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Gene: TTC9C |
Gene summary for TTC9C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTC9C | Gene ID | 283237 |
| Gene name | tetratricopeptide repeat domain 9C | |
| Gene Alias | TTC9C | |
| Cytomap | 11q12.3 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N5M4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 283237 | TTC9C | P61T-E | Human | Esophagus | ESCC | 8.44e-08 | 2.11e-01 | 0.099 |
| 283237 | TTC9C | P62T-E | Human | Esophagus | ESCC | 5.90e-17 | 3.62e-01 | 0.1302 |
| 283237 | TTC9C | P65T-E | Human | Esophagus | ESCC | 9.61e-11 | 2.09e-01 | 0.0978 |
| 283237 | TTC9C | P74T-E | Human | Esophagus | ESCC | 9.54e-11 | 2.94e-01 | 0.1479 |
| 283237 | TTC9C | P75T-E | Human | Esophagus | ESCC | 3.39e-44 | 7.45e-01 | 0.1125 |
| 283237 | TTC9C | P76T-E | Human | Esophagus | ESCC | 2.50e-11 | 1.76e-01 | 0.1207 |
| 283237 | TTC9C | P79T-E | Human | Esophagus | ESCC | 2.47e-14 | 2.76e-01 | 0.1154 |
| 283237 | TTC9C | P80T-E | Human | Esophagus | ESCC | 4.46e-13 | 4.45e-01 | 0.155 |
| 283237 | TTC9C | P82T-E | Human | Esophagus | ESCC | 6.09e-12 | 5.20e-01 | 0.1072 |
| 283237 | TTC9C | P83T-E | Human | Esophagus | ESCC | 4.08e-11 | 4.47e-01 | 0.1738 |
| 283237 | TTC9C | P84T-E | Human | Esophagus | ESCC | 6.64e-03 | 2.62e-01 | 0.0933 |
| 283237 | TTC9C | P89T-E | Human | Esophagus | ESCC | 2.48e-16 | 8.63e-01 | 0.1752 |
| 283237 | TTC9C | P91T-E | Human | Esophagus | ESCC | 1.03e-11 | 9.98e-01 | 0.1828 |
| 283237 | TTC9C | P107T-E | Human | Esophagus | ESCC | 9.91e-19 | 3.97e-01 | 0.171 |
| 283237 | TTC9C | P126T-E | Human | Esophagus | ESCC | 1.01e-02 | 3.68e-01 | 0.1125 |
| 283237 | TTC9C | P127T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.11e-01 | 0.0826 |
| 283237 | TTC9C | P128T-E | Human | Esophagus | ESCC | 1.73e-21 | 6.73e-01 | 0.1241 |
| 283237 | TTC9C | P130T-E | Human | Esophagus | ESCC | 3.47e-30 | 5.31e-01 | 0.1676 |
| 283237 | TTC9C | C04 | Human | Oral cavity | OSCC | 6.44e-06 | 3.60e-01 | 0.2633 |
| 283237 | TTC9C | C21 | Human | Oral cavity | OSCC | 2.61e-14 | 5.10e-01 | 0.2678 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TTC9C | SNV | Missense_Mutation | c.451A>T | p.Thr151Ser | p.T151S | Q8N5M4 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| TTC9C | SNV | Missense_Mutation | novel | c.463N>T | p.Leu155Phe | p.L155F | Q8N5M4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A26W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
| TTC9C | SNV | Missense_Mutation | c.343N>A | p.Gly115Arg | p.G115R | Q8N5M4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15A-06 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
| TTC9C | SNV | Missense_Mutation | c.479N>C | p.Arg160Thr | p.R160T | Q8N5M4 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| TTC9C | SNV | Missense_Mutation | rs539570547 | c.275N>A | p.Arg92Gln | p.R92Q | Q8N5M4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| TTC9C | SNV | Missense_Mutation | rs757600351 | c.26N>G | p.Gln9Arg | p.Q9R | Q8N5M4 | protein_coding | tolerated(0.26) | benign(0) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TTC9C | SNV | Missense_Mutation | novel | c.493N>A | p.Leu165Ile | p.L165I | Q8N5M4 | protein_coding | tolerated(0.05) | benign(0.072) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TTC9C | SNV | Missense_Mutation | novel | c.401N>T | p.Ala134Val | p.A134V | Q8N5M4 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| TTC9C | SNV | Missense_Mutation | novel | c.260N>A | p.Pro87His | p.P87H | Q8N5M4 | protein_coding | tolerated(0.46) | benign(0.005) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TTC9C | SNV | Missense_Mutation | rs778887758 | c.271N>A | p.Glu91Lys | p.E91K | Q8N5M4 | protein_coding | deleterious(0.02) | possibly_damaging(0.46) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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