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Gene: ZNF121 |
Gene summary for ZNF121 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF121 | Gene ID | 7675 |
| Gene name | zinc finger protein 121 | |
| Gene Alias | D19S204 | |
| Cytomap | 19p13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P58317 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7675 | ZNF121 | P56T-E | Human | Esophagus | ESCC | 4.79e-02 | 1.87e-01 | 0.1613 |
| 7675 | ZNF121 | P57T-E | Human | Esophagus | ESCC | 2.99e-08 | -4.42e-04 | 0.0926 |
| 7675 | ZNF121 | P61T-E | Human | Esophagus | ESCC | 5.31e-09 | 8.74e-02 | 0.099 |
| 7675 | ZNF121 | P62T-E | Human | Esophagus | ESCC | 2.03e-22 | 4.39e-01 | 0.1302 |
| 7675 | ZNF121 | P65T-E | Human | Esophagus | ESCC | 1.51e-06 | 4.34e-02 | 0.0978 |
| 7675 | ZNF121 | P74T-E | Human | Esophagus | ESCC | 2.66e-04 | -6.26e-03 | 0.1479 |
| 7675 | ZNF121 | P75T-E | Human | Esophagus | ESCC | 2.61e-17 | 2.96e-01 | 0.1125 |
| 7675 | ZNF121 | P76T-E | Human | Esophagus | ESCC | 5.83e-18 | 4.31e-02 | 0.1207 |
| 7675 | ZNF121 | P79T-E | Human | Esophagus | ESCC | 9.12e-16 | 1.60e-01 | 0.1154 |
| 7675 | ZNF121 | P80T-E | Human | Esophagus | ESCC | 5.02e-17 | 3.45e-01 | 0.155 |
| 7675 | ZNF121 | P82T-E | Human | Esophagus | ESCC | 2.62e-02 | 1.36e-01 | 0.1072 |
| 7675 | ZNF121 | P83T-E | Human | Esophagus | ESCC | 1.04e-15 | 2.04e-01 | 0.1738 |
| 7675 | ZNF121 | P89T-E | Human | Esophagus | ESCC | 1.29e-13 | 4.39e-01 | 0.1752 |
| 7675 | ZNF121 | P91T-E | Human | Esophagus | ESCC | 6.18e-05 | 3.32e-01 | 0.1828 |
| 7675 | ZNF121 | P107T-E | Human | Esophagus | ESCC | 9.57e-18 | 3.85e-01 | 0.171 |
| 7675 | ZNF121 | P126T-E | Human | Esophagus | ESCC | 2.13e-02 | 5.13e-01 | 0.1125 |
| 7675 | ZNF121 | P127T-E | Human | Esophagus | ESCC | 2.92e-13 | 1.90e-01 | 0.0826 |
| 7675 | ZNF121 | P128T-E | Human | Esophagus | ESCC | 6.33e-19 | 7.05e-01 | 0.1241 |
| 7675 | ZNF121 | P130T-E | Human | Esophagus | ESCC | 6.50e-22 | 3.21e-01 | 0.1676 |
| 7675 | ZNF121 | HCC1_Meng | Human | Liver | HCC | 5.95e-39 | 1.96e-02 | 0.0246 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF121 | TH1 | Colorectum | AD | GIMAP4,FOS,TRAPPC4, etc. | 1.54e-02 |  |
| ZNF121 | TH1 | Colorectum | MSI-H | GIMAP4,FOS,TRAPPC4, etc. | 2.01e-02 |  |
| ZNF121 | GC | Colorectum | SER | GIMAP4,FOS,TRAPPC4, etc. | 2.65e-02 |  |
| ZNF121 | CD8TEFF | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 |  |
| ZNF121 | NEUT | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -2.22e-16 | |
| ZNF121 | TH1 | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -4.44e-16 | |
| ZNF121 | CD4TN | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 | |
| ZNF121 | CD8TEREX | Endometrium | ADJ | LUZP1,STK38L,TMEM164, etc. | -4.44e-16 | |
| ZNF121 | CD4TN | Endometrium | AEH | LUZP1,STK38L,TMEM164, etc. | 0.00e+00 |  |
| ZNF121 | MAST | Endometrium | AEH | LUZP1,STK38L,TMEM164, etc. | 1.36e-02 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF121 | SNV | Missense_Mutation | rs751459507 | c.232N>T | p.His78Tyr | p.H78Y | P58317 | protein_coding | tolerated(1) | benign(0.003) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
| ZNF121 | SNV | Missense_Mutation | novel | c.956A>T | p.Lys319Ile | p.K319I | P58317 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A576-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
| ZNF121 | SNV | Missense_Mutation | c.461N>A | p.Arg154Lys | p.R154K | P58317 | protein_coding | tolerated(0.32) | benign(0.145) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
| ZNF121 | SNV | Missense_Mutation | c.1014N>C | p.Lys338Asn | p.K338N | P58317 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZNF121 | SNV | Missense_Mutation | novel | c.651A>T | p.Lys217Asn | p.K217N | P58317 | protein_coding | tolerated(0.21) | possibly_damaging(0.855) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF121 | SNV | Missense_Mutation | rs866277666 | c.659G>A | p.Arg220Gln | p.R220Q | P58317 | protein_coding | tolerated(0.29) | possibly_damaging(0.872) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF121 | SNV | Missense_Mutation | novel | c.425A>C | p.Lys142Thr | p.K142T | P58317 | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF121 | SNV | Missense_Mutation | c.1079G>T | p.Arg360Ile | p.R360I | P58317 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| ZNF121 | SNV | Missense_Mutation | c.835N>G | p.Thr279Ala | p.T279A | P58317 | protein_coding | deleterious(0.04) | benign(0.179) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ZNF121 | SNV | Missense_Mutation | c.761A>C | p.Lys254Thr | p.K254T | P58317 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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