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Gene: SRFBP1 |
Gene summary for SRFBP1 |
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Gene information | Species | Human | Gene symbol | SRFBP1 | Gene ID | 153443 |
Gene name | serum response factor binding protein 1 | |
Gene Alias | BUD22 | |
Cytomap | 5q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NEF9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153443 | SRFBP1 | P61T-E | Human | Esophagus | ESCC | 1.50e-10 | 2.59e-01 | 0.099 |
153443 | SRFBP1 | P62T-E | Human | Esophagus | ESCC | 1.01e-30 | 6.26e-01 | 0.1302 |
153443 | SRFBP1 | P65T-E | Human | Esophagus | ESCC | 2.39e-06 | 1.61e-01 | 0.0978 |
153443 | SRFBP1 | P74T-E | Human | Esophagus | ESCC | 2.71e-15 | 4.55e-01 | 0.1479 |
153443 | SRFBP1 | P75T-E | Human | Esophagus | ESCC | 7.06e-31 | 5.13e-01 | 0.1125 |
153443 | SRFBP1 | P76T-E | Human | Esophagus | ESCC | 1.14e-25 | 4.62e-01 | 0.1207 |
153443 | SRFBP1 | P79T-E | Human | Esophagus | ESCC | 7.78e-20 | 3.47e-01 | 0.1154 |
153443 | SRFBP1 | P80T-E | Human | Esophagus | ESCC | 1.06e-29 | 8.58e-01 | 0.155 |
153443 | SRFBP1 | P82T-E | Human | Esophagus | ESCC | 1.11e-08 | 3.35e-01 | 0.1072 |
153443 | SRFBP1 | P83T-E | Human | Esophagus | ESCC | 9.53e-23 | 6.49e-01 | 0.1738 |
153443 | SRFBP1 | P89T-E | Human | Esophagus | ESCC | 8.44e-11 | 5.91e-01 | 0.1752 |
153443 | SRFBP1 | P91T-E | Human | Esophagus | ESCC | 7.01e-04 | 7.55e-01 | 0.1828 |
153443 | SRFBP1 | P107T-E | Human | Esophagus | ESCC | 5.07e-26 | 6.60e-01 | 0.171 |
153443 | SRFBP1 | P126T-E | Human | Esophagus | ESCC | 2.91e-07 | 7.87e-01 | 0.1125 |
153443 | SRFBP1 | P127T-E | Human | Esophagus | ESCC | 1.14e-24 | 3.90e-01 | 0.0826 |
153443 | SRFBP1 | P128T-E | Human | Esophagus | ESCC | 2.33e-14 | 3.98e-01 | 0.1241 |
153443 | SRFBP1 | P130T-E | Human | Esophagus | ESCC | 1.01e-43 | 7.86e-01 | 0.1676 |
153443 | SRFBP1 | S43 | Human | Liver | Cirrhotic | 4.75e-03 | -6.64e-02 | -0.0187 |
153443 | SRFBP1 | HCC1_Meng | Human | Liver | HCC | 8.91e-62 | 1.60e-01 | 0.0246 |
153443 | SRFBP1 | HCC2_Meng | Human | Liver | HCC | 1.32e-07 | 5.05e-03 | 0.0107 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:004227412 | Liver | Cirrhotic | ribosomal small subunit biogenesis | 42/4634 | 73/18723 | 2.34e-09 | 9.73e-08 | 42 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:0030490 | Liver | Cirrhotic | maturation of SSU-rRNA | 24/4634 | 50/18723 | 3.06e-04 | 2.68e-03 | 24 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRFBP1 | SNV | Missense_Mutation | c.763N>C | p.Glu255Gln | p.E255Q | Q8NEF9 | protein_coding | tolerated(0.13) | benign(0.123) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SRFBP1 | SNV | Missense_Mutation | c.749N>A | p.Gly250Glu | p.G250E | Q8NEF9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRFBP1 | SNV | Missense_Mutation | c.932N>C | p.Glu311Ala | p.E311A | Q8NEF9 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SRFBP1 | SNV | Missense_Mutation | c.454A>G | p.Asn152Asp | p.N152D | Q8NEF9 | protein_coding | tolerated(0.13) | benign(0.058) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
SRFBP1 | SNV | Missense_Mutation | c.620C>A | p.Pro207His | p.P207H | Q8NEF9 | protein_coding | deleterious(0.01) | benign(0.084) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SRFBP1 | SNV | Missense_Mutation | rs376474484 | c.478C>T | p.Arg160Cys | p.R160C | Q8NEF9 | protein_coding | deleterious(0.04) | benign(0.183) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
SRFBP1 | SNV | Missense_Mutation | novel | c.1274N>A | p.Ile425Asn | p.I425N | Q8NEF9 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
SRFBP1 | SNV | Missense_Mutation | novel | c.943N>A | p.Leu315Ile | p.L315I | Q8NEF9 | protein_coding | tolerated(0.36) | benign(0.069) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SRFBP1 | SNV | Missense_Mutation | c.894N>G | p.Ser298Arg | p.S298R | Q8NEF9 | protein_coding | tolerated(0.07) | benign(0.289) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SRFBP1 | SNV | Missense_Mutation | c.555G>T | p.Lys185Asn | p.K185N | Q8NEF9 | protein_coding | tolerated(0.12) | possibly_damaging(0.541) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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