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Gene: UNKL |
Gene summary for UNKL |
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Gene information | Species | Human | Gene symbol | UNKL | Gene ID | 64718 |
Gene name | unk like zinc finger | |
Gene Alias | C16orf28 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9H9P5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64718 | UNKL | P75T-E | Human | Esophagus | ESCC | 4.84e-17 | 2.67e-01 | 0.1125 |
64718 | UNKL | P76T-E | Human | Esophagus | ESCC | 1.27e-09 | 9.59e-02 | 0.1207 |
64718 | UNKL | P79T-E | Human | Esophagus | ESCC | 2.77e-11 | 1.63e-01 | 0.1154 |
64718 | UNKL | P80T-E | Human | Esophagus | ESCC | 3.23e-06 | 1.02e-01 | 0.155 |
64718 | UNKL | P82T-E | Human | Esophagus | ESCC | 2.86e-06 | 2.78e-01 | 0.1072 |
64718 | UNKL | P83T-E | Human | Esophagus | ESCC | 2.10e-15 | 3.02e-01 | 0.1738 |
64718 | UNKL | P84T-E | Human | Esophagus | ESCC | 7.89e-04 | 1.60e-01 | 0.0933 |
64718 | UNKL | P89T-E | Human | Esophagus | ESCC | 4.99e-03 | 2.33e-01 | 0.1752 |
64718 | UNKL | P107T-E | Human | Esophagus | ESCC | 2.47e-16 | 3.14e-01 | 0.171 |
64718 | UNKL | P127T-E | Human | Esophagus | ESCC | 5.78e-06 | 5.87e-02 | 0.0826 |
64718 | UNKL | P128T-E | Human | Esophagus | ESCC | 1.40e-03 | 7.19e-02 | 0.1241 |
64718 | UNKL | P130T-E | Human | Esophagus | ESCC | 4.63e-06 | 9.50e-02 | 0.1676 |
64718 | UNKL | HCC1_Meng | Human | Liver | HCC | 5.09e-22 | 4.21e-02 | 0.0246 |
64718 | UNKL | HCC2_Meng | Human | Liver | HCC | 2.07e-04 | 2.53e-02 | 0.0107 |
64718 | UNKL | HCC1 | Human | Liver | HCC | 2.79e-07 | 1.01e+00 | 0.5336 |
64718 | UNKL | HCC2 | Human | Liver | HCC | 9.62e-14 | 2.20e+00 | 0.5341 |
64718 | UNKL | HCC5 | Human | Liver | HCC | 1.01e-10 | 1.42e+00 | 0.4932 |
64718 | UNKL | S014 | Human | Liver | HCC | 4.12e-05 | 2.54e-01 | 0.2254 |
64718 | UNKL | S015 | Human | Liver | HCC | 2.46e-03 | 2.12e-01 | 0.2375 |
64718 | UNKL | S016 | Human | Liver | HCC | 8.22e-06 | 1.98e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNKL | SNV | Missense_Mutation | novel | c.534N>C | p.Gln178His | p.Q178H | Q9H9P5 | protein_coding | deleterious_low_confidence(0) | benign(0.03) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
UNKL | SNV | Missense_Mutation | novel | c.814G>A | p.Gly272Arg | p.G272R | Q9H9P5 | protein_coding | probably_damaging(0.979) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
UNKL | SNV | Missense_Mutation | c.569N>C | p.Lys190Thr | p.K190T | Q9H9P5 | protein_coding | tolerated_low_confidence(0.07) | benign(0.09) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UNKL | SNV | Missense_Mutation | c.1579C>A | p.Pro527Thr | p.P527T | protein_coding | tolerated(0.05) | benign(0.024) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
UNKL | SNV | Missense_Mutation | rs574875280 | c.524C>T | p.Pro175Leu | p.P175L | Q9H9P5 | protein_coding | tolerated_low_confidence(0.22) | benign(0.149) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNKL | SNV | Missense_Mutation | c.340N>T | p.Arg114Cys | p.R114C | Q9H9P5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
UNKL | SNV | Missense_Mutation | c.428N>A | p.Gly143Asp | p.G143D | Q9H9P5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
UNKL | SNV | Missense_Mutation | novel | c.1546N>A | p.Gly516Ser | p.G516S | protein_coding | tolerated(0.67) | benign(0.058) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
UNKL | SNV | Missense_Mutation | novel | c.535N>T | p.Pro179Ser | p.P179S | Q9H9P5 | protein_coding | tolerated_low_confidence(0.3) | benign(0.042) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNKL | SNV | Missense_Mutation | c.409N>T | p.His137Tyr | p.H137Y | Q9H9P5 | protein_coding | tolerated(0.12) | possibly_damaging(0.879) | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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