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Gene: ZNF37A |
Gene summary for ZNF37A |
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Gene information | Species | Human | Gene symbol | ZNF37A | Gene ID | 7587 |
Gene name | zinc finger protein 37A | |
Gene Alias | KOX21 | |
Cytomap | 10p11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17032 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7587 | ZNF37A | P75T-E | Human | Esophagus | ESCC | 6.66e-18 | 1.96e-01 | 0.1125 |
7587 | ZNF37A | P76T-E | Human | Esophagus | ESCC | 5.54e-14 | 1.77e-01 | 0.1207 |
7587 | ZNF37A | P79T-E | Human | Esophagus | ESCC | 2.21e-21 | 2.55e-01 | 0.1154 |
7587 | ZNF37A | P80T-E | Human | Esophagus | ESCC | 4.99e-29 | 9.11e-01 | 0.155 |
7587 | ZNF37A | P82T-E | Human | Esophagus | ESCC | 3.41e-08 | 3.31e-01 | 0.1072 |
7587 | ZNF37A | P83T-E | Human | Esophagus | ESCC | 4.50e-22 | 4.20e-01 | 0.1738 |
7587 | ZNF37A | P89T-E | Human | Esophagus | ESCC | 3.90e-02 | 1.84e-01 | 0.1752 |
7587 | ZNF37A | P91T-E | Human | Esophagus | ESCC | 1.60e-11 | 4.76e-01 | 0.1828 |
7587 | ZNF37A | P94T-E | Human | Esophagus | ESCC | 3.47e-02 | 2.57e-01 | 0.0879 |
7587 | ZNF37A | P104T-E | Human | Esophagus | ESCC | 7.66e-04 | 1.48e-01 | 0.0931 |
7587 | ZNF37A | P107T-E | Human | Esophagus | ESCC | 2.63e-09 | 1.49e-01 | 0.171 |
7587 | ZNF37A | P127T-E | Human | Esophagus | ESCC | 1.81e-10 | 1.51e-01 | 0.0826 |
7587 | ZNF37A | P128T-E | Human | Esophagus | ESCC | 1.54e-22 | 6.13e-01 | 0.1241 |
7587 | ZNF37A | P130T-E | Human | Esophagus | ESCC | 1.94e-33 | 6.27e-01 | 0.1676 |
7587 | ZNF37A | HCC1_Meng | Human | Liver | HCC | 3.16e-64 | 1.46e-01 | 0.0246 |
7587 | ZNF37A | HCC2_Meng | Human | Liver | HCC | 9.52e-17 | 9.78e-02 | 0.0107 |
7587 | ZNF37A | cirrhotic2 | Human | Liver | Cirrhotic | 5.18e-04 | 8.67e-02 | 0.0201 |
7587 | ZNF37A | HCC1 | Human | Liver | HCC | 2.81e-09 | 3.23e+00 | 0.5336 |
7587 | ZNF37A | HCC2 | Human | Liver | HCC | 2.30e-19 | 3.75e+00 | 0.5341 |
7587 | ZNF37A | HCC5 | Human | Liver | HCC | 4.62e-05 | 1.35e+00 | 0.4932 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF37A | SNV | Missense_Mutation | c.956N>T | p.Arg319Ile | p.R319I | P17032 | protein_coding | deleterious(0) | benign(0.142) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF37A | SNV | Missense_Mutation | rs752891741 | c.1042N>G | p.Thr348Ala | p.T348A | P17032 | protein_coding | tolerated(0.07) | benign(0.055) | TCGA-DS-A7WF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF37A | SNV | Missense_Mutation | rs371302765 | c.1430G>A | p.Arg477His | p.R477H | P17032 | protein_coding | tolerated(0.52) | benign(0.009) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF37A | SNV | Missense_Mutation | c.125N>A | p.Ser42Asn | p.S42N | P17032 | protein_coding | tolerated(0.22) | benign(0.298) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZNF37A | SNV | Missense_Mutation | novel | c.1259N>C | p.Phe420Ser | p.F420S | P17032 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
ZNF37A | SNV | Missense_Mutation | c.257N>T | p.Arg86Ile | p.R86I | P17032 | protein_coding | tolerated(0.2) | benign(0.041) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF37A | SNV | Missense_Mutation | c.805N>C | p.Lys269Gln | p.K269Q | P17032 | protein_coding | deleterious(0) | benign(0.045) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF37A | SNV | Missense_Mutation | c.1654N>C | p.Asn552His | p.N552H | P17032 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF37A | SNV | Missense_Mutation | rs747587314 | c.553N>T | p.Met185Leu | p.M185L | P17032 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF37A | SNV | Missense_Mutation | c.956G>T | p.Arg319Ile | p.R319I | P17032 | protein_coding | deleterious(0) | benign(0.142) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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