Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF16

Gene summary for ZNF16

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF16

Gene ID

7564

Gene namezinc finger protein 16
Gene AliasHZF1
Cytomap8q24.3
Gene Typeprotein-coding
GO ID

GO:0002262

UniProtAcc

P17020


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7564ZNF16P84T-EHumanEsophagusESCC1.06e-031.90e-010.0933
7564ZNF16P89T-EHumanEsophagusESCC5.33e-064.28e-010.1752
7564ZNF16P91T-EHumanEsophagusESCC8.74e-053.53e-010.1828
7564ZNF16P107T-EHumanEsophagusESCC2.29e-163.28e-010.171
7564ZNF16P128T-EHumanEsophagusESCC1.14e-308.05e-010.1241
7564ZNF16P130T-EHumanEsophagusESCC1.88e-112.25e-010.1676
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190198713EsophagusESCCregulation of cell cycle phase transition242/8552390/187233.86e-111.26e-09242
GO:004578710EsophagusESCCpositive regulation of cell cycle196/8552313/187239.27e-102.24e-08196
GO:0030099111EsophagusESCCmyeloid cell differentiation232/8552381/187231.22e-092.90e-08232
GO:0002262111EsophagusESCCmyeloid cell homeostasis104/8552157/187231.49e-072.36e-06104
GO:0034101111EsophagusESCCerythrocyte homeostasis88/8552129/187231.81e-072.84e-0688
GO:0048872111EsophagusESCChomeostasis of number of cells163/8552272/187231.40e-061.69e-05163
GO:0030218111EsophagusESCCerythrocyte differentiation80/8552120/187232.69e-063.08e-0580
GO:19019896EsophagusESCCpositive regulation of cell cycle phase transition77/8552115/187233.20e-063.58e-0577
GO:00900689EsophagusESCCpositive regulation of cell cycle process142/8552236/187234.79e-065.08e-05142
GO:003367420EsophagusESCCpositive regulation of kinase activity260/8552467/187237.26e-067.22e-05260
GO:1903706110EsophagusESCCregulation of hemopoiesis201/8552367/187232.60e-041.58e-03201
GO:004563918EsophagusESCCpositive regulation of myeloid cell differentiation64/8552103/187235.54e-043.03e-0364
GO:0045637111EsophagusESCCregulation of myeloid cell differentiation118/8552210/187231.35e-036.43e-03118
GO:004564619EsophagusESCCregulation of erythrocyte differentiation32/855247/187231.59e-037.43e-0332
GO:00513025EsophagusESCCregulation of cell division97/8552177/187238.93e-033.12e-0297
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF16MYOEPIBreastIDCTMEM47,SYT13,LRP5L, etc.4.27e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16M2MACBreastHealthyCLIC2,ITGA5,RCCD1, etc.3.04e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16M2MACBreastIDCCLIC2,ITGA5,RCCD1, etc.2.01e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16CTColorectumHealthyMTRNR2L8,ARL16,OPN3, etc.1.41e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16CFIBColorectumFAPGARNL3,ZNF518A,CCDC59, etc.2.80e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16CD8TEXPEndometriumHealthyARHGAP45,TCF7,DCAF17, etc.1.50e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16FIBOral cavityHealthyMIGA1,GOLGA8A,ATP13A2, etc.1.58e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16CAFOral cavityNEOLPMIGA1,GOLGA8A,ATP13A2, etc.8.70e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16PTCThyroidADJCLMN,MIAT,XRCC3, etc.9.40e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF16TFCThyroidgoitersCLMN,MIAT,XRCC3, etc.9.02e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF16SNVMissense_Mutationc.550G>Ap.Asp184Asnp.D184NP17020protein_codingtolerated(1)benign(0.006)TCGA-A2-A25E-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanPD
ZNF16SNVMissense_Mutationnovelc.526N>Gp.Thr176Alap.T176AP17020protein_codingtolerated(0.11)benign(0)TCGA-AC-A3W7-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
ZNF16SNVMissense_Mutationnovelc.17N>Tp.Thr6Ilep.T6IP17020protein_codingtolerated_low_confidence(0.06)benign(0)TCGA-BH-A0H9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ZNF16SNVMissense_Mutationrs753210600c.1451C>Tp.Thr484Metp.T484MP17020protein_codingdeleterious(0)probably_damaging(0.999)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF16SNVMissense_Mutationrs769737434c.23N>Ap.Arg8Hisp.R8HP17020protein_codingtolerated_low_confidence(0.06)benign(0)TCGA-D8-A27G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF16insertionNonsense_Mutationnovelc.1853_1854insTGAGCTATTGTGCCTGGCCAGAAAGTGAGTGTTGGTGACATGCp.Gln618HisfsTer10p.Q618Hfs*10P17020protein_codingTCGA-A8-A06X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF16insertionNonsense_Mutationnovelc.1910_1911insACTTCCTTGAATTTCTGCACCAACTATTTTATTTGGATCCp.Phe638LeufsTer3p.F638Lfs*3P17020protein_codingTCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF16insertionNonsense_Mutationnovelc.421_422insCATCCATATGACATGGGTGGCCAGAGTTTCAp.Met141ThrfsTer4p.M141Tfs*4P17020protein_codingTCGA-B6-A0IJ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF16insertionFrame_Shift_Insnovelc.1868_1869insAGACATCAp.His623GlnfsTer35p.H623Qfs*35P17020protein_codingTCGA-BH-A0BA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
ZNF16insertionNonsense_Mutationnovelc.1803_1804insCCCCATCCTTAGTTCTCAGAGCTGTGCTCCTGTp.Tyr601_Thr602insProHisProTerPheSerGluLeuCysSerCysp.Y601_T602insPHP*FSELCSCP17020protein_codingTCGA-BH-A0HK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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