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Gene: UGP2 |
Gene summary for UGP2 |
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Gene information | Species | Human | Gene symbol | UGP2 | Gene ID | 7360 |
Gene name | UDP-glucose pyrophosphorylase 2 | |
Gene Alias | DEE83 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | A0A140VKE1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7360 | UGP2 | LZE7T | Human | Esophagus | ESCC | 2.25e-13 | 7.07e-01 | 0.0667 |
7360 | UGP2 | LZE8T | Human | Esophagus | ESCC | 1.13e-06 | 3.36e-01 | 0.067 |
7360 | UGP2 | LZE20T | Human | Esophagus | ESCC | 2.78e-09 | 5.09e-01 | 0.0662 |
7360 | UGP2 | LZE21D1 | Human | Esophagus | HGIN | 2.31e-05 | 6.08e-01 | 0.0632 |
7360 | UGP2 | LZE22T | Human | Esophagus | ESCC | 3.05e-09 | 7.08e-01 | 0.068 |
7360 | UGP2 | LZE24T | Human | Esophagus | ESCC | 9.29e-10 | 4.54e-01 | 0.0596 |
7360 | UGP2 | LZE22D3 | Human | Esophagus | HGIN | 5.44e-03 | 2.75e-01 | 0.0653 |
7360 | UGP2 | LZE6T | Human | Esophagus | ESCC | 4.37e-07 | 7.23e-01 | 0.0845 |
7360 | UGP2 | P1T-E | Human | Esophagus | ESCC | 1.40e-10 | 7.04e-01 | 0.0875 |
7360 | UGP2 | P2T-E | Human | Esophagus | ESCC | 2.71e-42 | 9.28e-01 | 0.1177 |
7360 | UGP2 | P4T-E | Human | Esophagus | ESCC | 1.21e-18 | 6.05e-01 | 0.1323 |
7360 | UGP2 | P5T-E | Human | Esophagus | ESCC | 4.63e-13 | 2.22e-01 | 0.1327 |
7360 | UGP2 | P8T-E | Human | Esophagus | ESCC | 3.31e-31 | 6.96e-01 | 0.0889 |
7360 | UGP2 | P9T-E | Human | Esophagus | ESCC | 3.62e-16 | 4.58e-01 | 0.1131 |
7360 | UGP2 | P10T-E | Human | Esophagus | ESCC | 1.46e-49 | 1.06e+00 | 0.116 |
7360 | UGP2 | P11T-E | Human | Esophagus | ESCC | 2.26e-14 | 8.35e-01 | 0.1426 |
7360 | UGP2 | P12T-E | Human | Esophagus | ESCC | 4.92e-23 | 4.79e-01 | 0.1122 |
7360 | UGP2 | P15T-E | Human | Esophagus | ESCC | 4.30e-47 | 1.16e+00 | 0.1149 |
7360 | UGP2 | P16T-E | Human | Esophagus | ESCC | 1.35e-42 | 8.20e-01 | 0.1153 |
7360 | UGP2 | P17T-E | Human | Esophagus | ESCC | 9.50e-07 | 4.29e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0009225 | Colorectum | AD | nucleotide-sugar metabolic process | 16/3918 | 36/18723 | 1.27e-03 | 1.12e-02 | 16 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00159802 | Colorectum | MSS | energy derivation by oxidation of organic compounds | 131/3467 | 318/18723 | 2.60e-21 | 2.70e-18 | 131 |
GO:00092252 | Colorectum | MSS | nucleotide-sugar metabolic process | 14/3467 | 36/18723 | 3.40e-03 | 2.56e-02 | 14 |
GO:00060914 | Colorectum | FAP | generation of precursor metabolites and energy | 128/2622 | 490/18723 | 5.58e-13 | 4.28e-10 | 128 |
GO:00159804 | Colorectum | FAP | energy derivation by oxidation of organic compounds | 85/2622 | 318/18723 | 1.36e-09 | 2.77e-07 | 85 |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00060915 | Colorectum | CRC | generation of precursor metabolites and energy | 80/2078 | 490/18723 | 2.55e-04 | 4.16e-03 | 80 |
GO:00442622 | Colorectum | CRC | cellular carbohydrate metabolic process | 49/2078 | 283/18723 | 1.06e-03 | 1.24e-02 | 49 |
GO:00092253 | Colorectum | CRC | nucleotide-sugar metabolic process | 10/2078 | 36/18723 | 4.68e-03 | 3.62e-02 | 10 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
GO:001598020 | Esophagus | HGIN | energy derivation by oxidation of organic compounds | 105/2587 | 318/18723 | 1.16e-18 | 4.99e-16 | 105 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:00092256 | Esophagus | ESCC | nucleotide-sugar metabolic process | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00052 | Colorectum | FAP | Galactose metabolism | 12/1404 | 32/8465 | 3.61e-03 | 1.53e-02 | 9.29e-03 | 12 |
