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Gene: ZNF576 |
Gene summary for ZNF576 |
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Gene information | Species | Human | Gene symbol | ZNF576 | Gene ID | 79177 |
Gene name | zinc finger protein 576 | |
Gene Alias | ZNF576 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0T0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79177 | ZNF576 | P56T-E | Human | Esophagus | ESCC | 1.58e-08 | 4.00e-01 | 0.1613 |
79177 | ZNF576 | P57T-E | Human | Esophagus | ESCC | 2.75e-05 | 1.85e-01 | 0.0926 |
79177 | ZNF576 | P61T-E | Human | Esophagus | ESCC | 4.38e-14 | 2.50e-01 | 0.099 |
79177 | ZNF576 | P62T-E | Human | Esophagus | ESCC | 3.40e-36 | 5.33e-01 | 0.1302 |
79177 | ZNF576 | P65T-E | Human | Esophagus | ESCC | 9.22e-15 | 3.24e-01 | 0.0978 |
79177 | ZNF576 | P74T-E | Human | Esophagus | ESCC | 8.20e-22 | 4.93e-01 | 0.1479 |
79177 | ZNF576 | P75T-E | Human | Esophagus | ESCC | 6.68e-29 | 4.81e-01 | 0.1125 |
79177 | ZNF576 | P76T-E | Human | Esophagus | ESCC | 6.62e-17 | 3.18e-01 | 0.1207 |
79177 | ZNF576 | P79T-E | Human | Esophagus | ESCC | 4.84e-28 | 4.40e-01 | 0.1154 |
79177 | ZNF576 | P80T-E | Human | Esophagus | ESCC | 1.28e-18 | 2.97e-01 | 0.155 |
79177 | ZNF576 | P82T-E | Human | Esophagus | ESCC | 9.03e-13 | 4.70e-01 | 0.1072 |
79177 | ZNF576 | P83T-E | Human | Esophagus | ESCC | 4.86e-26 | 6.72e-01 | 0.1738 |
79177 | ZNF576 | P84T-E | Human | Esophagus | ESCC | 3.62e-06 | 3.17e-01 | 0.0933 |
79177 | ZNF576 | P89T-E | Human | Esophagus | ESCC | 4.27e-12 | 4.87e-01 | 0.1752 |
79177 | ZNF576 | P91T-E | Human | Esophagus | ESCC | 7.76e-12 | 9.05e-01 | 0.1828 |
79177 | ZNF576 | P104T-E | Human | Esophagus | ESCC | 4.46e-05 | 2.48e-01 | 0.0931 |
79177 | ZNF576 | P107T-E | Human | Esophagus | ESCC | 4.57e-29 | 5.11e-01 | 0.171 |
79177 | ZNF576 | P127T-E | Human | Esophagus | ESCC | 6.40e-15 | 3.05e-01 | 0.0826 |
79177 | ZNF576 | P128T-E | Human | Esophagus | ESCC | 1.10e-25 | 5.95e-01 | 0.1241 |
79177 | ZNF576 | P130T-E | Human | Esophagus | ESCC | 6.04e-30 | 5.22e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF576 | SNV | Missense_Mutation | c.180C>G | p.Asp60Glu | p.D60E | Q9H609 | protein_coding | tolerated(0.64) | benign(0.234) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
ZNF576 | SNV | Missense_Mutation | novel | c.44N>T | p.Ser15Leu | p.S15L | Q9H609 | protein_coding | deleterious_low_confidence(0.05) | benign(0.001) | TCGA-C5-A907-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZNF576 | SNV | Missense_Mutation | c.202N>A | p.Gly68Arg | p.G68R | Q9H609 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | c.431N>T | p.Ala144Val | p.A144V | Q9H609 | protein_coding | tolerated(0.57) | benign(0.396) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF576 | SNV | Missense_Mutation | c.275N>A | p.Ser92Asn | p.S92N | Q9H609 | protein_coding | deleterious(0.03) | benign(0.247) | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD | |
ZNF576 | SNV | Missense_Mutation | c.271N>T | p.Arg91Cys | p.R91C | Q9H609 | protein_coding | deleterious(0.03) | benign(0.093) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | rs772352799 | c.229N>A | p.Ala77Thr | p.A77T | Q9H609 | protein_coding | tolerated(0.25) | possibly_damaging(0.598) | TCGA-A5-A0VO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF576 | SNV | Missense_Mutation | c.91N>A | p.Leu31Met | p.L31M | Q9H609 | protein_coding | tolerated(0.08) | possibly_damaging(0.467) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | c.230N>T | p.Ala77Val | p.A77V | Q9H609 | protein_coding | tolerated(0.07) | possibly_damaging(0.659) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF576 | SNV | Missense_Mutation | rs568418404 | c.152G>A | p.Arg51His | p.R51H | Q9H609 | protein_coding | tolerated(0.07) | probably_damaging(0.958) | TCGA-AP-A1DR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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