43e-01 | 0.099 |
8882 | ZPR1 | P62T-E | Human | Esophagus | ESCC | 1.89e-52 | 1.04e+00 | 0.1302 |
8882 | ZPR1 | P65T-E | Human | Esophagus | ESCC | 5.05e-13 | 2.35e-01 | 0.0978 |
8882 | ZPR1 | P74T-E | Human | Esophagus | ESCC | 4.81e-39 | 1.04e+00 | 0.1479 |
8882 | ZPR1 | P75T-E | Human | Esophagus | ESCC | 7.80e-59 | 1.34e+00 | 0.1125 |
8882 | ZPR1 | P76T-E | Human | Esophagus | ESCC | 4.69e-14 | 3.04e-01 | 0.1207 |
8882 | ZPR1 | P79T-E | Human | Esophagus | ESCC | 2.15e-24 | 5.28e-01 | 0.1154 |
8882 | ZPR1 | P80T-E | Human | Esophagus | ESCC | 1.59e-53 | 1.83e+00 | 0.155 |
8882 | ZPR1 | P82T-E | Human | Esophagus | ESCC | 4.87e-11 | 5.97e-01 | 0.1072 |
8882 | ZPR1 | P83T-E | Human | Esophagus | ESCC | 2.78e-32 | 1.06e+00 | 0.1738 |
8882 | ZPR1 | P89T-E | Human | Esophagus | ESCC | 1.31e-11 | 1.46e+00 | 0.1752 |
8882 | ZPR1 | P91T-E | Human | Esophagus | ESCC | 8.81e-10 | 1.20e+00 | 0.1828 |
8882 | ZPR1 | P107T-E | Human | Esophagus | ESCC | 9.87e-35 | 8.85e-01 | 0.171 |
8882 | ZPR1 | P126T-E | Human | Esophagus | ESCC | 3.90e-03 | 5.85e-01 | 0.1125 |
8882 | ZPR1 | P127T-E | Human | Esophagus | ESCC | 1.51e-18 | 1.51e-01 | 0.0826 |
8882 | ZPR1 | P128T-E | Human | Esophagus | ESCC | 1.60e-31 | 1.14e+00 | 0.1241 |
8882 | ZPR1 | P130T-E | Human | Esophagus | ESCC | 3.78e-33 | 9.01e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZPR1 | SNV | Missense_Mutation | rs148642555 | c.1376N>A | p.Arg459Gln | p.R459Q | O75312 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.978) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ZPR1 | SNV | Missense_Mutation | novel | c.1170N>T | p.Lys390Asn | p.K390N | O75312 | protein_coding | deleterious(0.04) | probably_damaging(0.923) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZPR1 | SNV | Missense_Mutation | novel | c.346N>A | p.Glu116Lys | p.E116K | O75312 | protein_coding | deleterious(0.02) | benign(0.41) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
ZPR1 | SNV | Missense_Mutation | novel | c.509C>T | p.Ala170Val | p.A170V | O75312 | protein_coding | deleterious(0.05) | benign(0.053) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZPR1 | SNV | Missense_Mutation | c.233N>C | p.Phe78Ser | p.F78S | O75312 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZPR1 | SNV | Missense_Mutation | c.521N>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZPR1 | SNV | Missense_Mutation | novel | c.763N>C | p.Phe255Leu | p.F255L | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.694) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
ZPR1 | SNV | Missense_Mutation | c.521G>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZPR1 | SNV | Missense_Mutation | rs529843898 | c.796N>A | p.Ala266Thr | p.A266T | O75312 | protein_coding | tolerated(0.16) | benign(0.095) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
ZPR1 | SNV | Missense_Mutation | c.521N>T | p.Arg174Ile | p.R174I | O75312 | protein_coding | deleterious(0) | possibly_damaging(0.465) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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