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Gene: STARD3NL |
Gene summary for STARD3NL |
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Gene information | Species | Human | Gene symbol | STARD3NL | Gene ID | 83930 |
Gene name | STARD3 N-terminal like | |
Gene Alias | MENTHO | |
Cytomap | 7p14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024RA89 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83930 | STARD3NL | P54T-E | Human | Esophagus | ESCC | 3.54e-18 | 4.18e-01 | 0.0975 |
83930 | STARD3NL | P56T-E | Human | Esophagus | ESCC | 5.35e-11 | 1.12e+00 | 0.1613 |
83930 | STARD3NL | P57T-E | Human | Esophagus | ESCC | 4.64e-26 | 5.57e-01 | 0.0926 |
83930 | STARD3NL | P61T-E | Human | Esophagus | ESCC | 6.82e-22 | 4.91e-01 | 0.099 |
83930 | STARD3NL | P62T-E | Human | Esophagus | ESCC | 1.32e-37 | 6.90e-01 | 0.1302 |
83930 | STARD3NL | P65T-E | Human | Esophagus | ESCC | 8.67e-08 | 1.87e-01 | 0.0978 |
83930 | STARD3NL | P74T-E | Human | Esophagus | ESCC | 9.15e-40 | 1.08e+00 | 0.1479 |
83930 | STARD3NL | P75T-E | Human | Esophagus | ESCC | 2.65e-32 | 6.31e-01 | 0.1125 |
83930 | STARD3NL | P76T-E | Human | Esophagus | ESCC | 2.56e-54 | 8.41e-01 | 0.1207 |
83930 | STARD3NL | P79T-E | Human | Esophagus | ESCC | 1.12e-25 | 4.27e-01 | 0.1154 |
83930 | STARD3NL | P80T-E | Human | Esophagus | ESCC | 3.27e-32 | 8.68e-01 | 0.155 |
83930 | STARD3NL | P82T-E | Human | Esophagus | ESCC | 7.05e-14 | 1.04e+00 | 0.1072 |
83930 | STARD3NL | P83T-E | Human | Esophagus | ESCC | 6.89e-50 | 1.38e+00 | 0.1738 |
83930 | STARD3NL | P89T-E | Human | Esophagus | ESCC | 7.34e-24 | 1.65e+00 | 0.1752 |
83930 | STARD3NL | P91T-E | Human | Esophagus | ESCC | 2.66e-13 | 1.34e+00 | 0.1828 |
83930 | STARD3NL | P107T-E | Human | Esophagus | ESCC | 2.74e-22 | 5.86e-01 | 0.171 |
83930 | STARD3NL | P126T-E | Human | Esophagus | ESCC | 1.66e-09 | 6.02e-01 | 0.1125 |
83930 | STARD3NL | P127T-E | Human | Esophagus | ESCC | 3.34e-11 | 2.00e-01 | 0.0826 |
83930 | STARD3NL | P128T-E | Human | Esophagus | ESCC | 4.23e-37 | 1.00e+00 | 0.1241 |
83930 | STARD3NL | P130T-E | Human | Esophagus | ESCC | 3.93e-50 | 1.01e+00 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
GO:005165010 | Esophagus | HGIN | establishment of vesicle localization | 35/2587 | 161/18723 | 3.89e-03 | 3.54e-02 | 35 |
GO:005164810 | Esophagus | HGIN | vesicle localization | 37/2587 | 177/18723 | 6.03e-03 | 4.87e-02 | 37 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:00990222 | Esophagus | ESCC | vesicle tethering | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:005165021 | Liver | HCC | establishment of vesicle localization | 103/7958 | 161/18723 | 2.94e-08 | 6.69e-07 | 103 |
GO:005164821 | Liver | HCC | vesicle localization | 107/7958 | 177/18723 | 1.05e-06 | 1.57e-05 | 107 |
GO:000690311 | Liver | HCC | vesicle targeting | 34/7958 | 45/18723 | 6.75e-06 | 8.08e-05 | 34 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:00069037 | Oral cavity | OSCC | vesicle targeting | 38/7305 | 45/18723 | 4.49e-10 | 1.19e-08 | 38 |
GO:00516509 | Oral cavity | OSCC | establishment of vesicle localization | 101/7305 | 161/18723 | 8.79e-10 | 2.17e-08 | 101 |
GO:00516489 | Oral cavity | OSCC | vesicle localization | 105/7305 | 177/18723 | 3.30e-08 | 6.30e-07 | 105 |
GO:0099022 | Oral cavity | OSCC | vesicle tethering | 10/7305 | 11/18723 | 5.78e-04 | 3.30e-03 | 10 |
GO:005165623 | Oral cavity | EOLP | establishment of organelle localization | 73/2218 | 390/18723 | 4.59e-05 | 6.11e-04 | 73 |
GO:005165022 | Oral cavity | EOLP | establishment of vesicle localization | 35/2218 | 161/18723 | 2.54e-04 | 2.47e-03 | 35 |
GO:005164822 | Oral cavity | EOLP | vesicle localization | 37/2218 | 177/18723 | 3.88e-04 | 3.48e-03 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STARD3NL | SNV | Missense_Mutation | c.44G>C | p.Ser15Thr | p.S15T | O95772 | protein_coding | tolerated(0.28) | possibly_damaging(0.906) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
STARD3NL | SNV | Missense_Mutation | novel | c.637N>A | p.Glu213Lys | p.E213K | O95772 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
STARD3NL | SNV | Missense_Mutation | c.336N>G | p.Ile112Met | p.I112M | O95772 | protein_coding | deleterious(0.03) | probably_damaging(0.958) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
STARD3NL | SNV | Missense_Mutation | rs767198270 | c.296A>G | p.Asp99Gly | p.D99G | O95772 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
STARD3NL | SNV | Missense_Mutation | c.296N>T | p.Asp99Val | p.D99V | O95772 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
STARD3NL | SNV | Missense_Mutation | c.52N>C | p.Ser18Pro | p.S18P | O95772 | protein_coding | tolerated(0.09) | benign(0.021) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STARD3NL | SNV | Missense_Mutation | novel | c.101T>C | p.Met34Thr | p.M34T | O95772 | protein_coding | tolerated(0.39) | benign(0.015) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STARD3NL | SNV | Missense_Mutation | rs141608996 | c.643N>A | p.Glu215Lys | p.E215K | O95772 | protein_coding | tolerated(0.07) | benign(0.071) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STARD3NL | SNV | Missense_Mutation | c.235N>A | p.Gly79Ser | p.G79S | O95772 | protein_coding | tolerated(0.17) | possibly_damaging(0.714) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STARD3NL | SNV | Missense_Mutation | rs760254369 | c.320N>A | p.Arg107Gln | p.R107Q | O95772 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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