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Gene: UBR7 |
Gene summary for UBR7 |
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Gene information | Species | Human | Gene symbol | UBR7 | Gene ID | 55148 |
Gene name | ubiquitin protein ligase E3 component n-recognin 7 | |
Gene Alias | C14orf130 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N806 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55148 | UBR7 | P54T-E | Human | Esophagus | ESCC | 1.12e-13 | 2.70e-01 | 0.0975 |
55148 | UBR7 | P56T-E | Human | Esophagus | ESCC | 2.64e-08 | 4.77e-01 | 0.1613 |
55148 | UBR7 | P57T-E | Human | Esophagus | ESCC | 3.44e-14 | 3.30e-01 | 0.0926 |
55148 | UBR7 | P61T-E | Human | Esophagus | ESCC | 3.61e-32 | 6.69e-01 | 0.099 |
55148 | UBR7 | P62T-E | Human | Esophagus | ESCC | 2.05e-21 | 4.04e-01 | 0.1302 |
55148 | UBR7 | P65T-E | Human | Esophagus | ESCC | 8.55e-10 | 3.03e-01 | 0.0978 |
55148 | UBR7 | P74T-E | Human | Esophagus | ESCC | 1.97e-17 | 5.98e-01 | 0.1479 |
55148 | UBR7 | P75T-E | Human | Esophagus | ESCC | 7.00e-16 | 3.47e-01 | 0.1125 |
55148 | UBR7 | P76T-E | Human | Esophagus | ESCC | 9.23e-12 | 2.11e-01 | 0.1207 |
55148 | UBR7 | P79T-E | Human | Esophagus | ESCC | 1.50e-18 | 4.21e-01 | 0.1154 |
55148 | UBR7 | P80T-E | Human | Esophagus | ESCC | 3.41e-09 | 2.69e-01 | 0.155 |
55148 | UBR7 | P82T-E | Human | Esophagus | ESCC | 2.03e-03 | 1.73e-01 | 0.1072 |
55148 | UBR7 | P83T-E | Human | Esophagus | ESCC | 5.52e-14 | 4.21e-01 | 0.1738 |
55148 | UBR7 | P84T-E | Human | Esophagus | ESCC | 5.50e-07 | 2.80e-01 | 0.0933 |
55148 | UBR7 | P89T-E | Human | Esophagus | ESCC | 1.58e-09 | 4.91e-01 | 0.1752 |
55148 | UBR7 | P91T-E | Human | Esophagus | ESCC | 9.96e-12 | 1.42e+00 | 0.1828 |
55148 | UBR7 | P107T-E | Human | Esophagus | ESCC | 1.71e-11 | 3.21e-01 | 0.171 |
55148 | UBR7 | P127T-E | Human | Esophagus | ESCC | 2.41e-09 | 2.12e-01 | 0.0826 |
55148 | UBR7 | P128T-E | Human | Esophagus | ESCC | 2.48e-17 | 4.62e-01 | 0.1241 |
55148 | UBR7 | P130T-E | Human | Esophagus | ESCC | 2.11e-13 | 2.68e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR7 | SNV | Missense_Mutation | novel | c.1144G>A | p.Glu382Lys | p.E382K | Q8N806 | protein_coding | deleterious(0.03) | benign(0.186) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
UBR7 | SNV | Missense_Mutation | rs267604099 | c.292N>T | p.Arg98Cys | p.R98C | Q8N806 | protein_coding | tolerated(0.06) | probably_damaging(0.957) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UBR7 | SNV | Missense_Mutation | novel | c.772N>A | p.Glu258Lys | p.E258K | Q8N806 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-E2-A1IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
UBR7 | deletion | Frame_Shift_Del | c.990delN | p.Leu331Ter | p.L331* | Q8N806 | protein_coding | TCGA-E2-A14T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
UBR7 | SNV | Missense_Mutation | novel | c.169N>T | p.Ala57Ser | p.A57S | Q8N806 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UBR7 | SNV | Missense_Mutation | novel | c.800N>G | p.Ser267Cys | p.S267C | Q8N806 | protein_coding | tolerated(0.16) | benign(0.353) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
UBR7 | SNV | Missense_Mutation | novel | c.1273N>G | p.Ser425Gly | p.S425G | Q8N806 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.746) | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBR7 | insertion | Nonsense_Mutation | novel | c.1111_1112insCTCTGGAGTGTGTCT | p.Glu371delinsAlaLeuGluCysValTer | p.E371delinsALECV* | Q8N806 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
UBR7 | SNV | Missense_Mutation | c.470T>A | p.Val157Asp | p.V157D | Q8N806 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBR7 | SNV | Missense_Mutation | rs372446489 | c.638G>A | p.Arg213Gln | p.R213Q | Q8N806 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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