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Gene: TIMP3 |
Gene summary for TIMP3 |
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Gene information | Species | Human | Gene symbol | TIMP3 | Gene ID | 7078 |
Gene name | TIMP metallopeptidase inhibitor 3 | |
Gene Alias | HSMRK222 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P35625 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7078 | TIMP3 | S43 | Human | Liver | Cirrhotic | 2.98e-04 | 2.14e-01 | -0.0187 |
7078 | TIMP3 | HCC1_Meng | Human | Liver | HCC | 8.04e-08 | -1.50e-01 | 0.0246 |
7078 | TIMP3 | cirrhotic3 | Human | Liver | Cirrhotic | 1.12e-04 | 1.86e-01 | 0.0215 |
7078 | TIMP3 | HCC1 | Human | Liver | HCC | 1.95e-04 | 3.73e+00 | 0.5336 |
7078 | TIMP3 | HCC2 | Human | Liver | HCC | 7.47e-05 | 2.50e+00 | 0.5341 |
7078 | TIMP3 | Pt13.a | Human | Liver | HCC | 1.59e-05 | 2.46e-01 | 0.021 |
7078 | TIMP3 | Pt13.b | Human | Liver | HCC | 7.14e-40 | 8.17e-01 | 0.0251 |
7078 | TIMP3 | Pt14.b | Human | Liver | HCC | 1.18e-04 | 2.30e-01 | 0.018 |
7078 | TIMP3 | S014 | Human | Liver | HCC | 3.13e-17 | 1.91e+00 | 0.2254 |
7078 | TIMP3 | S015 | Human | Liver | HCC | 4.21e-17 | 1.98e+00 | 0.2375 |
7078 | TIMP3 | S016 | Human | Liver | HCC | 4.01e-15 | 1.30e+00 | 0.2243 |
7078 | TIMP3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.03e-03 | 3.48e-01 | -0.2116 |
7078 | TIMP3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.63e-04 | 4.21e-01 | -0.2119 |
7078 | TIMP3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.97e-05 | 3.20e-01 | -0.0166 |
7078 | TIMP3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.83e-13 | 4.92e-01 | -0.0132 |
7078 | TIMP3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.93e-10 | 4.53e-01 | -0.013 |
7078 | TIMP3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 8.23e-08 | 3.90e-01 | -0.0121 |
7078 | TIMP3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.54e-06 | 7.02e-01 | -0.0876 |
7078 | TIMP3 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.34e-02 | 5.12e-01 | -0.0822 |
7078 | TIMP3 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.44e-03 | 5.37e-01 | -0.0809 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:200123514 | Breast | IDC | positive regulation of apoptotic signaling pathway | 31/1434 | 126/18723 | 4.13e-09 | 3.35e-07 | 31 |
GO:004217614 | Breast | IDC | regulation of protein catabolic process | 63/1434 | 391/18723 | 1.32e-08 | 9.61e-07 | 63 |
GO:009719114 | Breast | IDC | extrinsic apoptotic signaling pathway | 42/1434 | 219/18723 | 2.56e-08 | 1.73e-06 | 42 |
GO:200123614 | Breast | IDC | regulation of extrinsic apoptotic signaling pathway | 32/1434 | 151/18723 | 1.07e-07 | 6.26e-06 | 32 |
GO:20012385 | Breast | IDC | positive regulation of extrinsic apoptotic signaling pathway | 12/1434 | 48/18723 | 2.03e-04 | 3.32e-03 | 12 |
GO:003133014 | Breast | IDC | negative regulation of cellular catabolic process | 37/1434 | 262/18723 | 2.20e-04 | 3.52e-03 | 37 |
GO:00703713 | Breast | IDC | ERK1 and ERK2 cascade | 43/1434 | 330/18723 | 4.28e-04 | 5.84e-03 | 43 |
GO:004217714 | Breast | IDC | negative regulation of protein catabolic process | 20/1434 | 121/18723 | 8.51e-04 | 9.92e-03 | 20 |
GO:190204112 | Breast | IDC | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 11/1434 | 49/18723 | 9.88e-04 | 1.11e-02 | 11 |
GO:000989514 | Breast | IDC | negative regulation of catabolic process | 40/1434 | 320/18723 | 1.49e-03 | 1.50e-02 | 40 |
GO:19020432 | Breast | IDC | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | 5/1434 | 13/18723 | 2.00e-03 | 1.90e-02 | 5 |
