![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF680 |
Gene summary for ZNF680 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF680 | Gene ID | 340252 |
Gene name | zinc finger protein 680 | |
Gene Alias | ZNF680 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NEM1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
340252 | ZNF680 | P79T-E | Human | Esophagus | ESCC | 8.31e-13 | 2.53e-01 | 0.1154 |
340252 | ZNF680 | P80T-E | Human | Esophagus | ESCC | 6.62e-08 | 2.02e-01 | 0.155 |
340252 | ZNF680 | P83T-E | Human | Esophagus | ESCC | 2.43e-27 | 7.33e-01 | 0.1738 |
340252 | ZNF680 | P89T-E | Human | Esophagus | ESCC | 3.17e-09 | 4.75e-01 | 0.1752 |
340252 | ZNF680 | P91T-E | Human | Esophagus | ESCC | 1.45e-05 | 5.22e-01 | 0.1828 |
340252 | ZNF680 | P107T-E | Human | Esophagus | ESCC | 3.21e-04 | 9.37e-02 | 0.171 |
340252 | ZNF680 | P127T-E | Human | Esophagus | ESCC | 2.12e-05 | 1.28e-01 | 0.0826 |
340252 | ZNF680 | P128T-E | Human | Esophagus | ESCC | 6.71e-07 | 2.94e-01 | 0.1241 |
340252 | ZNF680 | male-WTA | Human | Thyroid | PTC | 9.32e-16 | 7.13e-02 | 0.1037 |
340252 | ZNF680 | PTC01 | Human | Thyroid | PTC | 4.85e-09 | 2.75e-01 | 0.1899 |
340252 | ZNF680 | PTC03 | Human | Thyroid | PTC | 3.09e-03 | 1.65e-01 | 0.1784 |
340252 | ZNF680 | PTC04 | Human | Thyroid | PTC | 1.65e-19 | 3.36e-01 | 0.1927 |
340252 | ZNF680 | PTC05 | Human | Thyroid | PTC | 8.30e-25 | 8.48e-01 | 0.2065 |
340252 | ZNF680 | PTC06 | Human | Thyroid | PTC | 7.12e-30 | 6.63e-01 | 0.2057 |
340252 | ZNF680 | PTC07 | Human | Thyroid | PTC | 9.69e-28 | 5.34e-01 | 0.2044 |
340252 | ZNF680 | ATC11 | Human | Thyroid | ATC | 1.04e-04 | 4.81e-01 | 0.3386 |
340252 | ZNF680 | ATC12 | Human | Thyroid | ATC | 2.81e-11 | 2.76e-01 | 0.34 |
340252 | ZNF680 | ATC13 | Human | Thyroid | ATC | 2.55e-44 | 8.35e-01 | 0.34 |
340252 | ZNF680 | ATC3 | Human | Thyroid | ATC | 1.41e-06 | 5.91e-01 | 0.338 |
340252 | ZNF680 | ATC4 | Human | Thyroid | ATC | 5.29e-16 | 3.62e-01 | 0.34 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF680 | SNV | Missense_Mutation | novel | c.968A>C | p.Lys323Thr | p.K323T | Q8NEM1 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | novel | c.490C>A | p.His164Asn | p.H164N | Q8NEM1 | protein_coding | tolerated(0.13) | benign(0.065) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | rs376623323 | c.1502G>A | p.Arg501Gln | p.R501Q | Q8NEM1 | protein_coding | tolerated(1) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF680 | SNV | Missense_Mutation | novel | c.899N>G | p.His300Arg | p.H300R | Q8NEM1 | protein_coding | deleterious(0.01) | benign(0.359) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.898N>G | p.His300Asp | p.H300D | Q8NEM1 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF680 | SNV | Missense_Mutation | novel | c.920C>T | p.Ala307Val | p.A307V | Q8NEM1 | protein_coding | deleterious(0) | benign(0.058) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | novel | c.1523A>T | p.His508Leu | p.H508L | Q8NEM1 | protein_coding | deleterious(0) | possibly_damaging(0.495) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF680 | SNV | Missense_Mutation | rs147253391 | c.178N>T | p.His60Tyr | p.H60Y | Q8NEM1 | protein_coding | deleterious(0.03) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF680 | SNV | Missense_Mutation | c.391G>A | p.Glu131Lys | p.E131K | Q8NEM1 | protein_coding | tolerated(0.05) | benign(0.108) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
ZNF680 | SNV | Missense_Mutation | c.1261N>T | p.Leu421Phe | p.L421F | Q8NEM1 | protein_coding | deleterious(0.04) | benign(0.193) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |