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Gene: WBP4 |
Gene summary for WBP4 |
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Gene information | Species | Human | Gene symbol | WBP4 | Gene ID | 11193 |
Gene name | WW domain binding protein 4 | |
Gene Alias | FBP21 | |
Cytomap | 13q14.11 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O75554 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11193 | WBP4 | P56T-E | Human | Esophagus | ESCC | 1.06e-09 | 1.08e+00 | 0.1613 |
11193 | WBP4 | P57T-E | Human | Esophagus | ESCC | 9.09e-13 | 1.91e-01 | 0.0926 |
11193 | WBP4 | P61T-E | Human | Esophagus | ESCC | 8.14e-12 | 2.98e-01 | 0.099 |
11193 | WBP4 | P62T-E | Human | Esophagus | ESCC | 4.28e-36 | 6.89e-01 | 0.1302 |
11193 | WBP4 | P65T-E | Human | Esophagus | ESCC | 1.73e-21 | 5.25e-01 | 0.0978 |
11193 | WBP4 | P74T-E | Human | Esophagus | ESCC | 5.60e-19 | 6.18e-01 | 0.1479 |
11193 | WBP4 | P75T-E | Human | Esophagus | ESCC | 1.78e-10 | 1.76e-01 | 0.1125 |
11193 | WBP4 | P76T-E | Human | Esophagus | ESCC | 2.81e-22 | 3.02e-01 | 0.1207 |
11193 | WBP4 | P79T-E | Human | Esophagus | ESCC | 1.10e-28 | 5.28e-01 | 0.1154 |
11193 | WBP4 | P80T-E | Human | Esophagus | ESCC | 3.44e-20 | 6.18e-01 | 0.155 |
11193 | WBP4 | P82T-E | Human | Esophagus | ESCC | 1.19e-09 | 4.31e-01 | 0.1072 |
11193 | WBP4 | P83T-E | Human | Esophagus | ESCC | 1.25e-18 | 4.79e-01 | 0.1738 |
11193 | WBP4 | P84T-E | Human | Esophagus | ESCC | 5.97e-09 | 5.38e-01 | 0.0933 |
11193 | WBP4 | P89T-E | Human | Esophagus | ESCC | 7.87e-07 | 5.08e-01 | 0.1752 |
11193 | WBP4 | P91T-E | Human | Esophagus | ESCC | 1.59e-13 | 1.45e+00 | 0.1828 |
11193 | WBP4 | P104T-E | Human | Esophagus | ESCC | 3.51e-05 | 4.46e-01 | 0.0931 |
11193 | WBP4 | P107T-E | Human | Esophagus | ESCC | 1.27e-18 | 5.08e-01 | 0.171 |
11193 | WBP4 | P126T-E | Human | Esophagus | ESCC | 2.16e-06 | 6.35e-01 | 0.1125 |
11193 | WBP4 | P127T-E | Human | Esophagus | ESCC | 5.90e-07 | 6.50e-02 | 0.0826 |
11193 | WBP4 | P128T-E | Human | Esophagus | ESCC | 2.45e-19 | 4.85e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WBP4 | SNV | Missense_Mutation | novel | c.1031N>A | p.Ser344Tyr | p.S344Y | O75554 | protein_coding | deleterious(0) | possibly_damaging(0.651) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WBP4 | SNV | Missense_Mutation | c.234N>T | p.Glu78Asp | p.E78D | O75554 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C8-A12M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WBP4 | SNV | Missense_Mutation | novel | c.928N>T | p.Val310Leu | p.V310L | O75554 | protein_coding | deleterious(0) | benign(0.053) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
WBP4 | SNV | Missense_Mutation | novel | c.576G>T | p.Glu192Asp | p.E192D | O75554 | protein_coding | deleterious(0.02) | probably_damaging(0.96) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WBP4 | SNV | Missense_Mutation | c.1052G>T | p.Gly351Val | p.G351V | O75554 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WBP4 | SNV | Missense_Mutation | c.1046C>T | p.Ala349Val | p.A349V | O75554 | protein_coding | deleterious(0.02) | benign(0.158) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
WBP4 | SNV | Missense_Mutation | c.788N>C | p.Asp263Ala | p.D263A | O75554 | protein_coding | tolerated(0.6) | benign(0) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WBP4 | SNV | Missense_Mutation | novel | c.365N>C | p.Asp122Ala | p.D122A | O75554 | protein_coding | tolerated(0.4) | benign(0.162) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WBP4 | SNV | Missense_Mutation | rs760308349 | c.854C>T | p.Ser285Leu | p.S285L | O75554 | protein_coding | tolerated(0.13) | benign(0.143) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WBP4 | SNV | Missense_Mutation | c.199N>T | p.Ala67Ser | p.A67S | O75554 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AZ-4308-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Targeted Molecular therapy | avastin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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