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Gene: ZNF362 |
Gene summary for ZNF362 |
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Gene information | Species | Human | Gene symbol | ZNF362 | Gene ID | 149076 |
Gene name | zinc finger protein 362 | |
Gene Alias | RN | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5T0B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
149076 | ZNF362 | P80T-E | Human | Esophagus | ESCC | 1.02e-02 | 1.81e-01 | 0.155 |
149076 | ZNF362 | P91T-E | Human | Esophagus | ESCC | 8.21e-06 | 7.70e-01 | 0.1828 |
149076 | ZNF362 | P104T-E | Human | Esophagus | ESCC | 2.56e-02 | 1.49e-01 | 0.0931 |
149076 | ZNF362 | P107T-E | Human | Esophagus | ESCC | 1.12e-07 | 1.02e-01 | 0.171 |
149076 | ZNF362 | P127T-E | Human | Esophagus | ESCC | 7.51e-10 | 1.69e-01 | 0.0826 |
149076 | ZNF362 | P128T-E | Human | Esophagus | ESCC | 7.79e-05 | 1.88e-01 | 0.1241 |
149076 | ZNF362 | P130T-E | Human | Esophagus | ESCC | 8.62e-26 | 5.18e-01 | 0.1676 |
149076 | ZNF362 | male-WTA | Human | Thyroid | PTC | 1.65e-15 | 1.91e-01 | 0.1037 |
149076 | ZNF362 | PTC01 | Human | Thyroid | PTC | 5.80e-05 | 2.91e-02 | 0.1899 |
149076 | ZNF362 | PTC04 | Human | Thyroid | PTC | 1.57e-05 | 4.55e-02 | 0.1927 |
149076 | ZNF362 | PTC05 | Human | Thyroid | PTC | 1.18e-05 | 2.43e-01 | 0.2065 |
149076 | ZNF362 | PTC06 | Human | Thyroid | PTC | 1.64e-14 | 2.91e-01 | 0.2057 |
149076 | ZNF362 | PTC07 | Human | Thyroid | PTC | 4.51e-20 | 1.37e-01 | 0.2044 |
149076 | ZNF362 | ATC12 | Human | Thyroid | ATC | 2.20e-10 | 7.98e-02 | 0.34 |
149076 | ZNF362 | ATC13 | Human | Thyroid | ATC | 5.53e-30 | 5.37e-01 | 0.34 |
149076 | ZNF362 | ATC2 | Human | Thyroid | ATC | 5.04e-03 | 2.61e-01 | 0.34 |
149076 | ZNF362 | ATC4 | Human | Thyroid | ATC | 1.87e-07 | 9.72e-02 | 0.34 |
149076 | ZNF362 | ATC5 | Human | Thyroid | ATC | 1.55e-29 | 5.88e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF362 | SNV | Missense_Mutation | rs767611931 | c.614N>T | p.Pro205Leu | p.P205L | Q5T0B9 | protein_coding | tolerated(0.42) | benign(0.212) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF362 | SNV | Missense_Mutation | c.962N>T | p.Ala321Val | p.A321V | Q5T0B9 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF362 | SNV | Missense_Mutation | novel | c.883N>T | p.Leu295Phe | p.L295F | Q5T0B9 | protein_coding | deleterious(0) | benign(0.22) | TCGA-VS-A8Q9-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF362 | SNV | Missense_Mutation | novel | c.478N>C | p.Ser160Pro | p.S160P | Q5T0B9 | protein_coding | tolerated(0.16) | benign(0.26) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF362 | SNV | Missense_Mutation | c.536T>A | p.Ile179Asn | p.I179N | Q5T0B9 | protein_coding | tolerated(0.58) | benign(0.011) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF362 | SNV | Missense_Mutation | c.1213C>T | p.Pro405Ser | p.P405S | Q5T0B9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF362 | SNV | Missense_Mutation | rs377378847 | c.1060G>A | p.Ala354Thr | p.A354T | Q5T0B9 | protein_coding | tolerated(0.13) | benign(0.102) | TCGA-DM-A28K-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF362 | SNV | Missense_Mutation | c.696C>G | p.Cys232Trp | p.C232W | Q5T0B9 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF362 | deletion | Frame_Shift_Del | c.611delG | p.Gly204ValfsTer6 | p.G204Vfs*6 | Q5T0B9 | protein_coding | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |||
ZNF362 | SNV | Missense_Mutation | rs756484246 | c.547G>A | p.Gly183Ser | p.G183S | Q5T0B9 | protein_coding | tolerated(0.28) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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