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Gene: TXLNA |
Gene summary for TXLNA |
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Gene information | Species | Human | Gene symbol | TXLNA | Gene ID | 200081 |
Gene name | taxilin alpha | |
Gene Alias | IL14 | |
Cytomap | 1p35.2 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P40222 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200081 | TXLNA | P57T-E | Human | Esophagus | ESCC | 3.10e-12 | 2.02e-01 | 0.0926 |
200081 | TXLNA | P61T-E | Human | Esophagus | ESCC | 5.58e-09 | 2.33e-01 | 0.099 |
200081 | TXLNA | P62T-E | Human | Esophagus | ESCC | 3.96e-19 | 3.15e-01 | 0.1302 |
200081 | TXLNA | P65T-E | Human | Esophagus | ESCC | 6.43e-24 | 1.41e-01 | 0.0978 |
200081 | TXLNA | P74T-E | Human | Esophagus | ESCC | 1.64e-12 | 4.75e-01 | 0.1479 |
200081 | TXLNA | P75T-E | Human | Esophagus | ESCC | 1.62e-16 | 4.23e-01 | 0.1125 |
200081 | TXLNA | P76T-E | Human | Esophagus | ESCC | 4.15e-17 | 2.65e-01 | 0.1207 |
200081 | TXLNA | P79T-E | Human | Esophagus | ESCC | 3.53e-17 | 3.05e-01 | 0.1154 |
200081 | TXLNA | P80T-E | Human | Esophagus | ESCC | 3.07e-09 | 2.84e-01 | 0.155 |
200081 | TXLNA | P82T-E | Human | Esophagus | ESCC | 2.81e-10 | 5.88e-01 | 0.1072 |
200081 | TXLNA | P83T-E | Human | Esophagus | ESCC | 4.34e-14 | 3.61e-01 | 0.1738 |
200081 | TXLNA | P84T-E | Human | Esophagus | ESCC | 4.69e-05 | 1.74e-01 | 0.0933 |
200081 | TXLNA | P89T-E | Human | Esophagus | ESCC | 2.14e-05 | 3.67e-01 | 0.1752 |
200081 | TXLNA | P91T-E | Human | Esophagus | ESCC | 6.25e-13 | 8.72e-01 | 0.1828 |
200081 | TXLNA | P104T-E | Human | Esophagus | ESCC | 6.65e-05 | 2.51e-01 | 0.0931 |
200081 | TXLNA | P107T-E | Human | Esophagus | ESCC | 5.86e-22 | 4.64e-01 | 0.171 |
200081 | TXLNA | P127T-E | Human | Esophagus | ESCC | 2.44e-11 | 1.71e-01 | 0.0826 |
200081 | TXLNA | P128T-E | Human | Esophagus | ESCC | 5.55e-17 | 5.96e-01 | 0.1241 |
200081 | TXLNA | P130T-E | Human | Esophagus | ESCC | 2.50e-30 | 6.60e-01 | 0.1676 |
200081 | TXLNA | HCC1_Meng | Human | Liver | HCC | 4.77e-66 | 1.39e-01 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXLNA | SNV | Missense_Mutation | novel | c.651N>C | p.Gln217His | p.Q217H | P40222 | protein_coding | deleterious(0.02) | possibly_damaging(0.823) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
TXLNA | SNV | Missense_Mutation | rs746949166 | c.400N>A | p.Glu134Lys | p.E134K | P40222 | protein_coding | tolerated(0.07) | probably_damaging(0.985) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
TXLNA | SNV | Missense_Mutation | c.995T>A | p.Leu332Gln | p.L332Q | P40222 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TXLNA | insertion | Frame_Shift_Ins | novel | c.1502_1503insACCA | p.Glu502ProfsTer2 | p.E502Pfs*2 | P40222 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TXLNA | insertion | Frame_Shift_Ins | novel | c.1504_1505insCCTGGCTAATTTTTTCTTTCTTTTTTTTTTGTATTTTT | p.Glu502AlafsTer79 | p.E502Afs*79 | P40222 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
TXLNA | insertion | Nonsense_Mutation | novel | c.250_251insCTTTTCCGTAAAATGG | p.Ser84ThrfsTer4 | p.S84Tfs*4 | P40222 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TXLNA | deletion | Frame_Shift_Del | novel | c.355delA | p.Arg119GlyfsTer10 | p.R119Gfs*10 | P40222 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TXLNA | SNV | Missense_Mutation | rs780644587 | c.205C>T | p.Arg69Cys | p.R69C | P40222 | protein_coding | tolerated(0.21) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TXLNA | SNV | Missense_Mutation | rs776440607 | c.809G>A | p.Arg270His | p.R270H | P40222 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TXLNA | SNV | Missense_Mutation | novel | c.1378C>A | p.Leu460Met | p.L460M | P40222 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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