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Gene: TRIM23 |
Gene summary for TRIM23 |
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Gene information | Species | Human | Gene symbol | TRIM23 | Gene ID | 373 |
Gene name | tripartite motif containing 23 | |
Gene Alias | ARD1 | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P36406 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
373 | TRIM23 | PTC01 | Human | Thyroid | PTC | 4.94e-07 | 2.65e-02 | 0.1899 |
373 | TRIM23 | PTC03 | Human | Thyroid | PTC | 4.53e-03 | 1.57e-01 | 0.1784 |
373 | TRIM23 | PTC04 | Human | Thyroid | PTC | 6.72e-07 | 1.27e-01 | 0.1927 |
373 | TRIM23 | PTC05 | Human | Thyroid | PTC | 3.75e-08 | 4.36e-01 | 0.2065 |
373 | TRIM23 | PTC06 | Human | Thyroid | PTC | 2.14e-20 | 4.21e-01 | 0.2057 |
373 | TRIM23 | PTC07 | Human | Thyroid | PTC | 3.27e-22 | 3.44e-01 | 0.2044 |
373 | TRIM23 | ATC09 | Human | Thyroid | ATC | 2.76e-03 | 1.03e-01 | 0.2871 |
373 | TRIM23 | ATC12 | Human | Thyroid | ATC | 4.66e-12 | 1.09e-01 | 0.34 |
373 | TRIM23 | ATC13 | Human | Thyroid | ATC | 1.96e-22 | 3.00e-01 | 0.34 |
373 | TRIM23 | ATC1 | Human | Thyroid | ATC | 8.90e-05 | 1.47e-01 | 0.2878 |
373 | TRIM23 | ATC2 | Human | Thyroid | ATC | 2.50e-12 | 7.55e-01 | 0.34 |
373 | TRIM23 | ATC3 | Human | Thyroid | ATC | 3.39e-02 | 1.41e-01 | 0.338 |
373 | TRIM23 | ATC4 | Human | Thyroid | ATC | 4.88e-13 | 1.40e-01 | 0.34 |
373 | TRIM23 | ATC5 | Human | Thyroid | ATC | 4.71e-18 | 3.17e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM23 | SNV | Missense_Mutation | c.959N>T | p.Trp320Leu | p.W320L | P36406 | protein_coding | tolerated(0.68) | benign(0) | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |
TRIM23 | SNV | Missense_Mutation | rs371065655 | c.1646N>A | p.Arg549Gln | p.R549Q | P36406 | protein_coding | tolerated(0.74) | possibly_damaging(0.833) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | c.232N>C | p.Val78Leu | p.V78L | P36406 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM23 | SNV | Missense_Mutation | c.640N>G | p.His214Asp | p.H214D | P36406 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
TRIM23 | SNV | Missense_Mutation | c.1417C>G | p.Gln473Glu | p.Q473E | P36406 | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
TRIM23 | SNV | Missense_Mutation | c.1516N>T | p.Ala506Ser | p.A506S | P36406 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
TRIM23 | SNV | Missense_Mutation | c.1516N>T | p.Ala506Ser | p.A506S | P36406 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM23 | SNV | Missense_Mutation | c.268N>G | p.Lys90Glu | p.K90E | P36406 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM23 | SNV | Missense_Mutation | c.275N>T | p.Asn92Ile | p.N92I | P36406 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TRIM23 | SNV | Missense_Mutation | rs752496483 | c.866G>A | p.Arg289Gln | p.R289Q | P36406 | protein_coding | tolerated(0.07) | benign(0.246) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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