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Gene: ZC2HC1A |
Gene summary for ZC2HC1A |
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Gene information | Species | Human | Gene symbol | ZC2HC1A | Gene ID | 51101 |
Gene name | zinc finger C2HC-type containing 1A | |
Gene Alias | C8orf70 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B2R9B8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51101 | ZC2HC1A | P62T-E | Human | Esophagus | ESCC | 2.00e-30 | 6.74e-01 | 0.1302 |
51101 | ZC2HC1A | P65T-E | Human | Esophagus | ESCC | 2.60e-43 | 9.23e-01 | 0.0978 |
51101 | ZC2HC1A | P74T-E | Human | Esophagus | ESCC | 7.02e-14 | 4.99e-01 | 0.1479 |
51101 | ZC2HC1A | P75T-E | Human | Esophagus | ESCC | 3.99e-26 | 5.09e-01 | 0.1125 |
51101 | ZC2HC1A | P76T-E | Human | Esophagus | ESCC | 9.13e-15 | 3.00e-01 | 0.1207 |
51101 | ZC2HC1A | P79T-E | Human | Esophagus | ESCC | 1.77e-28 | 6.67e-01 | 0.1154 |
51101 | ZC2HC1A | P80T-E | Human | Esophagus | ESCC | 1.33e-11 | 3.47e-01 | 0.155 |
51101 | ZC2HC1A | P82T-E | Human | Esophagus | ESCC | 6.63e-05 | 6.07e-01 | 0.1072 |
51101 | ZC2HC1A | P83T-E | Human | Esophagus | ESCC | 3.32e-10 | 2.70e-01 | 0.1738 |
51101 | ZC2HC1A | P84T-E | Human | Esophagus | ESCC | 2.06e-14 | 8.74e-01 | 0.0933 |
51101 | ZC2HC1A | P89T-E | Human | Esophagus | ESCC | 2.52e-12 | 7.53e-01 | 0.1752 |
51101 | ZC2HC1A | P91T-E | Human | Esophagus | ESCC | 1.06e-02 | 2.09e-01 | 0.1828 |
51101 | ZC2HC1A | P107T-E | Human | Esophagus | ESCC | 1.09e-09 | 2.45e-01 | 0.171 |
51101 | ZC2HC1A | P127T-E | Human | Esophagus | ESCC | 2.39e-06 | 8.89e-02 | 0.0826 |
51101 | ZC2HC1A | P128T-E | Human | Esophagus | ESCC | 4.98e-15 | 4.34e-01 | 0.1241 |
51101 | ZC2HC1A | P130T-E | Human | Esophagus | ESCC | 2.71e-07 | 8.39e-02 | 0.1676 |
51101 | ZC2HC1A | C21 | Human | Oral cavity | OSCC | 1.64e-11 | 4.05e-01 | 0.2678 |
51101 | ZC2HC1A | C30 | Human | Oral cavity | OSCC | 5.31e-06 | 3.61e-01 | 0.3055 |
51101 | ZC2HC1A | C38 | Human | Oral cavity | OSCC | 1.98e-05 | 8.20e-01 | 0.172 |
51101 | ZC2HC1A | C43 | Human | Oral cavity | OSCC | 2.80e-13 | 2.98e-01 | 0.1704 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC2HC1A | SNV | Missense_Mutation | novel | c.317N>C | p.Lys106Thr | p.K106T | Q96GY0 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZC2HC1A | SNV | Missense_Mutation | novel | c.520C>A | p.Leu174Ile | p.L174I | Q96GY0 | protein_coding | tolerated(0.49) | benign(0.01) | TCGA-B6-A40C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | cyclophosphamide | SD |
ZC2HC1A | SNV | Missense_Mutation | c.833N>G | p.Ser278Cys | p.S278C | Q96GY0 | protein_coding | tolerated(0.07) | possibly_damaging(0.817) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZC2HC1A | SNV | Missense_Mutation | rs143922654 | c.136C>T | p.Arg46Trp | p.R46W | Q96GY0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A576-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
ZC2HC1A | SNV | Missense_Mutation | c.256G>A | p.Glu86Lys | p.E86K | Q96GY0 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-C5-A1BN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZC2HC1A | deletion | Frame_Shift_Del | novel | c.130delN | p.Lys45AsnfsTer20 | p.K45Nfs*20 | Q96GY0 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ZC2HC1A | insertion | Frame_Shift_Ins | novel | c.662_663insA | p.Ser223IlefsTer5 | p.S223Ifs*5 | Q96GY0 | protein_coding | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
ZC2HC1A | SNV | Missense_Mutation | novel | c.297N>T | p.Gln99His | p.Q99H | Q96GY0 | protein_coding | tolerated(0.11) | benign(0.03) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZC2HC1A | SNV | Missense_Mutation | novel | c.60G>T | p.Lys20Asn | p.K20N | Q96GY0 | protein_coding | tolerated(0.69) | benign(0.057) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZC2HC1A | SNV | Missense_Mutation | novel | c.950N>G | p.Glu317Gly | p.E317G | Q96GY0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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