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Gene: UCP2 |
Gene summary for UCP2 |
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Gene information | Species | Human | Gene symbol | UCP2 | Gene ID | 7351 |
Gene name | uncoupling protein 2 | |
Gene Alias | BMIQ4 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R5N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7351 | UCP2 | EEC-subject3 | Human | Endometrium | EEC | 2.25e-08 | -1.22e-01 | -0.2525 |
7351 | UCP2 | EEC-subject5 | Human | Endometrium | EEC | 5.14e-06 | 4.18e-01 | -0.249 |
7351 | UCP2 | GSM5276934 | Human | Endometrium | EEC | 1.42e-04 | -1.87e-01 | -0.0913 |
7351 | UCP2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.74e-23 | 6.31e-01 | -0.1869 |
7351 | UCP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.18e-11 | 4.53e-01 | -0.1875 |
7351 | UCP2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.39e-29 | 7.29e-01 | -0.1883 |
7351 | UCP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.11e-04 | 3.23e-01 | -0.1934 |
7351 | UCP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.12e-37 | 9.03e-01 | -0.1917 |
7351 | UCP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.22e-42 | 8.94e-01 | -0.1916 |
7351 | UCP2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.86e-12 | 5.53e-01 | -0.1269 |
7351 | UCP2 | LZE2T | Human | Esophagus | ESCC | 3.59e-04 | 4.87e-01 | 0.082 |
7351 | UCP2 | LZE4T | Human | Esophagus | ESCC | 2.19e-09 | 5.03e-01 | 0.0811 |
7351 | UCP2 | LZE7T | Human | Esophagus | ESCC | 5.38e-17 | 9.30e-01 | 0.0667 |
7351 | UCP2 | LZE8T | Human | Esophagus | ESCC | 1.63e-05 | 4.70e-01 | 0.067 |
7351 | UCP2 | LZE20T | Human | Esophagus | ESCC | 1.91e-07 | 3.62e-01 | 0.0662 |
7351 | UCP2 | LZE22T | Human | Esophagus | ESCC | 4.10e-14 | 8.28e-01 | 0.068 |
7351 | UCP2 | LZE24T | Human | Esophagus | ESCC | 5.48e-37 | 1.25e+00 | 0.0596 |
7351 | UCP2 | LZE6T | Human | Esophagus | ESCC | 4.30e-12 | 6.57e-01 | 0.0845 |
7351 | UCP2 | P2T-E | Human | Esophagus | ESCC | 1.86e-03 | 2.26e-01 | 0.1177 |
7351 | UCP2 | P4T-E | Human | Esophagus | ESCC | 1.03e-43 | 1.21e+00 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19026008 | Breast | Precancer | proton transmembrane transport | 39/1080 | 157/18723 | 4.18e-15 | 1.18e-12 | 39 |
GO:00069799 | Breast | Precancer | response to oxidative stress | 70/1080 | 446/18723 | 1.59e-14 | 4.26e-12 | 70 |
GO:00362939 | Breast | Precancer | response to decreased oxygen levels | 53/1080 | 322/18723 | 4.09e-12 | 6.84e-10 | 53 |
GO:00016669 | Breast | Precancer | response to hypoxia | 51/1080 | 307/18723 | 7.33e-12 | 1.11e-09 | 51 |
GO:00704829 | Breast | Precancer | response to oxygen levels | 55/1080 | 347/18723 | 7.47e-12 | 1.11e-09 | 55 |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:00003029 | Breast | Precancer | response to reactive oxygen species | 38/1080 | 222/18723 | 1.47e-09 | 1.23e-07 | 38 |
GO:19905427 | Breast | Precancer | mitochondrial transmembrane transport | 22/1080 | 102/18723 | 6.38e-08 | 3.80e-06 | 22 |
GO:00518816 | Breast | Precancer | regulation of mitochondrial membrane potential | 18/1080 | 74/18723 | 1.45e-07 | 7.82e-06 | 18 |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00075688 | Breast | Precancer | aging | 41/1080 | 339/18723 | 5.95e-06 | 1.71e-04 | 41 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00974216 | Breast | Precancer | liver regeneration | 10/1080 | 35/18723 | 1.91e-05 | 4.52e-04 | 10 |
GO:00342849 | Breast | Precancer | response to monosaccharide | 29/1080 | 225/18723 | 4.19e-05 | 9.00e-04 | 29 |
GO:00097439 | Breast | Precancer | response to carbohydrate | 31/1080 | 253/18723 | 6.15e-05 | 1.25e-03 | 31 |
GO:00425938 | Breast | Precancer | glucose homeostasis | 31/1080 | 258/18723 | 8.89e-05 | 1.69e-03 | 31 |
GO:00335008 | Breast | Precancer | carbohydrate homeostasis | 31/1080 | 259/18723 | 9.56e-05 | 1.79e-03 | 31 |
GO:00311004 | Breast | Precancer | animal organ regeneration | 14/1080 | 76/18723 | 9.92e-05 | 1.83e-03 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UCP2 | SNV | Missense_Mutation | novel | c.22N>A | p.Asp8Asn | p.D8N | P55851 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A2-A3XZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
UCP2 | SNV | Missense_Mutation | c.452G>C | p.Gly151Ala | p.G151A | P55851 | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UCP2 | SNV | Missense_Mutation | c.94N>A | p.Phe32Ile | p.F32I | P55851 | protein_coding | tolerated(0.51) | possibly_damaging(0.643) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
UCP2 | SNV | Missense_Mutation | c.52N>A | p.Leu18Ile | p.L18I | P55851 | protein_coding | tolerated(0.23) | benign(0.031) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR | |
UCP2 | SNV | Missense_Mutation | c.488N>T | p.Tyr163Phe | p.Y163F | P55851 | protein_coding | deleterious(0) | possibly_damaging(0.738) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
UCP2 | deletion | Frame_Shift_Del | rs770840871 | c.143_144delAG | p.Gln48ArgfsTer25 | p.Q48Rfs*25 | P55851 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
UCP2 | SNV | Missense_Mutation | rs780835346 | c.292G>A | p.Gly98Ser | p.G98S | P55851 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UCP2 | SNV | Missense_Mutation | rs781271646 | c.154N>T | p.Arg52Cys | p.R52C | P55851 | protein_coding | deleterious(0.05) | benign(0.09) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
UCP2 | deletion | Frame_Shift_Del | c.32delN | p.Pro11LeufsTer5 | p.P11Lfs*5 | P55851 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
UCP2 | SNV | Missense_Mutation | rs145061662 | c.263G>A | p.Arg88His | p.R88H | P55851 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | INTRALIPID | SOYBEAN OIL | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | BRL49653 | 9299560 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | HEPARIN | HEPARIN | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | ANTIOXIDANT | 15642337 | ||
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | TRIIODOTHYRONINE | LIOTHYRONINE SODIUM | 9428737,10444435 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | SALINE | SODIUM CHLORIDE | 10868951 | |
7351 | UCP2 | TRANSPORTER, DRUGGABLE GENOME | CL-316,243 |
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