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Gene: TMEM141 |
Gene summary for TMEM141 |
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Gene information | Species | Human | Gene symbol | TMEM141 | Gene ID | 85014 |
Gene name | transmembrane protein 141 | |
Gene Alias | TMEM141 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96I45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85014 | TMEM141 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.54e-35 | 9.15e-01 | -0.1207 |
85014 | TMEM141 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.16e-33 | 9.52e-01 | -0.1526 |
85014 | TMEM141 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.41e-57 | 1.05e+00 | -0.1464 |
85014 | TMEM141 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.41e-57 | 9.51e-01 | -0.1001 |
85014 | TMEM141 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.32e-54 | 1.56e+00 | -0.059 |
85014 | TMEM141 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.92e-24 | 1.03e+00 | -0.1706 |
85014 | TMEM141 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.34e-19 | 7.47e-01 | -0.2061 |
85014 | TMEM141 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.35e-17 | 8.93e-01 | -0.1462 |
85014 | TMEM141 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.81e-22 | 7.79e-01 | -0.0842 |
85014 | TMEM141 | HTA11_9341_2000001011 | Human | Colorectum | SER | 6.42e-18 | 1.05e+00 | -0.00410000000000005 |
85014 | TMEM141 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.33e-23 | 7.45e-01 | -0.0179 |
85014 | TMEM141 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.56e-58 | 1.09e+00 | 0.096 |
85014 | TMEM141 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.87e-16 | 6.52e-01 | 0.0446 |
85014 | TMEM141 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.07e-17 | 9.13e-01 | 0.0451 |
85014 | TMEM141 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.04e-19 | 6.72e-01 | 0.0528 |
85014 | TMEM141 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.50e-28 | 1.13e+00 | 0.0131 |
85014 | TMEM141 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.17e-33 | 1.19e+00 | -0.0177 |
85014 | TMEM141 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.41e-22 | 1.30e+00 | 0.0171 |
85014 | TMEM141 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.90e-37 | 9.56e-01 | 0.0338 |
85014 | TMEM141 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.94e-44 | 8.24e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM141 | SNV | Missense_Mutation | novel | c.182N>G | p.Gln61Arg | p.Q61R | Q96I45 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-AA-3955-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | capecitabine | CR |
TMEM141 | SNV | Missense_Mutation | c.176N>A | p.Pro59His | p.P59H | Q96I45 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM141 | SNV | Missense_Mutation | c.93C>A | p.Phe31Leu | p.F31L | Q96I45 | protein_coding | tolerated(0.3) | probably_damaging(0.971) | TCGA-EY-A1GS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
TMEM141 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Leu | p.S28L | Q96I45 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
TMEM141 | SNV | Missense_Mutation | novel | c.160A>G | p.Arg54Gly | p.R54G | Q96I45 | protein_coding | deleterious(0) | possibly_damaging(0.501) | TCGA-VQ-A91S-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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