hsa01250 | Colorectum | FAP | Biosynthesis of nucleotide sugars | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa000521 | Colorectum | FAP | Galactose metabolism | 12/1404 | 32/8465 | 3.61e-03 | 1.53e-02 | 9.29e-03 | 12 |
hsa012501 | Colorectum | FAP | Biosynthesis of nucleotide sugars | 13/1404 | 37/8465 | 4.79e-03 | 1.91e-02 | 1.16e-02 | 13 |
hsa012502 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa012503 | Colorectum | CRC | Biosynthesis of nucleotide sugars | 12/1091 | 37/8465 | 1.66e-03 | 1.20e-02 | 8.16e-03 | 12 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa012505 | Esophagus | ESCC | Biosynthesis of nucleotide sugars | 28/4205 | 37/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 28 |
hsa005202 | Esophagus | ESCC | Amino sugar and nucleotide sugar metabolism | 35/4205 | 49/8465 | 1.60e-03 | 4.88e-03 | 2.50e-03 | 35 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0125012 | Esophagus | ESCC | Biosynthesis of nucleotide sugars | 28/4205 | 37/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 28 |
hsa0052011 | Esophagus | ESCC | Amino sugar and nucleotide sugar metabolism | 35/4205 | 49/8465 | 1.60e-03 | 4.88e-03 | 2.50e-03 | 35 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa00520 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa012504 | Oral cavity | OSCC | Biosynthesis of nucleotide sugars | 25/3704 | 37/8465 | 2.93e-03 | 7.49e-03 | 3.81e-03 | 25 |
hsa005201 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UGP2 | SNV | Missense_Mutation | c.925N>G | p.Gln309Glu | p.Q309E | Q16851 | protein_coding | deleterious(0) | possibly_damaging(0.746) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UGP2 | SNV | Missense_Mutation | c.1387N>T | p.Asp463Tyr | p.D463Y | Q16851 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AR-A24U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
UGP2 | SNV | Missense_Mutation | c.1177C>A | p.Leu393Met | p.L393M | Q16851 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
UGP2 | SNV | Missense_Mutation | c.170N>A | p.Gly57Glu | p.G57E | Q16851 | protein_coding | tolerated(0.12) | possibly_damaging(0.865) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UGP2 | insertion | Frame_Shift_Ins | novel | c.493_494insA | p.Phe165TyrfsTer2 | p.F165Yfs*2 | Q16851 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
UGP2 | insertion | Frame_Shift_Ins | novel | c.495_496insTTTTCCATCTCCTTATCCTATTGCCTAGTATGGTGCTGGC | p.Asn166PhefsTer17 | p.N166Ffs*17 | Q16851 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
UGP2 | SNV | Missense_Mutation | c.301N>C | p.Ile101Leu | p.I101L | Q16851 | protein_coding | tolerated(0.46) | benign(0.013) | TCGA-AA-3679-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | SD | |
UGP2 | SNV | Missense_Mutation | c.859N>T | p.Arg287Cys | p.R287C | Q16851 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UGP2 | SNV | Missense_Mutation | novel | c.73C>T | p.Arg25Trp | p.R25W | Q16851 | protein_coding | tolerated(0.06) | possibly_damaging(0.895) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UGP2 | SNV | Missense_Mutation | c.770C>T | p.Ala257Val | p.A257V | Q16851 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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