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Gene: TOMM20 |
Gene summary for TOMM20 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TOMM20 | Gene ID | 9804 |
Gene name | translocase of outer mitochondrial membrane 20 | |
Gene Alias | MAS20 | |
Cytomap | 1q42.3 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | A0A024R3W2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9804 | TOMM20 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.59e-03 | 4.46e-01 | -0.0179 |
9804 | TOMM20 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.41e-08 | 5.03e-01 | 0.096 |
9804 | TOMM20 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.94e-03 | 5.42e-01 | 0.0446 |
9804 | TOMM20 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.80e-02 | 3.43e-01 | 0.0338 |
9804 | TOMM20 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.13e-07 | 5.03e-01 | 0.0674 |
9804 | TOMM20 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.18e-05 | 8.05e-01 | -0.0124 |
9804 | TOMM20 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.27e-04 | 4.54e-01 | 0.0588 |
9804 | TOMM20 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.74e-27 | 1.01e+00 | 0.294 |
9804 | TOMM20 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.42e-06 | 1.29e+00 | 0.3487 |
9804 | TOMM20 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.31e-12 | 7.47e-01 | 0.281 |
9804 | TOMM20 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.44e-31 | 1.12e+00 | 0.3859 |
9804 | TOMM20 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.86e-03 | 3.51e-01 | 0.3005 |
9804 | TOMM20 | A015-C-203 | Human | Colorectum | FAP | 8.97e-03 | -5.00e-02 | -0.1294 |
9804 | TOMM20 | A002-C-201 | Human | Colorectum | FAP | 2.44e-02 | -7.40e-02 | 0.0324 |
9804 | TOMM20 | A002-C-205 | Human | Colorectum | FAP | 8.99e-04 | -2.08e-02 | -0.1236 |
9804 | TOMM20 | A015-C-006 | Human | Colorectum | FAP | 4.63e-02 | -8.88e-02 | -0.0994 |
9804 | TOMM20 | A002-C-114 | Human | Colorectum | FAP | 9.32e-03 | -1.13e-01 | -0.1561 |
9804 | TOMM20 | A015-C-104 | Human | Colorectum | FAP | 4.77e-05 | -1.38e-01 | -0.1899 |
9804 | TOMM20 | A002-C-116 | Human | Colorectum | FAP | 2.93e-04 | 6.63e-02 | -0.0452 |
9804 | TOMM20 | A014-C-008 | Human | Colorectum | FAP | 4.19e-02 | -1.51e-01 | -0.191 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:199054214 | Breast | IDC | mitochondrial transmembrane transport | 25/1434 | 102/18723 | 1.39e-07 | 7.74e-06 | 25 |
GO:007058513 | Breast | IDC | protein localization to mitochondrion | 23/1434 | 125/18723 | 6.92e-05 | 1.40e-03 | 23 |
GO:007265513 | Breast | IDC | establishment of protein localization to mitochondrion | 22/1434 | 120/18723 | 1.04e-04 | 1.97e-03 | 22 |
GO:000660514 | Breast | IDC | protein targeting | 43/1434 | 314/18723 | 1.44e-04 | 2.53e-03 | 43 |
GO:007259413 | Breast | IDC | establishment of protein localization to organelle | 51/1434 | 422/18723 | 7.94e-04 | 9.55e-03 | 51 |
GO:000662613 | Breast | IDC | protein targeting to mitochondrion | 17/1434 | 100/18723 | 1.47e-03 | 1.50e-02 | 17 |
GO:007180612 | Breast | IDC | protein transmembrane transport | 12/1434 | 59/18723 | 1.49e-03 | 1.50e-02 | 12 |
GO:000640313 | Breast | IDC | RNA localization | 27/1434 | 201/18723 | 3.04e-03 | 2.60e-02 | 27 |
GO:000110112 | Breast | IDC | response to acid chemical | 20/1434 | 135/18723 | 3.28e-03 | 2.75e-02 | 20 |
GO:00432003 | Breast | IDC | response to amino acid | 17/1434 | 116/18723 | 7.13e-03 | 4.92e-02 | 17 |
GO:000683923 | Breast | DCIS | mitochondrial transport | 51/1390 | 254/18723 | 5.04e-11 | 6.79e-09 | 51 |
GO:199054222 | Breast | DCIS | mitochondrial transmembrane transport | 25/1390 | 102/18723 | 7.63e-08 | 4.45e-06 | 25 |
GO:007058522 | Breast | DCIS | protein localization to mitochondrion | 23/1390 | 125/18723 | 4.28e-05 | 9.05e-04 | 23 |
GO:007265522 | Breast | DCIS | establishment of protein localization to mitochondrion | 22/1390 | 120/18723 | 6.60e-05 | 1.31e-03 | 22 |
GO:000660523 | Breast | DCIS | protein targeting | 43/1390 | 314/18723 | 7.17e-05 | 1.41e-03 | 43 |
GO:007259423 | Breast | DCIS | establishment of protein localization to organelle | 51/1390 | 422/18723 | 3.91e-04 | 5.40e-03 | 51 |
GO:000662622 | Breast | DCIS | protein targeting to mitochondrion | 17/1390 | 100/18723 | 1.05e-03 | 1.15e-02 | 17 |
GO:007180621 | Breast | DCIS | protein transmembrane transport | 12/1390 | 59/18723 | 1.14e-03 | 1.22e-02 | 12 |
GO:000640322 | Breast | DCIS | RNA localization | 27/1390 | 201/18723 | 1.97e-03 | 1.84e-02 | 27 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOMM20 | SNV | Missense_Mutation | novel | c.102N>A | p.Phe34Leu | p.F34L | Q15388 | protein_coding | tolerated(0.06) | benign(0.086) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOMM20 | SNV | Missense_Mutation | novel | c.299N>T | p.Cys100Phe | p.C100F | Q15388 | protein_coding | deleterious(0.01) | possibly_damaging(0.646) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOMM20 | SNV | Missense_Mutation | novel | c.86N>A | p.Arg29Gln | p.R29Q | Q15388 | protein_coding | tolerated(0.08) | benign(0.148) | TCGA-D6-A6EN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TOMM20 | SNV | Missense_Mutation | c.28N>A | p.Ala10Thr | p.A10T | Q15388 | protein_coding | deleterious(0.03) | possibly_damaging(0.836) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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