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Gene: ZDHHC9 |
Gene summary for ZDHHC9 |
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Gene information | Species | Human | Gene symbol | ZDHHC9 | Gene ID | 51114 |
Gene name | zinc finger DHHC-type palmitoyltransferase 9 | |
Gene Alias | CGI89 | |
Cytomap | Xq26.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9Y397 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51114 | ZDHHC9 | P27T-E | Human | Esophagus | ESCC | 8.06e-13 | 1.92e-01 | 0.1055 |
51114 | ZDHHC9 | P28T-E | Human | Esophagus | ESCC | 5.77e-14 | 1.71e-01 | 0.1149 |
51114 | ZDHHC9 | P30T-E | Human | Esophagus | ESCC | 9.50e-20 | 5.32e-01 | 0.137 |
51114 | ZDHHC9 | P31T-E | Human | Esophagus | ESCC | 6.27e-21 | 3.23e-01 | 0.1251 |
51114 | ZDHHC9 | P32T-E | Human | Esophagus | ESCC | 4.13e-22 | 4.00e-01 | 0.1666 |
51114 | ZDHHC9 | P36T-E | Human | Esophagus | ESCC | 6.20e-11 | 3.67e-01 | 0.1187 |
51114 | ZDHHC9 | P37T-E | Human | Esophagus | ESCC | 2.90e-21 | 3.93e-01 | 0.1371 |
51114 | ZDHHC9 | P38T-E | Human | Esophagus | ESCC | 2.19e-10 | 2.70e-01 | 0.127 |
51114 | ZDHHC9 | P39T-E | Human | Esophagus | ESCC | 2.04e-14 | 2.46e-01 | 0.0894 |
51114 | ZDHHC9 | P40T-E | Human | Esophagus | ESCC | 2.42e-11 | 2.64e-01 | 0.109 |
51114 | ZDHHC9 | P42T-E | Human | Esophagus | ESCC | 1.11e-10 | 2.90e-01 | 0.1175 |
51114 | ZDHHC9 | P44T-E | Human | Esophagus | ESCC | 5.14e-08 | 1.92e-01 | 0.1096 |
51114 | ZDHHC9 | P47T-E | Human | Esophagus | ESCC | 3.60e-19 | 2.87e-01 | 0.1067 |
51114 | ZDHHC9 | P48T-E | Human | Esophagus | ESCC | 1.04e-15 | 1.10e-01 | 0.0959 |
51114 | ZDHHC9 | P49T-E | Human | Esophagus | ESCC | 1.51e-15 | 1.68e+00 | 0.1768 |
51114 | ZDHHC9 | P52T-E | Human | Esophagus | ESCC | 2.08e-17 | 3.82e-01 | 0.1555 |
51114 | ZDHHC9 | P54T-E | Human | Esophagus | ESCC | 4.41e-21 | 1.60e-01 | 0.0975 |
51114 | ZDHHC9 | P56T-E | Human | Esophagus | ESCC | 4.77e-02 | 5.13e-01 | 0.1613 |
51114 | ZDHHC9 | P57T-E | Human | Esophagus | ESCC | 2.81e-17 | 2.25e-01 | 0.0926 |
51114 | ZDHHC9 | P61T-E | Human | Esophagus | ESCC | 2.98e-08 | 9.48e-02 | 0.099 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
GO:00066053 | Colorectum | MSI-H | protein targeting | 44/1319 | 314/18723 | 9.50e-06 | 4.55e-04 | 44 |
GO:00901503 | Colorectum | MSI-H | establishment of protein localization to membrane | 32/1319 | 260/18723 | 1.47e-03 | 2.23e-02 | 32 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:0006612 | Colorectum | FAP | protein targeting to membrane | 30/2622 | 131/18723 | 3.95e-03 | 2.75e-02 | 30 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:00421573 | Esophagus | ESCC | lipoprotein metabolic process | 86/8552 | 135/18723 | 1.78e-05 | 1.57e-04 | 86 |
GO:00064973 | Esophagus | ESCC | protein lipidation | 62/8552 | 92/18723 | 2.08e-05 | 1.80e-04 | 62 |
GO:00421583 | Esophagus | ESCC | lipoprotein biosynthetic process | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00066124 | Esophagus | ESCC | protein targeting to membrane | 83/8552 | 131/18723 | 3.31e-05 | 2.73e-04 | 83 |
GO:0043543 | Liver | NAFLD | protein acylation | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDHHC9 | SNV | Missense_Mutation | c.496N>A | p.Asp166Asn | p.D166N | Q9Y397 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A24V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZDHHC9 | SNV | Missense_Mutation | novel | c.83G>A | p.Arg28His | p.R28H | Q9Y397 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD |
ZDHHC9 | SNV | Missense_Mutation | c.252G>T | p.Leu84Phe | p.L84F | Q9Y397 | protein_coding | tolerated(0.18) | possibly_damaging(0.593) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
ZDHHC9 | insertion | Frame_Shift_Ins | novel | c.168-1_168insATCACTT | p.Cys57SerfsTer36 | p.C57Sfs*36 | Q9Y397 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ZDHHC9 | SNV | Missense_Mutation | rs767597857 | c.98G>A | p.Arg33Gln | p.R33Q | Q9Y397 | protein_coding | tolerated(0.1) | possibly_damaging(0.801) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZDHHC9 | SNV | Missense_Mutation | c.667N>T | p.Pro223Ser | p.P223S | Q9Y397 | protein_coding | deleterious(0.02) | possibly_damaging(0.905) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZDHHC9 | SNV | Missense_Mutation | c.435N>T | p.Lys145Asn | p.K145N | Q9Y397 | protein_coding | deleterious(0) | possibly_damaging(0.823) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZDHHC9 | SNV | Missense_Mutation | c.881N>T | p.Ser294Ile | p.S294I | Q9Y397 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZDHHC9 | SNV | Missense_Mutation | novel | c.362G>A | p.Arg121Gln | p.R121Q | Q9Y397 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZDHHC9 | SNV | Missense_Mutation | c.1006G>A | p.Glu336Lys | p.E336K | Q9Y397 | protein_coding | tolerated(0.53) | benign(0.017) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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