|
Gene: UTP18 |
Gene summary for UTP18 |
Gene summary. |
Gene information | Species | Human | Gene symbol | UTP18 | Gene ID | 51096 |
Gene name | UTP18 small subunit processome component | |
Gene Alias | CGI-48 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y5J1 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51096 | UTP18 | P56T-E | Human | Esophagus | ESCC | 1.64e-07 | 8.82e-01 | 0.1613 |
51096 | UTP18 | P57T-E | Human | Esophagus | ESCC | 1.54e-20 | 1.77e-01 | 0.0926 |
51096 | UTP18 | P61T-E | Human | Esophagus | ESCC | 1.82e-11 | 2.75e-01 | 0.099 |
51096 | UTP18 | P62T-E | Human | Esophagus | ESCC | 5.37e-30 | 6.85e-01 | 0.1302 |
51096 | UTP18 | P65T-E | Human | Esophagus | ESCC | 1.26e-16 | 2.40e-01 | 0.0978 |
51096 | UTP18 | P74T-E | Human | Esophagus | ESCC | 5.86e-25 | 8.70e-01 | 0.1479 |
51096 | UTP18 | P75T-E | Human | Esophagus | ESCC | 7.10e-24 | 4.84e-01 | 0.1125 |
51096 | UTP18 | P76T-E | Human | Esophagus | ESCC | 1.54e-35 | 8.33e-01 | 0.1207 |
51096 | UTP18 | P79T-E | Human | Esophagus | ESCC | 6.02e-31 | 4.79e-01 | 0.1154 |
51096 | UTP18 | P80T-E | Human | Esophagus | ESCC | 8.30e-55 | 1.75e+00 | 0.155 |
51096 | UTP18 | P82T-E | Human | Esophagus | ESCC | 3.01e-07 | 4.96e-01 | 0.1072 |
51096 | UTP18 | P83T-E | Human | Esophagus | ESCC | 1.37e-42 | 1.50e+00 | 0.1738 |
51096 | UTP18 | P84T-E | Human | Esophagus | ESCC | 2.97e-02 | 2.39e-01 | 0.0933 |
51096 | UTP18 | P89T-E | Human | Esophagus | ESCC | 8.87e-16 | 9.06e-01 | 0.1752 |
51096 | UTP18 | P91T-E | Human | Esophagus | ESCC | 3.23e-13 | 1.49e+00 | 0.1828 |
51096 | UTP18 | P107T-E | Human | Esophagus | ESCC | 3.07e-38 | 1.08e+00 | 0.171 |
51096 | UTP18 | P127T-E | Human | Esophagus | ESCC | 7.97e-12 | 8.49e-02 | 0.0826 |
51096 | UTP18 | P128T-E | Human | Esophagus | ESCC | 8.45e-33 | 1.16e+00 | 0.1241 |
51096 | UTP18 | P130T-E | Human | Esophagus | ESCC | 1.14e-59 | 1.32e+00 | 0.1676 |
51096 | UTP18 | HCC1_Meng | Human | Liver | HCC | 7.38e-71 | 1.84e-01 | 0.0246 |
Page: 1 2 3 4 5 6 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
Page: 1 2 3 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
UTP18 | cDC | Lung | AIS | TMEM63A,ZBTB33,CCL17, etc. | 2.27e-02 | |
UTP18 | D | Stomach | Healthy | CLEC2B,PHGR1,C16orf72, etc. | 9.42e-03 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTP18 | SNV | Missense_Mutation | novel | c.1565N>G | p.Ser522Cys | p.S522C | Q9Y5J1 | protein_coding | tolerated(0.14) | possibly_damaging(0.829) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
UTP18 | SNV | Missense_Mutation | novel | c.862A>G | p.Ile288Val | p.I288V | Q9Y5J1 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UTP18 | SNV | Missense_Mutation | c.1042N>A | p.Glu348Lys | p.E348K | Q9Y5J1 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UTP18 | SNV | Missense_Mutation | c.1609N>C | p.Ala537Pro | p.A537P | Q9Y5J1 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UTP18 | SNV | Missense_Mutation | novel | c.608N>C | p.Lys203Thr | p.K203T | Q9Y5J1 | protein_coding | tolerated(0.06) | benign(0.014) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UTP18 | insertion | Frame_Shift_Ins | novel | c.68_69insCTCAACAAGCAGT | p.Gly24SerfsTer100 | p.G24Sfs*100 | Q9Y5J1 | protein_coding | TCGA-EW-A6S9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UTP18 | insertion | In_Frame_Ins | novel | c.455_455+1insAATGGGATG | p.Met152delinsIleMetGlyTrp | p.M152delinsIMGW | Q9Y5J1 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
UTP18 | SNV | Missense_Mutation | novel | c.1486A>G | p.Lys496Glu | p.K496E | Q9Y5J1 | protein_coding | tolerated(0.23) | benign(0.372) | TCGA-A6-2678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
UTP18 | SNV | Missense_Mutation | c.233T>G | p.Leu78Arg | p.L78R | Q9Y5J1 | protein_coding | tolerated(0.08) | benign(0.259) | TCGA-AZ-5407-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UTP18 | SNV | Missense_Mutation | c.151C>T | p.Pro51Ser | p.P51S | Q9Y5J1 | protein_coding | tolerated(0.29) | benign(0.007) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |