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Gene: WARS2 |
Gene summary for WARS2 |
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Gene information | Species | Human | Gene symbol | WARS2 | Gene ID | 10352 |
Gene name | tryptophanyl tRNA synthetase 2, mitochondrial | |
Gene Alias | NEMMLAS | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | Q9UGM6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10352 | WARS2 | P79T-E | Human | Esophagus | ESCC | 8.41e-17 | 2.52e-01 | 0.1154 |
10352 | WARS2 | P80T-E | Human | Esophagus | ESCC | 1.46e-20 | 4.10e-01 | 0.155 |
10352 | WARS2 | P83T-E | Human | Esophagus | ESCC | 6.90e-14 | 4.21e-01 | 0.1738 |
10352 | WARS2 | P89T-E | Human | Esophagus | ESCC | 3.24e-08 | 3.84e-01 | 0.1752 |
10352 | WARS2 | P91T-E | Human | Esophagus | ESCC | 9.57e-07 | 5.98e-01 | 0.1828 |
10352 | WARS2 | P107T-E | Human | Esophagus | ESCC | 5.10e-37 | 8.88e-01 | 0.171 |
10352 | WARS2 | P127T-E | Human | Esophagus | ESCC | 7.38e-19 | 2.27e-01 | 0.0826 |
10352 | WARS2 | P128T-E | Human | Esophagus | ESCC | 2.06e-21 | 6.62e-01 | 0.1241 |
10352 | WARS2 | P130T-E | Human | Esophagus | ESCC | 2.31e-28 | 4.87e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WARS2 | SNV | Missense_Mutation | c.877C>A | p.Arg293Ser | p.R293S | Q9UGM6 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
WARS2 | SNV | Missense_Mutation | c.14C>T | p.Ser5Leu | p.S5L | Q9UGM6 | protein_coding | tolerated_low_confidence(0.6) | benign(0) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
WARS2 | SNV | Missense_Mutation | rs753188889 | c.317N>T | p.Pro106Leu | p.P106L | Q9UGM6 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WARS2 | SNV | Missense_Mutation | novel | c.224A>G | p.Asp75Gly | p.D75G | Q9UGM6 | protein_coding | tolerated(0.08) | possibly_damaging(0.788) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WARS2 | SNV | Missense_Mutation | c.712N>A | p.Val238Ile | p.V238I | Q9UGM6 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WARS2 | SNV | Missense_Mutation | rs750645277 | c.694C>A | p.Pro232Thr | p.P232T | Q9UGM6 | protein_coding | tolerated(0.07) | benign(0.444) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
WARS2 | SNV | Missense_Mutation | novel | c.1064N>C | p.Lys355Thr | p.K355T | Q9UGM6 | protein_coding | tolerated(0.05) | benign(0.027) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
WARS2 | SNV | Missense_Mutation | c.842N>T | p.Ala281Val | p.A281V | Q9UGM6 | protein_coding | tolerated(0.14) | possibly_damaging(0.581) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
WARS2 | SNV | Missense_Mutation | rs765994519 | c.755N>A | p.Arg252His | p.R252H | Q9UGM6 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
WARS2 | SNV | Missense_Mutation | novel | c.102G>T | p.Lys34Asn | p.K34N | Q9UGM6 | protein_coding | tolerated(0.5) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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