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Gene: TMEM209 |
Gene summary for TMEM209 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM209 | Gene ID | 84928 |
| Gene name | transmembrane protein 209 | |
| Gene Alias | NET31 | |
| Cytomap | 7q32.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96SK2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84928 | TMEM209 | P57T-E | Human | Esophagus | ESCC | 8.15e-05 | 9.95e-02 | 0.0926 |
| 84928 | TMEM209 | P61T-E | Human | Esophagus | ESCC | 3.98e-08 | 2.00e-01 | 0.099 |
| 84928 | TMEM209 | P62T-E | Human | Esophagus | ESCC | 5.02e-08 | 1.70e-01 | 0.1302 |
| 84928 | TMEM209 | P65T-E | Human | Esophagus | ESCC | 4.28e-08 | 1.92e-01 | 0.0978 |
| 84928 | TMEM209 | P74T-E | Human | Esophagus | ESCC | 7.09e-07 | 1.78e-01 | 0.1479 |
| 84928 | TMEM209 | P75T-E | Human | Esophagus | ESCC | 5.59e-12 | 2.70e-01 | 0.1125 |
| 84928 | TMEM209 | P76T-E | Human | Esophagus | ESCC | 2.78e-04 | 8.46e-02 | 0.1207 |
| 84928 | TMEM209 | P79T-E | Human | Esophagus | ESCC | 2.64e-21 | 4.34e-01 | 0.1154 |
| 84928 | TMEM209 | P80T-E | Human | Esophagus | ESCC | 1.30e-10 | 3.10e-01 | 0.155 |
| 84928 | TMEM209 | P83T-E | Human | Esophagus | ESCC | 1.82e-04 | 1.45e-01 | 0.1738 |
| 84928 | TMEM209 | P89T-E | Human | Esophagus | ESCC | 4.86e-05 | 2.86e-01 | 0.1752 |
| 84928 | TMEM209 | P91T-E | Human | Esophagus | ESCC | 8.74e-05 | 3.90e-01 | 0.1828 |
| 84928 | TMEM209 | P107T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.33e-01 | 0.171 |
| 84928 | TMEM209 | P126T-E | Human | Esophagus | ESCC | 6.92e-05 | 2.64e-01 | 0.1125 |
| 84928 | TMEM209 | P127T-E | Human | Esophagus | ESCC | 1.65e-03 | 9.55e-02 | 0.0826 |
| 84928 | TMEM209 | P128T-E | Human | Esophagus | ESCC | 3.46e-14 | 4.10e-01 | 0.1241 |
| 84928 | TMEM209 | P130T-E | Human | Esophagus | ESCC | 1.01e-31 | 6.77e-01 | 0.1676 |
| 84928 | TMEM209 | HCC1_Meng | Human | Liver | HCC | 3.30e-67 | 1.11e-01 | 0.0246 |
| 84928 | TMEM209 | HCC2_Meng | Human | Liver | HCC | 4.73e-06 | 1.79e-02 | 0.0107 |
| 84928 | TMEM209 | HCC2 | Human | Liver | HCC | 2.30e-06 | 2.42e+00 | 0.5341 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM209 | SNV | Missense_Mutation | c.736N>T | p.Leu246Phe | p.L246F | Q96SK2 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM209 | SNV | Missense_Mutation | c.424N>A | p.Tyr142Asn | p.Y142N | Q96SK2 | protein_coding | deleterious(0.02) | probably_damaging(0.929) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TMEM209 | SNV | Missense_Mutation | c.1030N>G | p.Asn344Asp | p.N344D | Q96SK2 | protein_coding | tolerated(0.06) | benign(0.089) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM209 | SNV | Missense_Mutation | novel | c.1060N>C | p.Glu354Gln | p.E354Q | Q96SK2 | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM209 | deletion | Frame_Shift_Del | novel | c.13delN | p.Glu5ArgfsTer15 | p.E5Rfs*15 | Q96SK2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| TMEM209 | SNV | Missense_Mutation | novel | c.1253C>A | p.Ser418Tyr | p.S418Y | Q96SK2 | protein_coding | deleterious(0) | possibly_damaging(0.452) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TMEM209 | SNV | Missense_Mutation | c.1289N>A | p.Arg430Lys | p.R430K | Q96SK2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EA-A3QD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
| TMEM209 | SNV | Missense_Mutation | c.645N>C | p.Leu215Phe | p.L215F | Q96SK2 | protein_coding | tolerated(0.16) | possibly_damaging(0.875) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM209 | SNV | Missense_Mutation | c.1105N>C | p.Glu369Gln | p.E369Q | Q96SK2 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| TMEM209 | SNV | Missense_Mutation | c.574N>G | p.Leu192Val | p.L192V | Q96SK2 | protein_coding | tolerated(0.51) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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