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Gene: TMEM70 |
Gene summary for TMEM70 |
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Gene information | Species | Human | Gene symbol | TMEM70 | Gene ID | 54968 |
Gene name | transmembrane protein 70 | |
Gene Alias | MC5DN2 | |
Cytomap | 8q21.11 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9BUB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54968 | TMEM70 | P52T-E | Human | Esophagus | ESCC | 5.65e-14 | 4.48e-01 | 0.1555 |
54968 | TMEM70 | P54T-E | Human | Esophagus | ESCC | 3.49e-19 | 7.37e-01 | 0.0975 |
54968 | TMEM70 | P56T-E | Human | Esophagus | ESCC | 1.71e-04 | 6.21e-01 | 0.1613 |
54968 | TMEM70 | P57T-E | Human | Esophagus | ESCC | 2.20e-05 | 2.45e-01 | 0.0926 |
54968 | TMEM70 | P61T-E | Human | Esophagus | ESCC | 7.06e-04 | 1.68e-01 | 0.099 |
54968 | TMEM70 | P62T-E | Human | Esophagus | ESCC | 1.64e-38 | 7.59e-01 | 0.1302 |
54968 | TMEM70 | P65T-E | Human | Esophagus | ESCC | 3.11e-19 | 5.54e-01 | 0.0978 |
54968 | TMEM70 | P74T-E | Human | Esophagus | ESCC | 4.11e-45 | 1.14e+00 | 0.1479 |
54968 | TMEM70 | P75T-E | Human | Esophagus | ESCC | 5.51e-61 | 1.27e+00 | 0.1125 |
54968 | TMEM70 | P76T-E | Human | Esophagus | ESCC | 6.16e-16 | 1.37e-01 | 0.1207 |
54968 | TMEM70 | P79T-E | Human | Esophagus | ESCC | 3.96e-37 | 1.10e+00 | 0.1154 |
54968 | TMEM70 | P80T-E | Human | Esophagus | ESCC | 6.96e-36 | 1.30e+00 | 0.155 |
54968 | TMEM70 | P82T-E | Human | Esophagus | ESCC | 8.46e-05 | 4.97e-01 | 0.1072 |
54968 | TMEM70 | P83T-E | Human | Esophagus | ESCC | 2.36e-21 | 7.06e-01 | 0.1738 |
54968 | TMEM70 | P84T-E | Human | Esophagus | ESCC | 1.14e-09 | 4.79e-01 | 0.0933 |
54968 | TMEM70 | P89T-E | Human | Esophagus | ESCC | 5.23e-12 | 1.24e+00 | 0.1752 |
54968 | TMEM70 | P91T-E | Human | Esophagus | ESCC | 3.32e-13 | 1.60e+00 | 0.1828 |
54968 | TMEM70 | P107T-E | Human | Esophagus | ESCC | 2.33e-25 | 7.54e-01 | 0.171 |
54968 | TMEM70 | P126T-E | Human | Esophagus | ESCC | 3.17e-02 | 2.16e-01 | 0.1125 |
54968 | TMEM70 | P127T-E | Human | Esophagus | ESCC | 2.73e-12 | 1.09e-02 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00700711 | Esophagus | ESCC | proton-transporting two-sector ATPase complex assembly | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
GO:0070071 | Liver | HCC | proton-transporting two-sector ATPase complex assembly | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
GO:00700712 | Thyroid | PTC | proton-transporting two-sector ATPase complex assembly | 11/5968 | 15/18723 | 1.19e-03 | 6.84e-03 | 11 |
GO:007007111 | Thyroid | ATC | proton-transporting two-sector ATPase complex assembly | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM70 | SNV | Missense_Mutation | c.596N>G | p.Asp199Gly | p.D199G | Q9BUB7 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A8-A075-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | CR | |
TMEM70 | SNV | Missense_Mutation | novel | c.349A>G | p.Ile117Val | p.I117V | Q9BUB7 | protein_coding | tolerated(0.19) | benign(0.033) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
TMEM70 | SNV | Missense_Mutation | novel | c.415C>A | p.Pro139Thr | p.P139T | Q9BUB7 | protein_coding | tolerated(0.14) | benign(0.355) | TCGA-EW-A2FR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | SD |
TMEM70 | SNV | Missense_Mutation | c.763N>T | p.Arg255Trp | p.R255W | Q9BUB7 | protein_coding | deleterious(0.01) | benign(0.153) | TCGA-EA-A44S-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
TMEM70 | SNV | Missense_Mutation | novel | c.536A>T | p.Tyr179Phe | p.Y179F | Q9BUB7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM70 | SNV | Missense_Mutation | novel | c.574A>C | p.Ser192Arg | p.S192R | Q9BUB7 | protein_coding | tolerated(0.44) | benign(0.012) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM70 | SNV | Missense_Mutation | novel | c.700N>A | p.His234Asn | p.H234N | Q9BUB7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TMEM70 | SNV | Missense_Mutation | novel | c.724G>A | p.Glu242Lys | p.E242K | Q9BUB7 | protein_coding | deleterious(0.02) | benign(0.104) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM70 | SNV | Missense_Mutation | novel | c.710G>A | p.Gly237Asp | p.G237D | Q9BUB7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM70 | SNV | Missense_Mutation | novel | c.37G>A | p.Glu13Lys | p.E13K | Q9BUB7 | protein_coding | tolerated_low_confidence(0.12) | benign(0.028) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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