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Gene: ZNF827 |
Gene summary for ZNF827 |
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Gene information | Species | Human | Gene symbol | ZNF827 | Gene ID | 152485 |
Gene name | zinc finger protein 827 | |
Gene Alias | ZNF827 | |
Cytomap | 4q31.21-q31.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KSR1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152485 | ZNF827 | P79T-E | Human | Esophagus | ESCC | 7.70e-18 | 3.02e-01 | 0.1154 |
152485 | ZNF827 | P80T-E | Human | Esophagus | ESCC | 3.81e-14 | 4.10e-01 | 0.155 |
152485 | ZNF827 | P82T-E | Human | Esophagus | ESCC | 3.99e-07 | 3.43e-01 | 0.1072 |
152485 | ZNF827 | P83T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.22e-01 | 0.1738 |
152485 | ZNF827 | P84T-E | Human | Esophagus | ESCC | 4.26e-03 | 2.01e-01 | 0.0933 |
152485 | ZNF827 | P89T-E | Human | Esophagus | ESCC | 2.79e-02 | 1.52e-01 | 0.1752 |
152485 | ZNF827 | P91T-E | Human | Esophagus | ESCC | 1.41e-03 | 4.34e-01 | 0.1828 |
152485 | ZNF827 | P107T-E | Human | Esophagus | ESCC | 7.76e-04 | 1.25e-01 | 0.171 |
152485 | ZNF827 | P127T-E | Human | Esophagus | ESCC | 1.19e-13 | 1.07e-01 | 0.0826 |
152485 | ZNF827 | P128T-E | Human | Esophagus | ESCC | 1.19e-09 | 3.77e-01 | 0.1241 |
152485 | ZNF827 | P130T-E | Human | Esophagus | ESCC | 2.33e-11 | 2.84e-01 | 0.1676 |
152485 | ZNF827 | HTA12-23-1 | Human | Pancreas | PDAC | 2.35e-03 | 6.46e-01 | 0.3405 |
152485 | ZNF827 | HTA12-25-1 | Human | Pancreas | PDAC | 1.10e-02 | 4.66e-01 | 0.313 |
152485 | ZNF827 | HTA12-26-1 | Human | Pancreas | PDAC | 1.35e-08 | 5.71e-01 | 0.3728 |
152485 | ZNF827 | HTA12-29-1 | Human | Pancreas | PDAC | 7.25e-27 | 6.43e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF827 | SNV | Missense_Mutation | c.1913G>A | p.Gly638Glu | p.G638E | Q17R98 | protein_coding | deleterious(0.03) | benign(0.048) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
ZNF827 | SNV | Missense_Mutation | rs772895087 | c.1471N>A | p.Glu491Lys | p.E491K | Q17R98 | protein_coding | deleterious_low_confidence(0.01) | benign(0.052) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNF827 | SNV | Missense_Mutation | novel | c.1022N>T | p.Pro341Leu | p.P341L | Q17R98 | protein_coding | tolerated_low_confidence(0.07) | benign(0.003) | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZNF827 | SNV | Missense_Mutation | c.1425N>C | p.Lys475Asn | p.K475N | Q17R98 | protein_coding | deleterious(0) | possibly_damaging(0.666) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF827 | SNV | Missense_Mutation | novel | c.1747G>T | p.Ala583Ser | p.A583S | Q17R98 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EW-A6SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | aromatase | SD |
ZNF827 | SNV | Missense_Mutation | c.2137G>C | p.Glu713Gln | p.E713Q | Q17R98 | protein_coding | tolerated(0.06) | possibly_damaging(0.474) | TCGA-GM-A2DO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
ZNF827 | insertion | Frame_Shift_Ins | novel | c.2716_2717insTAACTTACAGAATCCCTATTAACAAATCAGCCCTAGAAAAG | p.Thr906IlefsTer53 | p.T906Ifs*53 | Q17R98 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF827 | insertion | Frame_Shift_Ins | novel | c.1808_1809insT | p.Glu604GlyfsTer19 | p.E604Gfs*19 | Q17R98 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF827 | insertion | Nonsense_Mutation | novel | c.1807_1808insATTACTTGGCTTAAATTCCTGTGTTGTGT | p.Gly603AspfsTer5 | p.G603Dfs*5 | Q17R98 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF827 | insertion | Nonsense_Mutation | novel | c.2590_2591insAGATTGCTTAATGAACTGATT | p.His863_Leu864insTer | p.H863_L864ins* | Q17R98 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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