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Gene: UBE3B |
Gene summary for UBE3B |
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Gene information | Species | Human | Gene symbol | UBE3B | Gene ID | 89910 |
Gene name | ubiquitin protein ligase E3B | |
Gene Alias | BPIDS | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q7Z3V4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89910 | UBE3B | P62T-E | Human | Esophagus | ESCC | 6.69e-23 | 3.32e-01 | 0.1302 |
89910 | UBE3B | P65T-E | Human | Esophagus | ESCC | 4.22e-10 | 1.73e-01 | 0.0978 |
89910 | UBE3B | P74T-E | Human | Esophagus | ESCC | 5.29e-09 | 2.96e-01 | 0.1479 |
89910 | UBE3B | P75T-E | Human | Esophagus | ESCC | 1.99e-33 | 5.63e-01 | 0.1125 |
89910 | UBE3B | P76T-E | Human | Esophagus | ESCC | 6.85e-10 | 1.83e-01 | 0.1207 |
89910 | UBE3B | P79T-E | Human | Esophagus | ESCC | 1.06e-17 | 2.90e-01 | 0.1154 |
89910 | UBE3B | P80T-E | Human | Esophagus | ESCC | 9.23e-06 | 2.46e-01 | 0.155 |
89910 | UBE3B | P82T-E | Human | Esophagus | ESCC | 1.05e-04 | 3.69e-01 | 0.1072 |
89910 | UBE3B | P83T-E | Human | Esophagus | ESCC | 7.84e-10 | 4.15e-01 | 0.1738 |
89910 | UBE3B | P89T-E | Human | Esophagus | ESCC | 3.99e-08 | 5.09e-01 | 0.1752 |
89910 | UBE3B | P91T-E | Human | Esophagus | ESCC | 4.29e-03 | 6.81e-01 | 0.1828 |
89910 | UBE3B | P107T-E | Human | Esophagus | ESCC | 4.24e-25 | 4.86e-01 | 0.171 |
89910 | UBE3B | P127T-E | Human | Esophagus | ESCC | 8.69e-09 | 1.63e-01 | 0.0826 |
89910 | UBE3B | P128T-E | Human | Esophagus | ESCC | 4.93e-09 | 3.67e-01 | 0.1241 |
89910 | UBE3B | P130T-E | Human | Esophagus | ESCC | 7.72e-41 | 7.01e-01 | 0.1676 |
89910 | UBE3B | HCC1_Meng | Human | Liver | HCC | 4.63e-34 | 2.15e-02 | 0.0246 |
89910 | UBE3B | HCC2_Meng | Human | Liver | HCC | 1.07e-08 | 5.20e-02 | 0.0107 |
89910 | UBE3B | HCC1 | Human | Liver | HCC | 1.23e-09 | 3.55e+00 | 0.5336 |
89910 | UBE3B | HCC2 | Human | Liver | HCC | 1.48e-12 | 3.20e+00 | 0.5341 |
89910 | UBE3B | S014 | Human | Liver | HCC | 1.61e-16 | 4.89e-01 | 0.2254 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE3B | SNV | Missense_Mutation | rs774422074 | c.2141N>C | p.Phe714Ser | p.F714S | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | rs748411631 | c.743A>G | p.Asn248Ser | p.N248S | Q7Z3V4 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-A7-A4SA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
UBE3B | SNV | Missense_Mutation | novel | c.2633N>C | p.Ser878Thr | p.S878T | Q7Z3V4 | protein_coding | tolerated(0.27) | benign(0.354) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | novel | c.267N>G | p.Ile89Met | p.I89M | Q7Z3V4 | protein_coding | tolerated(0.27) | benign(0.006) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | c.2215A>T | p.Ile739Phe | p.I739F | Q7Z3V4 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBE3B | SNV | Missense_Mutation | c.1834C>G | p.Pro612Ala | p.P612A | Q7Z3V4 | protein_coding | deleterious(0.01) | possibly_damaging(0.835) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
UBE3B | SNV | Missense_Mutation | novel | c.3177C>G | p.Ile1059Met | p.I1059M | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
UBE3B | SNV | Missense_Mutation | c.703C>G | p.Leu235Val | p.L235V | Q7Z3V4 | protein_coding | tolerated(0.1) | benign(0.343) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
UBE3B | insertion | Nonsense_Mutation | novel | c.2122_2123insAGCACTCATTCAAAAGCAGGTGAGAACGGCTCCT | p.Gly708GlufsTer8 | p.G708Efs*8 | Q7Z3V4 | protein_coding | TCGA-A8-A0AB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
UBE3B | insertion | Nonsense_Mutation | novel | c.1544_1545insTTCCCTAATATAGTCCTCTGAATTTTTACCATTGTG | p.Leu515_Asn516insSerLeuIleTerSerSerGluPheLeuProLeuTrp | p.L515_N516insSLI*SSEFLPLW | Q7Z3V4 | protein_coding | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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