GO:00703733 | Breast | IDC | negative regulation of ERK1 and ERK2 cascade | 14/1434 | 78/18723 | 2.21e-03 | 2.06e-02 | 14 |
GO:00703722 | Breast | IDC | regulation of ERK1 and ERK2 cascade | 37/1434 | 309/18723 | 4.53e-03 | 3.49e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0520542 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0520552 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0520510 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0520511 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
hsa0520521 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0520531 | Liver | HCC | Proteoglycans in cancer | 121/4020 | 205/8465 | 5.22e-04 | 2.18e-03 | 1.21e-03 | 121 |
hsa0520512 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0520513 | Lung | IAC | Proteoglycans in cancer | 53/1053 | 205/8465 | 9.47e-08 | 6.16e-06 | 4.09e-06 | 53 |
hsa0520522 | Lung | AIS | Proteoglycans in cancer | 52/961 | 205/8465 | 1.16e-08 | 5.38e-07 | 3.44e-07 | 52 |
hsa0520532 | Lung | AIS | Proteoglycans in cancer | 52/961 | 205/8465 | 1.16e-08 | 5.38e-07 | 3.44e-07 | 52 |
hsa0520526 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa05205111 | Oral cavity | OSCC | Proteoglycans in cancer | 128/3704 | 205/8465 | 4.00e-08 | 3.12e-07 | 1.59e-07 | 128 |
hsa0520562 | Oral cavity | NEOLP | Proteoglycans in cancer | 56/1112 | 205/8465 | 3.49e-08 | 5.85e-07 | 3.68e-07 | 56 |
hsa0520572 | Oral cavity | NEOLP | Proteoglycans in cancer | 56/1112 | 205/8465 | 3.49e-08 | 5.85e-07 | 3.68e-07 | 56 |
hsa0520520 | Prostate | BPH | Proteoglycans in cancer | 72/1718 | 205/8465 | 4.16e-07 | 4.10e-06 | 2.54e-06 | 72 |
hsa05205110 | Prostate | BPH | Proteoglycans in cancer | 72/1718 | 205/8465 | 4.16e-07 | 4.10e-06 | 2.54e-06 | 72 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMP3 | SNV | Missense_Mutation | novel | c.308T>C | p.Leu103Pro | p.L103P | P35625 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A3XY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
TIMP3 | SNV | Missense_Mutation | c.504N>A | p.Met168Ile | p.M168I | P35625 | protein_coding | deleterious(0.02) | benign(0.041) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TIMP3 | SNV | Missense_Mutation | c.441C>G | p.Ile147Met | p.I147M | P35625 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TIMP3 | SNV | Missense_Mutation | c.421C>A | p.Leu141Met | p.L141M | P35625 | protein_coding | tolerated(1) | probably_damaging(0.994) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TIMP3 | SNV | Missense_Mutation | novel | c.241N>C | p.Tyr81His | p.Y81H | P35625 | protein_coding | tolerated(0.3) | benign(0.015) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIMP3 | SNV | Missense_Mutation | c.319N>T | p.Arg107Cys | p.R107C | P35625 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TIMP3 | SNV | Missense_Mutation | rs773990898 | c.517G>A | p.Gly173Ser | p.G173S | P35625 | protein_coding | tolerated(0.68) | probably_damaging(0.985) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TIMP3 | SNV | Missense_Mutation | c.151N>A | p.Leu51Met | p.L51M | P35625 | protein_coding | tolerated(0.26) | possibly_damaging(0.769) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TIMP3 | SNV | Missense_Mutation | novel | c.313N>C | p.Thr105Pro | p.T105P | P35625 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TIMP3 | SNV | Missense_Mutation | rs1804709 | c.628G>T | p.Asp210Tyr | p.D210Y | P35625 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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