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Gene: TMEM57 |
Gene summary for TMEM57 |
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Gene information | Species | Human | Gene symbol | TMEM57 | Gene ID | 55219 |
Gene name | macoilin 1 | |
Gene Alias | MACOILIN | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0006935 | UniProtAcc | Q8N5G2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55219 | TMEM57 | P52T-E | Human | Esophagus | ESCC | 7.42e-17 | 3.97e-01 | 0.1555 |
55219 | TMEM57 | P54T-E | Human | Esophagus | ESCC | 9.87e-16 | 2.26e-01 | 0.0975 |
55219 | TMEM57 | P56T-E | Human | Esophagus | ESCC | 5.72e-11 | 8.63e-01 | 0.1613 |
55219 | TMEM57 | P57T-E | Human | Esophagus | ESCC | 1.54e-26 | 4.29e-01 | 0.0926 |
55219 | TMEM57 | P61T-E | Human | Esophagus | ESCC | 1.02e-15 | 2.52e-01 | 0.099 |
55219 | TMEM57 | P62T-E | Human | Esophagus | ESCC | 2.53e-45 | 6.93e-01 | 0.1302 |
55219 | TMEM57 | P65T-E | Human | Esophagus | ESCC | 3.12e-21 | 3.77e-01 | 0.0978 |
55219 | TMEM57 | P74T-E | Human | Esophagus | ESCC | 8.17e-17 | 4.21e-01 | 0.1479 |
55219 | TMEM57 | P75T-E | Human | Esophagus | ESCC | 9.91e-27 | 4.90e-01 | 0.1125 |
55219 | TMEM57 | P76T-E | Human | Esophagus | ESCC | 1.97e-19 | 3.28e-01 | 0.1207 |
55219 | TMEM57 | P79T-E | Human | Esophagus | ESCC | 5.31e-17 | 3.40e-01 | 0.1154 |
55219 | TMEM57 | P80T-E | Human | Esophagus | ESCC | 3.05e-20 | 5.47e-01 | 0.155 |
55219 | TMEM57 | P82T-E | Human | Esophagus | ESCC | 5.61e-11 | 4.62e-01 | 0.1072 |
55219 | TMEM57 | P83T-E | Human | Esophagus | ESCC | 1.51e-17 | 3.96e-01 | 0.1738 |
55219 | TMEM57 | P84T-E | Human | Esophagus | ESCC | 4.44e-04 | 2.78e-01 | 0.0933 |
55219 | TMEM57 | P91T-E | Human | Esophagus | ESCC | 9.84e-10 | 6.92e-01 | 0.1828 |
55219 | TMEM57 | P104T-E | Human | Esophagus | ESCC | 2.11e-02 | 1.32e-01 | 0.0931 |
55219 | TMEM57 | P107T-E | Human | Esophagus | ESCC | 1.99e-15 | 3.55e-01 | 0.171 |
55219 | TMEM57 | P126T-E | Human | Esophagus | ESCC | 7.58e-07 | 8.27e-01 | 0.1125 |
55219 | TMEM57 | P127T-E | Human | Esophagus | ESCC | 3.36e-22 | 3.66e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM57 | SNV | Missense_Mutation | novel | c.1085N>A | p.Ser362Asn | p.S362N | Q8N5G2 | protein_coding | tolerated(0.49) | benign(0) | TCGA-A7-A0CD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TMEM57 | SNV | Missense_Mutation | novel | c.455G>T | p.Arg152Leu | p.R152L | Q8N5G2 | protein_coding | deleterious(0) | possibly_damaging(0.719) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TMEM57 | SNV | Missense_Mutation | c.1244C>T | p.Ser415Leu | p.S415L | Q8N5G2 | protein_coding | tolerated(0.82) | benign(0.024) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM57 | SNV | Missense_Mutation | c.1510G>A | p.Glu504Lys | p.E504K | Q8N5G2 | protein_coding | deleterious(0.01) | benign(0.146) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM57 | SNV | Missense_Mutation | novel | c.1846G>A | p.Glu616Lys | p.E616K | Q8N5G2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM57 | SNV | Missense_Mutation | c.1256N>T | p.Arg419Leu | p.R419L | Q8N5G2 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM57 | SNV | Missense_Mutation | c.1831N>G | p.Lys611Glu | p.K611E | Q8N5G2 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TMEM57 | SNV | Missense_Mutation | c.484N>T | p.Pro162Ser | p.P162S | Q8N5G2 | protein_coding | deleterious(0.04) | probably_damaging(0.961) | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
TMEM57 | SNV | Missense_Mutation | c.838N>C | p.Asp280His | p.D280H | Q8N5G2 | protein_coding | deleterious(0.04) | probably_damaging(0.983) | TCGA-B6-A0RT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM57 | SNV | Missense_Mutation | c.277C>A | p.Leu93Met | p.L93M | Q8N5G2 | protein_coding | deleterious(0.02) | possibly_damaging(0.897) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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