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Gene: SUPT4H1 |
Gene summary for SUPT4H1 |
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Gene information | Species | Human | Gene symbol | SUPT4H1 | Gene ID | 6827 |
Gene name | SPT4 homolog, DSIF elongation factor subunit | |
Gene Alias | SPT4 | |
Cytomap | 17q22 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P63272 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6827 | SUPT4H1 | EEC-subject1 | Human | Endometrium | EEC | 7.64e-21 | -3.92e-01 | -0.2682 |
6827 | SUPT4H1 | EEC-subject2 | Human | Endometrium | EEC | 6.76e-19 | -3.74e-01 | -0.2607 |
6827 | SUPT4H1 | EEC-subject3 | Human | Endometrium | EEC | 1.25e-35 | -4.12e-01 | -0.2525 |
6827 | SUPT4H1 | EEC-subject4 | Human | Endometrium | EEC | 5.38e-10 | -2.77e-01 | -0.2571 |
6827 | SUPT4H1 | EEC-subject5 | Human | Endometrium | EEC | 1.96e-08 | -2.53e-01 | -0.249 |
6827 | SUPT4H1 | GSM5276934 | Human | Endometrium | EEC | 2.71e-07 | -2.65e-01 | -0.0913 |
6827 | SUPT4H1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.48e-28 | -5.05e-01 | -0.1869 |
6827 | SUPT4H1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.91e-23 | -4.87e-01 | -0.1875 |
6827 | SUPT4H1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.86e-29 | -5.05e-01 | -0.1883 |
6827 | SUPT4H1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.09e-41 | -5.05e-01 | -0.1934 |
6827 | SUPT4H1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.09e-41 | -5.05e-01 | -0.1917 |
6827 | SUPT4H1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.68e-37 | -5.05e-01 | -0.1916 |
6827 | SUPT4H1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.70e-03 | -1.22e-01 | -0.1269 |
6827 | SUPT4H1 | LZE4T | Human | Esophagus | ESCC | 7.90e-19 | 4.49e-01 | 0.0811 |
6827 | SUPT4H1 | LZE5T | Human | Esophagus | ESCC | 1.87e-07 | 7.26e-01 | 0.0514 |
6827 | SUPT4H1 | LZE7T | Human | Esophagus | ESCC | 1.18e-08 | 8.56e-01 | 0.0667 |
6827 | SUPT4H1 | LZE8T | Human | Esophagus | ESCC | 3.49e-05 | 2.86e-01 | 0.067 |
6827 | SUPT4H1 | LZE22D1 | Human | Esophagus | HGIN | 5.02e-04 | 8.64e-02 | 0.0595 |
6827 | SUPT4H1 | LZE22T | Human | Esophagus | ESCC | 1.29e-03 | 4.42e-01 | 0.068 |
6827 | SUPT4H1 | LZE24T | Human | Esophagus | ESCC | 2.69e-27 | 8.83e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0006368 | Colorectum | AD | transcription elongation from RNA polymerase II promoter | 24/3918 | 69/18723 | 5.35e-03 | 3.52e-02 | 24 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00063541 | Colorectum | MSS | DNA-templated transcription, elongation | 29/3467 | 91/18723 | 1.52e-03 | 1.39e-02 | 29 |
GO:00327861 | Colorectum | MSS | positive regulation of DNA-templated transcription, elongation | 12/3467 | 27/18723 | 1.74e-03 | 1.55e-02 | 12 |
GO:00063681 | Colorectum | MSS | transcription elongation from RNA polymerase II promoter | 22/3467 | 69/18723 | 5.31e-03 | 3.62e-02 | 22 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00327862 | Colorectum | FAP | positive regulation of DNA-templated transcription, elongation | 11/2622 | 27/18723 | 5.93e-04 | 6.58e-03 | 11 |
GO:00063682 | Colorectum | FAP | transcription elongation from RNA polymerase II promoter | 20/2622 | 69/18723 | 9.25e-04 | 9.26e-03 | 20 |
GO:00063542 | Colorectum | FAP | DNA-templated transcription, elongation | 24/2622 | 91/18723 | 1.32e-03 | 1.22e-02 | 24 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
GO:00063687 | Esophagus | HGIN | transcription elongation from RNA polymerase II promoter | 24/2587 | 69/18723 | 8.93e-06 | 2.64e-04 | 24 |
GO:00063548 | Esophagus | HGIN | DNA-templated transcription, elongation | 27/2587 | 91/18723 | 6.62e-05 | 1.52e-03 | 27 |
GO:00342435 | Esophagus | HGIN | regulation of transcription elongation from RNA polymerase II promoter | 13/2587 | 32/18723 | 1.72e-04 | 3.32e-03 | 13 |
GO:00327866 | Esophagus | HGIN | positive regulation of DNA-templated transcription, elongation | 11/2587 | 27/18723 | 5.28e-04 | 7.56e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03250 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa032501 | Colorectum | MSS | Viral life cycle - HIV-1 | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa032502 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0325011 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa032508 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa0325013 | Oral cavity | OSCC | Viral life cycle - HIV-1 | 45/3704 | 63/8465 | 7.62e-06 | 3.59e-05 | 1.83e-05 | 45 |
hsa0325022 | Oral cavity | LP | Viral life cycle - HIV-1 | 32/2418 | 63/8465 | 1.55e-04 | 9.08e-04 | 5.86e-04 | 32 |
hsa0325031 | Oral cavity | LP | Viral life cycle - HIV-1 | 32/2418 | 63/8465 | 1.55e-04 | 9.08e-04 | 5.86e-04 | 32 |
hsa032504 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa0325012 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa0325021 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
hsa032503 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUPT4H1 | SNV | Missense_Mutation | rs771855308 | c.185N>T | p.Ala62Val | p.A62V | P63272 | protein_coding | deleterious(0.02) | possibly_damaging(0.592) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SUPT4H1 | SNV | Missense_Mutation | novel | c.275N>A | p.Arg92His | p.R92H | P63272 | protein_coding | deleterious(0) | benign(0.26) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT4H1 | SNV | Missense_Mutation | c.203N>G | p.Asp68Gly | p.D68G | P63272 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SUPT4H1 | SNV | Missense_Mutation | novel | c.76N>T | p.Asp26Tyr | p.D26Y | P63272 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SUPT4H1 | SNV | Missense_Mutation | novel | c.295N>T | p.Arg99Trp | p.R99W | P63272 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT4H1 | SNV | Missense_Mutation | rs771855308 | c.185N>T | p.Ala62Val | p.A62V | P63272 | protein_coding | deleterious(0.02) | possibly_damaging(0.592) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT4H1 | SNV | Missense_Mutation | c.290T>A | p.Ile97Asn | p.I97N | P63272 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-DD-A4NV-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SUPT4H1 | SNV | Missense_Mutation | c.188T>C | p.Met63Thr | p.M63T | P63272 | protein_coding | deleterious(0.03) | possibly_damaging(0.708) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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