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Gene: TMEM79 |
Gene summary for TMEM79 |
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Gene information | Species | Human | Gene symbol | TMEM79 | Gene ID | 84283 |
Gene name | transmembrane protein 79 | |
Gene Alias | MATT | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q9BSE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84283 | TMEM79 | P79T-E | Human | Esophagus | ESCC | 2.06e-03 | 1.15e-01 | 0.1154 |
84283 | TMEM79 | P82T-E | Human | Esophagus | ESCC | 5.16e-06 | 4.68e-01 | 0.1072 |
84283 | TMEM79 | P83T-E | Human | Esophagus | ESCC | 3.12e-09 | 3.70e-01 | 0.1738 |
84283 | TMEM79 | P84T-E | Human | Esophagus | ESCC | 1.67e-09 | 5.21e-01 | 0.0933 |
84283 | TMEM79 | P89T-E | Human | Esophagus | ESCC | 2.15e-12 | 9.36e-01 | 0.1752 |
84283 | TMEM79 | P91T-E | Human | Esophagus | ESCC | 1.73e-19 | 1.92e+00 | 0.1828 |
84283 | TMEM79 | P107T-E | Human | Esophagus | ESCC | 1.37e-08 | 1.17e-01 | 0.171 |
84283 | TMEM79 | P127T-E | Human | Esophagus | ESCC | 1.64e-08 | 1.64e-01 | 0.0826 |
84283 | TMEM79 | P128T-E | Human | Esophagus | ESCC | 4.99e-10 | 2.68e-01 | 0.1241 |
84283 | TMEM79 | P130T-E | Human | Esophagus | ESCC | 7.27e-33 | 6.55e-01 | 0.1676 |
84283 | TMEM79 | C04 | Human | Oral cavity | OSCC | 2.56e-12 | 6.07e-01 | 0.2633 |
84283 | TMEM79 | C21 | Human | Oral cavity | OSCC | 6.49e-24 | 9.76e-01 | 0.2678 |
84283 | TMEM79 | C30 | Human | Oral cavity | OSCC | 3.39e-47 | 2.03e+00 | 0.3055 |
84283 | TMEM79 | C38 | Human | Oral cavity | OSCC | 1.09e-04 | 7.60e-01 | 0.172 |
84283 | TMEM79 | C43 | Human | Oral cavity | OSCC | 1.01e-12 | 4.22e-01 | 0.1704 |
84283 | TMEM79 | C46 | Human | Oral cavity | OSCC | 1.91e-14 | 4.19e-01 | 0.1673 |
84283 | TMEM79 | C51 | Human | Oral cavity | OSCC | 7.54e-20 | 1.10e+00 | 0.2674 |
84283 | TMEM79 | C57 | Human | Oral cavity | OSCC | 2.00e-17 | 6.69e-01 | 0.1679 |
84283 | TMEM79 | C06 | Human | Oral cavity | OSCC | 7.00e-08 | 1.16e+00 | 0.2699 |
84283 | TMEM79 | LN22 | Human | Oral cavity | OSCC | 4.25e-07 | 7.86e-01 | 0.1733 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
GO:00456826 | Esophagus | ESCC | regulation of epidermis development | 46/8552 | 65/18723 | 3.65e-05 | 2.97e-04 | 46 |
GO:00302167 | Esophagus | ESCC | keratinocyte differentiation | 86/8552 | 139/18723 | 8.53e-05 | 6.19e-04 | 86 |
GO:00224043 | Esophagus | ESCC | molting cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
GO:00224053 | Esophagus | ESCC | hair cycle process | 53/8552 | 84/18723 | 9.62e-04 | 4.88e-03 | 53 |
GO:0001942 | Esophagus | ESCC | hair follicle development | 51/8552 | 81/18723 | 1.27e-03 | 6.14e-03 | 51 |
GO:0098773 | Esophagus | ESCC | skin epidermis development | 53/8552 | 85/18723 | 1.43e-03 | 6.77e-03 | 53 |
GO:00423033 | Esophagus | ESCC | molting cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
GO:00426333 | Esophagus | ESCC | hair cycle | 64/8552 | 107/18723 | 2.24e-03 | 9.85e-03 | 64 |
GO:00456841 | Esophagus | ESCC | positive regulation of epidermis development | 23/8552 | 32/18723 | 2.43e-03 | 1.06e-02 | 23 |
GO:00435887 | Oral cavity | OSCC | skin development | 143/7305 | 263/18723 | 2.77e-07 | 4.27e-06 | 143 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00302166 | Oral cavity | OSCC | keratinocyte differentiation | 81/7305 | 139/18723 | 3.16e-06 | 3.81e-05 | 81 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:000206419 | Oral cavity | OSCC | epithelial cell development | 116/7305 | 220/18723 | 2.34e-05 | 2.21e-04 | 116 |
GO:00456825 | Oral cavity | OSCC | regulation of epidermis development | 41/7305 | 65/18723 | 7.29e-05 | 5.73e-04 | 41 |
GO:005087819 | Oral cavity | OSCC | regulation of body fluid levels | 179/7305 | 379/18723 | 6.19e-04 | 3.50e-03 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM79 | SNV | Missense_Mutation | c.896N>T | p.Ala299Val | p.A299V | Q9BSE2 | protein_coding | tolerated(0.11) | possibly_damaging(0.781) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM79 | SNV | Missense_Mutation | c.178G>C | p.Glu60Gln | p.E60Q | Q9BSE2 | protein_coding | tolerated(0.08) | benign(0.361) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM79 | SNV | Missense_Mutation | rs762068186 | c.658N>A | p.Ala220Thr | p.A220T | Q9BSE2 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-Z7-A8R5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
TMEM79 | SNV | Missense_Mutation | novel | c.1021N>A | p.Gly341Ser | p.G341S | Q9BSE2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | rs748534614 | c.890N>G | p.Asn297Ser | p.N297S | Q9BSE2 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | c.979N>C | p.Tyr327His | p.Y327H | Q9BSE2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM79 | SNV | Missense_Mutation | c.172G>T | p.Ala58Ser | p.A58S | Q9BSE2 | protein_coding | tolerated(0.05) | benign(0.168) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM79 | SNV | Missense_Mutation | novel | c.891C>G | p.Asn297Lys | p.N297K | Q9BSE2 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM79 | SNV | Missense_Mutation | rs750729853 | c.610G>A | p.Val204Met | p.V204M | Q9BSE2 | protein_coding | tolerated(0.41) | benign(0.024) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
TMEM79 | SNV | Missense_Mutation | rs151038552 | c.343G>A | p.Glu115Lys | p.E115K | Q9BSE2 | protein_coding | tolerated(0.16) | benign(0.015) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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