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Gene: TTLL12 |
Gene summary for TTLL12 |
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Gene information | Species | Human | Gene symbol | TTLL12 | Gene ID | 23170 |
Gene name | tubulin tyrosine ligase like 12 | |
Gene Alias | dJ526I14.2 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R4U3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23170 | TTLL12 | P20T-E | Human | Esophagus | ESCC | 1.09e-21 | 6.71e-01 | 0.1124 |
23170 | TTLL12 | P21T-E | Human | Esophagus | ESCC | 4.84e-21 | 4.49e-01 | 0.1617 |
23170 | TTLL12 | P22T-E | Human | Esophagus | ESCC | 3.36e-34 | 6.19e-01 | 0.1236 |
23170 | TTLL12 | P23T-E | Human | Esophagus | ESCC | 2.18e-31 | 9.39e-01 | 0.108 |
23170 | TTLL12 | P24T-E | Human | Esophagus | ESCC | 3.46e-16 | 5.60e-01 | 0.1287 |
23170 | TTLL12 | P26T-E | Human | Esophagus | ESCC | 6.04e-25 | 6.29e-01 | 0.1276 |
23170 | TTLL12 | P27T-E | Human | Esophagus | ESCC | 9.02e-27 | 6.18e-01 | 0.1055 |
23170 | TTLL12 | P28T-E | Human | Esophagus | ESCC | 2.46e-36 | 7.48e-01 | 0.1149 |
23170 | TTLL12 | P30T-E | Human | Esophagus | ESCC | 4.84e-36 | 1.30e+00 | 0.137 |
23170 | TTLL12 | P31T-E | Human | Esophagus | ESCC | 1.74e-31 | 5.51e-01 | 0.1251 |
23170 | TTLL12 | P32T-E | Human | Esophagus | ESCC | 1.19e-27 | 7.79e-01 | 0.1666 |
23170 | TTLL12 | P36T-E | Human | Esophagus | ESCC | 1.81e-07 | 3.46e-01 | 0.1187 |
23170 | TTLL12 | P37T-E | Human | Esophagus | ESCC | 1.88e-22 | 7.94e-01 | 0.1371 |
23170 | TTLL12 | P38T-E | Human | Esophagus | ESCC | 9.56e-11 | 2.55e-01 | 0.127 |
23170 | TTLL12 | P39T-E | Human | Esophagus | ESCC | 7.20e-14 | 3.15e-01 | 0.0894 |
23170 | TTLL12 | P40T-E | Human | Esophagus | ESCC | 5.36e-12 | 4.29e-01 | 0.109 |
23170 | TTLL12 | P42T-E | Human | Esophagus | ESCC | 2.26e-15 | 6.20e-01 | 0.1175 |
23170 | TTLL12 | P44T-E | Human | Esophagus | ESCC | 7.96e-07 | 2.03e-01 | 0.1096 |
23170 | TTLL12 | P47T-E | Human | Esophagus | ESCC | 1.45e-06 | 2.78e-01 | 0.1067 |
23170 | TTLL12 | P48T-E | Human | Esophagus | ESCC | 3.85e-18 | 3.72e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034340 | Colorectum | AD | response to type I interferon | 22/3918 | 58/18723 | 2.23e-03 | 1.75e-02 | 22 |
GO:0060337 | Colorectum | AD | type I interferon signaling pathway | 19/3918 | 50/18723 | 4.23e-03 | 2.91e-02 | 19 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0071357 | Colorectum | AD | cellular response to type I interferon | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00343401 | Colorectum | SER | response to type I interferon | 17/2897 | 58/18723 | 5.50e-03 | 4.07e-02 | 17 |
GO:00343402 | Colorectum | MSS | response to type I interferon | 20/3467 | 58/18723 | 2.82e-03 | 2.20e-02 | 20 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
GO:00603375 | Esophagus | ESCC | type I interferon signaling pathway | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:00713575 | Esophagus | ESCC | cellular response to type I interferon | 42/8552 | 52/18723 | 2.15e-07 | 3.30e-06 | 42 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
GO:00603385 | Esophagus | ESCC | regulation of type I interferon-mediated signaling pathway | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:00458245 | Esophagus | ESCC | negative regulation of innate immune response | 45/8552 | 71/18723 | 1.98e-03 | 8.90e-03 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTLL12 | deletion | Frame_Shift_Del | novel | c.1055delC | p.Pro352GlnfsTer5 | p.P352Qfs*5 | Q14166 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TTLL12 | SNV | Missense_Mutation | rs767983108 | c.754N>T | p.Arg252Trp | p.R252W | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TTLL12 | SNV | Missense_Mutation | rs759732112 | c.719N>A | p.Arg240Gln | p.R240Q | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TTLL12 | insertion | In_Frame_Ins | novel | c.1108_1109insCCA | p.Cys370delinsSerSer | p.C370delinsSS | Q14166 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
TTLL12 | SNV | Missense_Mutation | novel | c.430N>T | p.Arg144Cys | p.R144C | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TTLL12 | SNV | Missense_Mutation | novel | c.521A>G | p.Asn174Ser | p.N174S | Q14166 | protein_coding | tolerated(0.26) | benign(0.119) | TCGA-5M-AATA-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
TTLL12 | SNV | Missense_Mutation | rs745511521 | c.355C>T | p.Leu119Phe | p.L119F | Q14166 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | c.1411A>G | p.Ile471Val | p.I471V | Q14166 | protein_coding | tolerated(0.55) | benign(0.019) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTLL12 | SNV | Missense_Mutation | rs138428335 | c.1634C>T | p.Thr545Met | p.T545M | Q14166 | protein_coding | tolerated(0.06) | benign(0.108) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | rs148175933 | c.599N>A | p.Arg200Gln | p.R200Q | Q14166 | protein_coding | tolerated(0.19) | benign(0.158) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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