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Gene: TMEM159 |
Gene summary for TMEM159 |
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Gene information | Species | Human | Gene symbol | TMEM159 | Gene ID | 57146 |
Gene name | lipid droplet assembly factor 1 | |
Gene Alias | TMEM159 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96B96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57146 | TMEM159 | P47T-E | Human | Esophagus | ESCC | 7.00e-35 | 7.05e-01 | 0.1067 |
57146 | TMEM159 | P48T-E | Human | Esophagus | ESCC | 8.07e-19 | 4.82e-01 | 0.0959 |
57146 | TMEM159 | P49T-E | Human | Esophagus | ESCC | 4.16e-10 | 1.33e+00 | 0.1768 |
57146 | TMEM159 | P52T-E | Human | Esophagus | ESCC | 1.20e-23 | 7.20e-01 | 0.1555 |
57146 | TMEM159 | P54T-E | Human | Esophagus | ESCC | 8.61e-28 | 6.96e-01 | 0.0975 |
57146 | TMEM159 | P56T-E | Human | Esophagus | ESCC | 2.19e-04 | 1.06e+00 | 0.1613 |
57146 | TMEM159 | P57T-E | Human | Esophagus | ESCC | 4.51e-29 | 6.14e-01 | 0.0926 |
57146 | TMEM159 | P61T-E | Human | Esophagus | ESCC | 1.36e-11 | 3.87e-01 | 0.099 |
57146 | TMEM159 | P62T-E | Human | Esophagus | ESCC | 1.02e-68 | 1.29e+00 | 0.1302 |
57146 | TMEM159 | P65T-E | Human | Esophagus | ESCC | 8.59e-14 | 4.28e-01 | 0.0978 |
57146 | TMEM159 | P74T-E | Human | Esophagus | ESCC | 2.60e-24 | 7.84e-01 | 0.1479 |
57146 | TMEM159 | P75T-E | Human | Esophagus | ESCC | 3.07e-35 | 7.98e-01 | 0.1125 |
57146 | TMEM159 | P76T-E | Human | Esophagus | ESCC | 1.62e-38 | 7.22e-01 | 0.1207 |
57146 | TMEM159 | P79T-E | Human | Esophagus | ESCC | 3.46e-35 | 7.41e-01 | 0.1154 |
57146 | TMEM159 | P80T-E | Human | Esophagus | ESCC | 4.06e-49 | 1.57e+00 | 0.155 |
57146 | TMEM159 | P82T-E | Human | Esophagus | ESCC | 1.93e-22 | 1.30e+00 | 0.1072 |
57146 | TMEM159 | P83T-E | Human | Esophagus | ESCC | 3.43e-48 | 1.62e+00 | 0.1738 |
57146 | TMEM159 | P84T-E | Human | Esophagus | ESCC | 7.18e-19 | 1.57e+00 | 0.0933 |
57146 | TMEM159 | P89T-E | Human | Esophagus | ESCC | 7.23e-25 | 1.77e+00 | 0.1752 |
57146 | TMEM159 | P91T-E | Human | Esophagus | ESCC | 3.32e-08 | 1.07e+00 | 0.1828 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM159 | SNV | Missense_Mutation | rs780090255 | c.169N>A | p.Val57Met | p.V57M | Q96B96 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM159 | insertion | Nonsense_Mutation | novel | c.357_358insACCTTGGGAGGCCAAGGCAGGTGGATCACTTGA | p.Gly119_Gly120insThrLeuGlyGlyGlnGlyArgTrpIleThrTer | p.G119_G120insTLGGQGRWIT* | Q96B96 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
TMEM159 | insertion | Frame_Shift_Ins | novel | c.47_48insC | p.Gln17AlafsTer14 | p.Q17Afs*14 | Q96B96 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
TMEM159 | insertion | Nonsense_Mutation | novel | c.48_49insACTCCCCTCTGAGTTCCCATTATT | p.Leu16_Gln17insThrProLeuTerValProIleIle | p.L16_Q17insTPL*VPII | Q96B96 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
TMEM159 | insertion | Frame_Shift_Ins | novel | c.474_475insTGGGAATTGGGGGGACTGG | p.Arg159TrpfsTer17 | p.R159Wfs*17 | Q96B96 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM159 | SNV | Missense_Mutation | novel | c.76T>A | p.Ser26Thr | p.S26T | Q96B96 | protein_coding | tolerated(0.25) | possibly_damaging(0.689) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM159 | SNV | Missense_Mutation | c.283C>T | p.Leu95Phe | p.L95F | Q96B96 | protein_coding | tolerated(0.15) | benign(0.09) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TMEM159 | SNV | Missense_Mutation | rs372605849 | c.413N>T | p.Ser138Leu | p.S138L | Q96B96 | protein_coding | deleterious(0.03) | benign(0.044) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM159 | SNV | Missense_Mutation | c.370N>A | p.Leu124Ile | p.L124I | Q96B96 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM159 | SNV | Missense_Mutation | novel | c.311C>T | p.Ala104Val | p.A104V | Q96B96 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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