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Gene: TMEM63A |
Gene summary for TMEM63A |
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Gene information | Species | Human | Gene symbol | TMEM63A | Gene ID | 9725 |
Gene name | transmembrane protein 63A | |
Gene Alias | HLD19 | |
Cytomap | 1q42.12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R3T3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9725 | TMEM63A | P10T-E | Human | Esophagus | ESCC | 5.12e-08 | 2.74e-02 | 0.116 |
9725 | TMEM63A | P11T-E | Human | Esophagus | ESCC | 1.59e-04 | 1.91e-01 | 0.1426 |
9725 | TMEM63A | P12T-E | Human | Esophagus | ESCC | 6.96e-10 | -2.12e-03 | 0.1122 |
9725 | TMEM63A | P15T-E | Human | Esophagus | ESCC | 4.82e-08 | 8.62e-02 | 0.1149 |
9725 | TMEM63A | P16T-E | Human | Esophagus | ESCC | 3.98e-21 | 2.77e-01 | 0.1153 |
9725 | TMEM63A | P20T-E | Human | Esophagus | ESCC | 5.26e-04 | 4.00e-03 | 0.1124 |
9725 | TMEM63A | P21T-E | Human | Esophagus | ESCC | 1.27e-13 | 1.62e-01 | 0.1617 |
9725 | TMEM63A | P22T-E | Human | Esophagus | ESCC | 2.92e-17 | 1.36e-01 | 0.1236 |
9725 | TMEM63A | P23T-E | Human | Esophagus | ESCC | 9.68e-11 | 9.73e-02 | 0.108 |
9725 | TMEM63A | P24T-E | Human | Esophagus | ESCC | 8.26e-06 | 1.93e-02 | 0.1287 |
9725 | TMEM63A | P26T-E | Human | Esophagus | ESCC | 1.10e-07 | 1.59e-02 | 0.1276 |
9725 | TMEM63A | P27T-E | Human | Esophagus | ESCC | 2.65e-05 | 2.96e-02 | 0.1055 |
9725 | TMEM63A | P28T-E | Human | Esophagus | ESCC | 1.22e-16 | 8.44e-02 | 0.1149 |
9725 | TMEM63A | P30T-E | Human | Esophagus | ESCC | 1.01e-09 | 3.21e-01 | 0.137 |
9725 | TMEM63A | P31T-E | Human | Esophagus | ESCC | 1.75e-26 | 1.52e-01 | 0.1251 |
9725 | TMEM63A | P32T-E | Human | Esophagus | ESCC | 6.08e-06 | -3.77e-02 | 0.1666 |
9725 | TMEM63A | P37T-E | Human | Esophagus | ESCC | 1.03e-04 | 6.73e-02 | 0.1371 |
9725 | TMEM63A | P39T-E | Human | Esophagus | ESCC | 2.11e-07 | 3.51e-02 | 0.0894 |
9725 | TMEM63A | P40T-E | Human | Esophagus | ESCC | 3.66e-05 | 9.57e-02 | 0.109 |
9725 | TMEM63A | P47T-E | Human | Esophagus | ESCC | 4.14e-06 | 3.04e-02 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM63A | SNV | Missense_Mutation | novel | c.1096G>T | p.Asp366Tyr | p.D366Y | O94886 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs376648031 | c.2086G>A | p.Ala696Thr | p.A696T | O94886 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs760750326 | c.1751N>A | p.Arg584His | p.R584H | O94886 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
TMEM63A | insertion | Nonsense_Mutation | novel | c.975_976insTCTGAGAGAATAATTGTTCCCTCTGAGCTCTTGGGGACCTAAG | p.Arg326SerfsTer14 | p.R326Sfs*14 | O94886 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
TMEM63A | insertion | Frame_Shift_Ins | novel | c.790_791insGCAA | p.Tyr264CysfsTer18 | p.Y264Cfs*18 | O94886 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM63A | insertion | In_Frame_Ins | novel | c.789_790insAAGTGTCAGAGCCTTCAG | p.Cys263_Tyr264insLysCysGlnSerLeuGln | p.C263_Y264insKCQSLQ | O94886 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM63A | deletion | Frame_Shift_Del | c.505delG | p.Asp169ThrfsTer15 | p.D169Tfs*15 | O94886 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
TMEM63A | SNV | Missense_Mutation | novel | c.1523T>C | p.Ile508Thr | p.I508T | O94886 | protein_coding | tolerated(0.47) | benign(0.124) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM63A | SNV | Missense_Mutation | novel | c.2362C>A | p.Pro788Thr | p.P788T | O94886 | protein_coding | tolerated(0.53) | benign(0.025) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM63A | SNV | Missense_Mutation | rs753026260 | c.1474C>T | p.His492Tyr | p.H492Y | O94886 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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