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Gene: TSTD1 |
Gene summary for TSTD1 |
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Gene information | Species | Human | Gene symbol | TSTD1 | Gene ID | 100131187 |
Gene name | thiosulfate sulfurtransferase like domain containing 1 | |
Gene Alias | KAT | |
Cytomap | 1q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q8NFU3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100131187 | TSTD1 | CCI_2 | Human | Cervix | CC | 5.82e-09 | -6.32e-01 | 0.5249 |
100131187 | TSTD1 | CCI_3 | Human | Cervix | CC | 3.80e-13 | -6.32e-01 | 0.516 |
100131187 | TSTD1 | CCII_1 | Human | Cervix | CC | 2.88e-18 | -6.32e-01 | 0.3249 |
100131187 | TSTD1 | L1 | Human | Cervix | CC | 2.93e-04 | -1.28e-01 | 0.0802 |
100131187 | TSTD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.10e-20 | 3.90e-01 | 0.0155 |
100131187 | TSTD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.83e-24 | 7.94e-01 | -0.1808 |
100131187 | TSTD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-08 | 5.85e-01 | 0.0216 |
100131187 | TSTD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.44e-34 | 9.11e-01 | -0.0811 |
100131187 | TSTD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.63e-17 | 4.36e-01 | -0.1088 |
100131187 | TSTD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.26e-35 | 6.15e-01 | -0.1954 |
100131187 | TSTD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.42e-18 | 1.15e+00 | -0.2602 |
100131187 | TSTD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.23e-14 | 9.42e-01 | -0.2196 |
100131187 | TSTD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-22 | 6.56e-01 | -0.1207 |
100131187 | TSTD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.54e-17 | 5.10e-01 | -0.1526 |
100131187 | TSTD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.75e-49 | 8.29e-01 | -0.1464 |
100131187 | TSTD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.56e-26 | 4.95e-01 | -0.1001 |
100131187 | TSTD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.48e-30 | 7.33e-01 | -0.059 |
100131187 | TSTD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.79e-16 | 6.78e-01 | -0.1706 |
100131187 | TSTD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.61e-16 | 8.22e-01 | -0.2061 |
100131187 | TSTD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.79e-07 | 4.90e-01 | -0.1462 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:000679012 | Oral cavity | LP | sulfur compound metabolic process | 106/4623 | 339/18723 | 3.36e-03 | 2.25e-02 | 106 |
GO:00067903 | Stomach | GC | sulfur compound metabolic process | 35/1159 | 339/18723 | 2.10e-03 | 2.10e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSTD1 | insertion | In_Frame_Ins | novel | c.150_151insAGAGAC | p.Ser50_Ala51insArgAsp | p.S50_A51insRD | Q8NFU3 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
TSTD1 | insertion | Frame_Shift_Ins | novel | c.148_149insATTTTTTGTATTTTTTTTTA | p.Ser50AsnfsTer80 | p.S50Nfs*80 | Q8NFU3 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
TSTD1 | SNV | Missense_Mutation | c.310G>A | p.Ala104Thr | p.A104T | Q8NFU3 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TSTD1 | SNV | Missense_Mutation | c.197A>G | p.Glu66Gly | p.E66G | Q8NFU3 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TSTD1 | SNV | Missense_Mutation | novel | c.314N>T | p.Gly105Val | p.G105V | Q8NFU3 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
TSTD1 | SNV | Missense_Mutation | novel | c.130C>T | p.Pro44Ser | p.P44S | Q8NFU3 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-G3-AAV7-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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