![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF750 |
Gene summary for ZNF750 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF750 | Gene ID | 79755 |
Gene name | zinc finger protein 750 | |
Gene Alias | ZFP750 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q32MQ0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79755 | ZNF750 | P126T-E | Human | Esophagus | ESCC | 5.34e-06 | 9.02e-01 | 0.1125 |
79755 | ZNF750 | P127T-E | Human | Esophagus | ESCC | 3.11e-33 | 9.06e-01 | 0.0826 |
79755 | ZNF750 | P128T-E | Human | Esophagus | ESCC | 6.70e-40 | 1.66e+00 | 0.1241 |
79755 | ZNF750 | P130T-E | Human | Esophagus | ESCC | 2.50e-26 | 1.21e+00 | 0.1676 |
79755 | ZNF750 | C38 | Human | Oral cavity | OSCC | 2.43e-07 | 1.23e+00 | 0.172 |
79755 | ZNF750 | C43 | Human | Oral cavity | OSCC | 6.75e-33 | 7.84e-01 | 0.1704 |
79755 | ZNF750 | C57 | Human | Oral cavity | OSCC | 1.94e-21 | 6.92e-01 | 0.1679 |
79755 | ZNF750 | C08 | Human | Oral cavity | OSCC | 3.80e-18 | 6.73e-01 | 0.1919 |
79755 | ZNF750 | LN22 | Human | Oral cavity | OSCC | 1.24e-03 | 7.69e-01 | 0.1733 |
79755 | ZNF750 | LN46 | Human | Oral cavity | OSCC | 2.07e-03 | 3.93e-01 | 0.1666 |
79755 | ZNF750 | SYSMH1 | Human | Oral cavity | OSCC | 7.01e-11 | 4.04e-01 | 0.1127 |
79755 | ZNF750 | SYSMH2 | Human | Oral cavity | OSCC | 1.57e-05 | 3.41e-01 | 0.2326 |
79755 | ZNF750 | SYSMH3 | Human | Oral cavity | OSCC | 1.71e-02 | 2.71e-01 | 0.2442 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00107174 | Esophagus | ESCC | regulation of epithelial to mesenchymal transition | 61/8552 | 99/18723 | 1.01e-03 | 5.09e-03 | 61 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00018377 | Oral cavity | OSCC | epithelial to mesenchymal transition | 82/7305 | 157/18723 | 5.09e-04 | 2.98e-03 | 82 |
GO:00107173 | Oral cavity | OSCC | regulation of epithelial to mesenchymal transition | 54/7305 | 99/18723 | 1.21e-03 | 6.10e-03 | 54 |
GO:00487627 | Oral cavity | OSCC | mesenchymal cell differentiation | 109/7305 | 236/18723 | 1.43e-02 | 4.69e-02 | 109 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF750 | SNV | Missense_Mutation | novel | c.215N>G | p.Asp72Gly | p.D72G | Q32MQ0 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF750 | SNV | Missense_Mutation | novel | c.1180N>A | p.Asp394Asn | p.D394N | Q32MQ0 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZNF750 | insertion | Frame_Shift_Ins | novel | c.1614_1615insTATTTTC | p.Glu539TyrfsTer24 | p.E539Yfs*24 | Q32MQ0 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF750 | deletion | Frame_Shift_Del | novel | c.2095delN | p.Gln699SerfsTer85 | p.Q699Sfs*85 | Q32MQ0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF750 | SNV | Missense_Mutation | c.40N>G | p.Tyr14Asp | p.Y14D | Q32MQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
ZNF750 | SNV | Missense_Mutation | c.1896N>C | p.Gln632His | p.Q632H | Q32MQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF750 | SNV | Missense_Mutation | c.40N>G | p.Tyr14Asp | p.Y14D | Q32MQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF750 | SNV | Missense_Mutation | c.362N>A | p.Gly121Glu | p.G121E | Q32MQ0 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ZNF750 | SNV | Missense_Mutation | c.118N>G | p.Leu40Val | p.L40V | Q32MQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ZNF750 | SNV | Missense_Mutation | c.668N>T | p.Ser223Leu | p.S223L | Q32MQ0 | protein_coding | deleterious(0) | benign(0.229) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |