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Gene: ZNF83 |
Gene summary for ZNF83 |
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Gene information | Species | Human | Gene symbol | ZNF83 | Gene ID | 55769 |
Gene name | zinc finger protein 83 | |
Gene Alias | HPF1 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4L3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55769 | ZNF83 | P127T-E | Human | Esophagus | ESCC | 1.23e-14 | 2.57e-01 | 0.0826 |
55769 | ZNF83 | P128T-E | Human | Esophagus | ESCC | 1.40e-11 | 5.69e-01 | 0.1241 |
55769 | ZNF83 | P130T-E | Human | Esophagus | ESCC | 9.18e-12 | 2.68e-01 | 0.1676 |
55769 | ZNF83 | HCC1_Meng | Human | Liver | HCC | 1.89e-20 | -1.30e-01 | 0.0246 |
55769 | ZNF83 | cirrhotic1 | Human | Liver | Cirrhotic | 6.20e-07 | 2.15e-01 | 0.0202 |
55769 | ZNF83 | cirrhotic2 | Human | Liver | Cirrhotic | 1.56e-04 | 1.14e-01 | 0.0201 |
55769 | ZNF83 | HCC1 | Human | Liver | HCC | 1.43e-02 | 3.13e+00 | 0.5336 |
55769 | ZNF83 | HCC2 | Human | Liver | HCC | 2.84e-10 | 3.37e+00 | 0.5341 |
55769 | ZNF83 | RNA-P17T-P17T-2 | Human | Lung | IAC | 7.20e-05 | 8.62e-01 | 0.3371 |
55769 | ZNF83 | RNA-P17T-P17T-4 | Human | Lung | IAC | 5.42e-09 | 9.70e-01 | 0.343 |
55769 | ZNF83 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.97e-08 | 1.06e+00 | 0.3385 |
55769 | ZNF83 | RNA-P17T-P17T-8 | Human | Lung | IAC | 6.35e-06 | 7.79e-01 | 0.3329 |
55769 | ZNF83 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.87e-03 | 2.54e-01 | -0.0166 |
55769 | ZNF83 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.87e-04 | 2.63e-01 | -0.0132 |
55769 | ZNF83 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.70e-05 | 2.63e-01 | -0.013 |
55769 | ZNF83 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.08e-02 | 5.77e-01 | -0.0822 |
55769 | ZNF83 | HTA12-23-1 | Human | Pancreas | PDAC | 6.98e-03 | 5.55e-01 | 0.3405 |
55769 | ZNF83 | HTA12-26-1 | Human | Pancreas | PDAC | 1.39e-08 | 5.17e-01 | 0.3728 |
55769 | ZNF83 | HTA12-29-1 | Human | Pancreas | PDAC | 3.81e-14 | 4.39e-01 | 0.3722 |
55769 | ZNF83 | HTA12-9-2 | Human | Pancreas | PDAC | 4.48e-04 | 3.98e-01 | 0.0835 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00000864 | Esophagus | ESCC | G2/M transition of mitotic cell cycle | 96/8552 | 137/18723 | 6.00e-09 | 1.23e-07 | 96 |
GO:00070934 | Esophagus | ESCC | mitotic cell cycle checkpoint | 90/8552 | 129/18723 | 2.49e-08 | 4.69e-07 | 90 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:00062612 | Esophagus | ESCC | DNA-dependent DNA replication | 100/8552 | 151/18723 | 2.61e-07 | 3.94e-06 | 100 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF83 | SNV | Missense_Mutation | novel | c.649N>T | p.Ile217Phe | p.I217F | P51522 | protein_coding | tolerated(0.68) | benign(0.181) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF83 | SNV | Missense_Mutation | c.1010N>A | p.Arg337Lys | p.R337K | P51522 | protein_coding | tolerated(0.18) | probably_damaging(0.994) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
ZNF83 | SNV | Missense_Mutation | c.205N>G | p.His69Asp | p.H69D | P51522 | protein_coding | tolerated(0.08) | benign(0.031) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
ZNF83 | SNV | Missense_Mutation | novel | c.250N>A | p.Glu84Lys | p.E84K | P51522 | protein_coding | deleterious(0.05) | benign(0.143) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF83 | SNV | Missense_Mutation | c.573N>A | p.His191Gln | p.H191Q | P51522 | protein_coding | tolerated(0.27) | possibly_damaging(0.54) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF83 | SNV | Missense_Mutation | c.942G>C | p.Glu314Asp | p.E314D | P51522 | protein_coding | deleterious(0.01) | possibly_damaging(0.713) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF83 | SNV | Missense_Mutation | c.173N>A | p.Arg58His | p.R58H | P51522 | protein_coding | deleterious(0) | benign(0.425) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF83 | SNV | Missense_Mutation | c.1336C>A | p.His446Asn | p.H446N | P51522 | protein_coding | tolerated(0.66) | possibly_damaging(0.542) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF83 | SNV | Missense_Mutation | rs762225164 | c.503G>A | p.Arg168His | p.R168H | P51522 | protein_coding | tolerated(0.17) | probably_damaging(0.986) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF83 | SNV | Missense_Mutation | c.648A>C | p.Gln216His | p.Q216H | P51522 | protein_coding | tolerated(0.17) | possibly_damaging(0.816) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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