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Gene: TNS1 |
Gene summary for TNS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TNS1 | Gene ID | 7145 |
Gene name | tensin 1 | |
Gene Alias | MST091 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z6H8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7145 | TNS1 | ATC3 | Human | Thyroid | ATC | 1.25e-02 | 6.23e-01 | 0.338 |
7145 | TNS1 | ATC4 | Human | Thyroid | ATC | 4.73e-21 | 6.05e-01 | 0.34 |
7145 | TNS1 | ATC5 | Human | Thyroid | ATC | 8.65e-20 | 4.83e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNS1 | SNV | Missense_Mutation | c.2866A>T | p.Met956Leu | p.M956L | Q9HBL0 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
TNS1 | SNV | Missense_Mutation | c.5195G>T | p.Gly1732Val | p.G1732V | Q9HBL0 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TNS1 | SNV | Missense_Mutation | c.1648A>G | p.Met550Val | p.M550V | Q9HBL0 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TNS1 | SNV | Missense_Mutation | c.4143N>A | p.Ser1381Arg | p.S1381R | Q9HBL0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
TNS1 | SNV | Missense_Mutation | c.3221N>A | p.Ser1074Asn | p.S1074N | Q9HBL0 | protein_coding | tolerated(0.12) | possibly_damaging(0.763) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
TNS1 | SNV | Missense_Mutation | rs762213864 | c.3092G>A | p.Arg1031Gln | p.R1031Q | Q9HBL0 | protein_coding | tolerated(0.09) | benign(0.233) | TCGA-S3-A6ZG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
TNS1 | insertion | In_Frame_Ins | novel | c.4185_4186insAAG | p.Gly1395_Asp1396insLys | p.G1395_D1396insK | Q9HBL0 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TNS1 | insertion | Frame_Shift_Ins | novel | c.4183_4184insAATCATCATCGAATGGAAAT | p.Gly1395GlufsTer66 | p.G1395Efs*66 | Q9HBL0 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TNS1 | insertion | Nonsense_Mutation | novel | c.2586_2587insTTTTCCTGTTAGTCTTTGCTGAGGACCAGCCCTGTAT | p.Glu863PhefsTer4 | p.E863Ffs*4 | Q9HBL0 | protein_coding | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
TNS1 | insertion | Frame_Shift_Ins | novel | c.355_356insTAAGTGGTAGACCTGAGCTG | p.Arg119IlefsTer9 | p.R119Ifs*9 | Q9HBL0 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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