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Gene: TCEB3 |
Gene summary for TCEB3 |
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Gene information | Species | Human | Gene symbol | TCEB3 | Gene ID | 6924 |
Gene name | elongin A | |
Gene Alias | SIII | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6924 | TCEB3 | P76T-E | Human | Esophagus | ESCC | 7.39e-13 | 3.11e-01 | 0.1207 |
6924 | TCEB3 | P79T-E | Human | Esophagus | ESCC | 6.17e-19 | 1.80e-01 | 0.1154 |
6924 | TCEB3 | P80T-E | Human | Esophagus | ESCC | 1.10e-21 | 8.66e-01 | 0.155 |
6924 | TCEB3 | P82T-E | Human | Esophagus | ESCC | 1.16e-07 | 6.00e-01 | 0.1072 |
6924 | TCEB3 | P83T-E | Human | Esophagus | ESCC | 1.36e-11 | 5.36e-01 | 0.1738 |
6924 | TCEB3 | P84T-E | Human | Esophagus | ESCC | 1.72e-02 | 1.31e-01 | 0.0933 |
6924 | TCEB3 | P89T-E | Human | Esophagus | ESCC | 4.53e-05 | 5.04e-01 | 0.1752 |
6924 | TCEB3 | P91T-E | Human | Esophagus | ESCC | 1.19e-07 | 1.08e+00 | 0.1828 |
6924 | TCEB3 | P104T-E | Human | Esophagus | ESCC | 9.79e-04 | 2.45e-01 | 0.0931 |
6924 | TCEB3 | P107T-E | Human | Esophagus | ESCC | 2.62e-34 | 8.71e-01 | 0.171 |
6924 | TCEB3 | P127T-E | Human | Esophagus | ESCC | 4.05e-20 | 1.06e-01 | 0.0826 |
6924 | TCEB3 | P128T-E | Human | Esophagus | ESCC | 3.28e-32 | 1.32e+00 | 0.1241 |
6924 | TCEB3 | P130T-E | Human | Esophagus | ESCC | 2.10e-37 | 8.50e-01 | 0.1676 |
6924 | TCEB3 | C04 | Human | Oral cavity | OSCC | 1.94e-16 | 7.02e-01 | 0.2633 |
6924 | TCEB3 | C21 | Human | Oral cavity | OSCC | 2.22e-42 | 1.14e+00 | 0.2678 |
6924 | TCEB3 | C30 | Human | Oral cavity | OSCC | 2.96e-36 | 1.37e+00 | 0.3055 |
6924 | TCEB3 | C38 | Human | Oral cavity | OSCC | 3.85e-05 | 5.85e-01 | 0.172 |
6924 | TCEB3 | C43 | Human | Oral cavity | OSCC | 8.86e-28 | 4.94e-01 | 0.1704 |
6924 | TCEB3 | C46 | Human | Oral cavity | OSCC | 1.97e-08 | 2.84e-01 | 0.1673 |
6924 | TCEB3 | C51 | Human | Oral cavity | OSCC | 6.43e-14 | 6.39e-01 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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