Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UNKL

Gene summary for UNKL

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UNKL

Gene ID

64718

Gene nameunk like zinc finger
Gene AliasC16orf28
Cytomap16p13.3
Gene Typeprotein-coding
GO ID

GO:0006464

UniProtAcc

Q9H9P5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
64718UNKLP75T-EHumanEsophagusESCC4.84e-172.67e-010.1125
64718UNKLP76T-EHumanEsophagusESCC1.27e-099.59e-020.1207
64718UNKLP79T-EHumanEsophagusESCC2.77e-111.63e-010.1154
64718UNKLP80T-EHumanEsophagusESCC3.23e-061.02e-010.155
64718UNKLP82T-EHumanEsophagusESCC2.86e-062.78e-010.1072
64718UNKLP83T-EHumanEsophagusESCC2.10e-153.02e-010.1738
64718UNKLP84T-EHumanEsophagusESCC7.89e-041.60e-010.0933
64718UNKLP89T-EHumanEsophagusESCC4.99e-032.33e-010.1752
64718UNKLP107T-EHumanEsophagusESCC2.47e-163.14e-010.171
64718UNKLP127T-EHumanEsophagusESCC5.78e-065.87e-020.0826
64718UNKLP128T-EHumanEsophagusESCC1.40e-037.19e-020.1241
64718UNKLP130T-EHumanEsophagusESCC4.63e-069.50e-020.1676
64718UNKLHCC1_MengHumanLiverHCC5.09e-224.21e-020.0246
64718UNKLHCC2_MengHumanLiverHCC2.07e-042.53e-020.0107
64718UNKLHCC1HumanLiverHCC2.79e-071.01e+000.5336
64718UNKLHCC2HumanLiverHCC9.62e-142.20e+000.5341
64718UNKLHCC5HumanLiverHCC1.01e-101.42e+000.4932
64718UNKLS014HumanLiverHCC4.12e-052.54e-010.2254
64718UNKLS015HumanLiverHCC2.46e-032.12e-010.2375
64718UNKLS016HumanLiverHCC8.22e-061.98e-010.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UNKLSNVMissense_Mutationnovelc.534N>Cp.Gln178Hisp.Q178HQ9H9P5protein_codingdeleterious_low_confidence(0)benign(0.03)TCGA-C8-A1HM-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinCR
UNKLSNVMissense_Mutationnovelc.814G>Ap.Gly272Argp.G272RQ9H9P5protein_codingprobably_damaging(0.979)TCGA-C5-A8YQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
UNKLSNVMissense_Mutationc.569N>Cp.Lys190Thrp.K190TQ9H9P5protein_codingtolerated_low_confidence(0.07)benign(0.09)TCGA-A6-6653-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
UNKLSNVMissense_Mutationc.1579C>Ap.Pro527Thrp.P527Tprotein_codingtolerated(0.05)benign(0.024)TCGA-A6-6780-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
UNKLSNVMissense_Mutationrs574875280c.524C>Tp.Pro175Leup.P175LQ9H9P5protein_codingtolerated_low_confidence(0.22)benign(0.149)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
UNKLSNVMissense_Mutationc.340N>Tp.Arg114Cysp.R114CQ9H9P5protein_codingdeleterious(0)probably_damaging(1)TCGA-G4-6304-01Colorectumcolon adenocarcinomaFemale>=65I/IIChemotherapyfluorouracilPD
UNKLSNVMissense_Mutationc.428N>Ap.Gly143Aspp.G143DQ9H9P5protein_codingdeleterious(0)probably_damaging(0.996)TCGA-AG-A02N-01Colorectumrectum adenocarcinomaMale>=65I/IIChemotherapyfolinicCR
UNKLSNVMissense_Mutationnovelc.1546N>Ap.Gly516Serp.G516Sprotein_codingtolerated(0.67)benign(0.058)TCGA-A5-A2K3-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinSD
UNKLSNVMissense_Mutationnovelc.535N>Tp.Pro179Serp.P179SQ9H9P5protein_codingtolerated_low_confidence(0.3)benign(0.042)TCGA-A5-A7WJ-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
UNKLSNVMissense_Mutationc.409N>Tp.His137Tyrp.H137YQ9H9P5protein_codingtolerated(0.12)possibly_damaging(0.879)TCGA-AP-A1DP-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapypaclitaxelPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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