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Gene: TOMM22 |
Gene summary for TOMM22 |
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Gene information | Species | Human | Gene symbol | TOMM22 | Gene ID | 56993 |
Gene name | translocase of outer mitochondrial membrane 22 | |
Gene Alias | 1C9-2 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | Q549C5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56993 | TOMM22 | EEC-subject1 | Human | Endometrium | EEC | 2.29e-11 | -3.65e-01 | -0.2682 |
56993 | TOMM22 | EEC-subject2 | Human | Endometrium | EEC | 1.04e-17 | -4.36e-01 | -0.2607 |
56993 | TOMM22 | EEC-subject3 | Human | Endometrium | EEC | 2.32e-38 | -4.49e-01 | -0.2525 |
56993 | TOMM22 | EEC-subject4 | Human | Endometrium | EEC | 1.76e-06 | -3.22e-01 | -0.2571 |
56993 | TOMM22 | EEC-subject5 | Human | Endometrium | EEC | 5.66e-07 | -2.99e-01 | -0.249 |
56993 | TOMM22 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.75e-22 | -2.46e-01 | -0.1869 |
56993 | TOMM22 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 7.56e-20 | -2.68e-01 | -0.1875 |
56993 | TOMM22 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.41e-26 | -2.65e-01 | -0.1883 |
56993 | TOMM22 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 8.82e-26 | -1.83e-01 | -0.1934 |
56993 | TOMM22 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.73e-43 | -2.31e-01 | -0.1917 |
56993 | TOMM22 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.39e-30 | -1.89e-01 | -0.1916 |
56993 | TOMM22 | LZE2T | Human | Esophagus | ESCC | 1.12e-04 | 8.78e-01 | 0.082 |
56993 | TOMM22 | LZE4T | Human | Esophagus | ESCC | 1.74e-18 | 6.80e-01 | 0.0811 |
56993 | TOMM22 | LZE7T | Human | Esophagus | ESCC | 7.06e-13 | 1.18e+00 | 0.0667 |
56993 | TOMM22 | LZE8T | Human | Esophagus | ESCC | 1.19e-16 | 8.81e-01 | 0.067 |
56993 | TOMM22 | LZE20T | Human | Esophagus | ESCC | 4.97e-04 | 2.95e-01 | 0.0662 |
56993 | TOMM22 | LZE22T | Human | Esophagus | ESCC | 2.89e-06 | 7.85e-01 | 0.068 |
56993 | TOMM22 | LZE24T | Human | Esophagus | ESCC | 2.77e-31 | 1.18e+00 | 0.0596 |
56993 | TOMM22 | LZE21T | Human | Esophagus | ESCC | 9.20e-07 | 9.63e-01 | 0.0655 |
56993 | TOMM22 | LZE6T | Human | Esophagus | ESCC | 9.31e-10 | 7.48e-01 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0090151 | Colorectum | AD | establishment of protein localization to mitochondrial membrane | 15/3918 | 30/18723 | 3.85e-04 | 4.39e-03 | 15 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0051204 | Colorectum | AD | protein insertion into mitochondrial membrane | 12/3918 | 25/18723 | 2.30e-03 | 1.80e-02 | 12 |
GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00705851 | Colorectum | SER | protein localization to mitochondrion | 42/2897 | 125/18723 | 3.75e-07 | 1.98e-05 | 42 |
GO:00070061 | Colorectum | SER | mitochondrial membrane organization | 38/2897 | 116/18723 | 2.66e-06 | 1.10e-04 | 38 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00726551 | Colorectum | SER | establishment of protein localization to mitochondrion | 38/2897 | 120/18723 | 6.60e-06 | 2.33e-04 | 38 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOMM22 | SNV | Missense_Mutation | c.365G>A | p.Gly122Glu | p.G122E | Q9NS69 | protein_coding | deleterious(0.04) | probably_damaging(0.953) | TCGA-AN-A0FV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TOMM22 | SNV | Missense_Mutation | c.202N>C | p.Asp68His | p.D68H | Q9NS69 | protein_coding | deleterious(0.03) | benign(0.054) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOMM22 | SNV | Missense_Mutation | c.128C>T | p.Thr43Ile | p.T43I | Q9NS69 | protein_coding | deleterious(0.04) | possibly_damaging(0.46) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TOMM22 | SNV | Missense_Mutation | novel | c.152N>C | p.Leu51Pro | p.L51P | Q9NS69 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TOMM22 | SNV | Missense_Mutation | rs757015391 | c.193N>A | p.Ala65Thr | p.A65T | Q9NS69 | protein_coding | tolerated(0.24) | benign(0.022) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOMM22 | SNV | Missense_Mutation | c.138G>T | p.Glu46Asp | p.E46D | Q9NS69 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOMM22 | SNV | Missense_Mutation | novel | c.221C>T | p.Ala74Val | p.A74V | Q9NS69 | protein_coding | tolerated(0.87) | benign(0.018) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TOMM22 | SNV | Missense_Mutation | novel | c.152N>C | p.Leu51Pro | p.L51P | Q9NS69 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TOMM22 | SNV | Missense_Mutation | novel | c.67N>T | p.Gly23Cys | p.G23C | Q9NS69 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TOMM22 | SNV | Missense_Mutation | c.225N>T | p.Gln75His | p.Q75H | Q9NS69 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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