![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF302 |
Gene summary for ZNF302 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF302 | Gene ID | 55900 |
Gene name | zinc finger protein 302 | |
Gene Alias | HSD16 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NR11 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55900 | ZNF302 | P57T-E | Human | Esophagus | ESCC | 1.71e-16 | 3.66e-01 | 0.0926 |
55900 | ZNF302 | P61T-E | Human | Esophagus | ESCC | 1.73e-28 | 6.22e-01 | 0.099 |
55900 | ZNF302 | P62T-E | Human | Esophagus | ESCC | 3.78e-25 | 4.19e-01 | 0.1302 |
55900 | ZNF302 | P65T-E | Human | Esophagus | ESCC | 9.98e-19 | 3.49e-01 | 0.0978 |
55900 | ZNF302 | P74T-E | Human | Esophagus | ESCC | 1.56e-21 | 5.84e-01 | 0.1479 |
55900 | ZNF302 | P75T-E | Human | Esophagus | ESCC | 4.92e-19 | 4.23e-01 | 0.1125 |
55900 | ZNF302 | P76T-E | Human | Esophagus | ESCC | 3.93e-12 | 2.89e-01 | 0.1207 |
55900 | ZNF302 | P79T-E | Human | Esophagus | ESCC | 3.57e-27 | 4.92e-01 | 0.1154 |
55900 | ZNF302 | P80T-E | Human | Esophagus | ESCC | 4.27e-13 | 3.73e-01 | 0.155 |
55900 | ZNF302 | P82T-E | Human | Esophagus | ESCC | 1.75e-10 | 5.47e-01 | 0.1072 |
55900 | ZNF302 | P83T-E | Human | Esophagus | ESCC | 2.78e-17 | 3.81e-01 | 0.1738 |
55900 | ZNF302 | P84T-E | Human | Esophagus | ESCC | 3.90e-04 | 2.23e-01 | 0.0933 |
55900 | ZNF302 | P89T-E | Human | Esophagus | ESCC | 6.38e-10 | 5.20e-01 | 0.1752 |
55900 | ZNF302 | P91T-E | Human | Esophagus | ESCC | 4.87e-02 | 5.40e-01 | 0.1828 |
55900 | ZNF302 | P107T-E | Human | Esophagus | ESCC | 3.16e-14 | 3.90e-01 | 0.171 |
55900 | ZNF302 | P127T-E | Human | Esophagus | ESCC | 2.58e-19 | 3.28e-01 | 0.0826 |
55900 | ZNF302 | P128T-E | Human | Esophagus | ESCC | 3.25e-19 | 5.57e-01 | 0.1241 |
55900 | ZNF302 | P130T-E | Human | Esophagus | ESCC | 3.80e-19 | 4.44e-01 | 0.1676 |
55900 | ZNF302 | S43 | Human | Liver | Cirrhotic | 8.40e-10 | -2.22e-01 | -0.0187 |
55900 | ZNF302 | HCC1_Meng | Human | Liver | HCC | 3.31e-48 | -1.62e-01 | 0.0246 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF302 | CYC | Skin | Healthy | SEPT4,LARP6,NRXN1, etc. | 3.07e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF302 | SNV | Missense_Mutation | c.732N>G | p.Ile244Met | p.I244M | protein_coding | tolerated(0.05) | benign(0.293) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
ZNF302 | SNV | Missense_Mutation | rs767107732 | c.1079N>A | p.Arg360His | p.R360H | protein_coding | tolerated(0.05) | possibly_damaging(0.809) | TCGA-BH-A0BC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ZNF302 | SNV | Missense_Mutation | novel | c.1039N>T | p.His347Tyr | p.H347Y | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF302 | SNV | Missense_Mutation | c.1319N>G | p.Pro440Arg | p.P440R | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF302 | SNV | Missense_Mutation | novel | c.78N>C | p.Met26Ile | p.M26I | protein_coding | tolerated_low_confidence(0.46) | benign(0) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF302 | SNV | Missense_Mutation | novel | c.1214G>A | p.Arg405Lys | p.R405K | protein_coding | tolerated(0.05) | benign(0.006) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF302 | SNV | Missense_Mutation | c.439N>C | p.Val147Leu | p.V147L | protein_coding | tolerated(0.46) | benign(0.006) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | ||
ZNF302 | SNV | Missense_Mutation | c.1265T>A | p.Phe422Tyr | p.F422Y | protein_coding | deleterious(0.05) | probably_damaging(0.92) | TCGA-AA-3506-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF302 | SNV | Missense_Mutation | rs766941441 | c.826C>T | p.Arg276Cys | p.R276C | protein_coding | deleterious(0.02) | possibly_damaging(0.828) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF302 | SNV | Missense_Mutation | c.151N>C | p.Ser51Arg | p.S51R | protein_coding | tolerated(1) | benign(0.165) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |