![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SPRTN |
Gene summary for SPRTN |
![]() |
Gene information | Species | Human | Gene symbol | SPRTN | Gene ID | 83932 |
Gene name | SprT-like N-terminal domain | |
Gene Alias | C1orf124 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0000731 | UniProtAcc | Q9H040 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83932 | SPRTN | P56T-E | Human | Esophagus | ESCC | 4.99e-07 | 5.76e-01 | 0.1613 |
83932 | SPRTN | P57T-E | Human | Esophagus | ESCC | 3.30e-09 | 1.85e-01 | 0.0926 |
83932 | SPRTN | P61T-E | Human | Esophagus | ESCC | 2.44e-21 | 4.09e-01 | 0.099 |
83932 | SPRTN | P62T-E | Human | Esophagus | ESCC | 1.97e-28 | 4.56e-01 | 0.1302 |
83932 | SPRTN | P65T-E | Human | Esophagus | ESCC | 1.35e-09 | 1.98e-01 | 0.0978 |
83932 | SPRTN | P74T-E | Human | Esophagus | ESCC | 6.06e-16 | 4.06e-01 | 0.1479 |
83932 | SPRTN | P75T-E | Human | Esophagus | ESCC | 2.22e-25 | 3.84e-01 | 0.1125 |
83932 | SPRTN | P76T-E | Human | Esophagus | ESCC | 9.32e-20 | 2.71e-01 | 0.1207 |
83932 | SPRTN | P79T-E | Human | Esophagus | ESCC | 3.58e-10 | 1.62e-01 | 0.1154 |
83932 | SPRTN | P80T-E | Human | Esophagus | ESCC | 1.08e-18 | 4.81e-01 | 0.155 |
83932 | SPRTN | P82T-E | Human | Esophagus | ESCC | 2.07e-07 | 4.08e-01 | 0.1072 |
83932 | SPRTN | P83T-E | Human | Esophagus | ESCC | 6.30e-15 | 4.21e-01 | 0.1738 |
83932 | SPRTN | P84T-E | Human | Esophagus | ESCC | 2.32e-08 | 3.74e-01 | 0.0933 |
83932 | SPRTN | P89T-E | Human | Esophagus | ESCC | 1.67e-06 | 3.31e-01 | 0.1752 |
83932 | SPRTN | P91T-E | Human | Esophagus | ESCC | 8.07e-12 | 8.04e-01 | 0.1828 |
83932 | SPRTN | P107T-E | Human | Esophagus | ESCC | 1.83e-19 | 3.78e-01 | 0.171 |
83932 | SPRTN | P126T-E | Human | Esophagus | ESCC | 2.50e-02 | 3.05e-01 | 0.1125 |
83932 | SPRTN | P127T-E | Human | Esophagus | ESCC | 4.76e-07 | 1.07e-01 | 0.0826 |
83932 | SPRTN | P128T-E | Human | Esophagus | ESCC | 2.09e-14 | 4.53e-01 | 0.1241 |
83932 | SPRTN | P130T-E | Human | Esophagus | ESCC | 2.88e-42 | 8.27e-01 | 0.1676 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:007189716 | Esophagus | ESCC | DNA biosynthetic process | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:00063012 | Esophagus | ESCC | postreplication repair | 26/8552 | 31/18723 | 1.32e-05 | 1.21e-04 | 26 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:0019985 | Esophagus | ESCC | translesion synthesis | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
GO:190332020 | Oral cavity | OSCC | regulation of protein modification by small protein conjugation or removal | 165/7305 | 242/18723 | 2.52e-20 | 3.99e-18 | 165 |
GO:003139620 | Oral cavity | OSCC | regulation of protein ubiquitination | 143/7305 | 210/18723 | 1.01e-17 | 9.80e-16 | 143 |
GO:00094114 | Oral cavity | OSCC | response to UV | 99/7305 | 149/18723 | 1.01e-11 | 3.70e-10 | 99 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:000931416 | Oral cavity | OSCC | response to radiation | 241/7305 | 456/18723 | 9.76e-10 | 2.40e-08 | 241 |
GO:19033227 | Oral cavity | OSCC | positive regulation of protein modification by small protein conjugation or removal | 88/7305 | 138/18723 | 3.24e-09 | 7.39e-08 | 88 |
GO:00718979 | Oral cavity | OSCC | DNA biosynthetic process | 106/7305 | 180/18723 | 4.86e-08 | 8.95e-07 | 106 |
GO:00313986 | Oral cavity | OSCC | positive regulation of protein ubiquitination | 75/7305 | 119/18723 | 9.46e-08 | 1.65e-06 | 75 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPRTN | SNV | Missense_Mutation | rs143558208 | c.502C>T | p.Arg168Cys | p.R168C | Q9H040 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A7-A2KD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
SPRTN | SNV | Missense_Mutation | c.1383N>A | p.Asn461Lys | p.N461K | Q9H040 | protein_coding | tolerated(0.35) | benign(0) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPRTN | SNV | Missense_Mutation | rs761874937 | c.541N>A | p.Gly181Ser | p.G181S | Q9H040 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPRTN | SNV | Missense_Mutation | rs145727605 | c.491G>A | p.Arg164Gln | p.R164Q | Q9H040 | protein_coding | tolerated(1) | benign(0.007) | TCGA-AO-A12D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
SPRTN | SNV | Missense_Mutation | c.1094N>G | p.Ser365Cys | p.S365C | Q9H040 | protein_coding | deleterious(0.02) | possibly_damaging(0.819) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
SPRTN | SNV | Missense_Mutation | c.419N>A | p.Arg140His | p.R140H | Q9H040 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-OL-A97C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SPRTN | SNV | Missense_Mutation | novel | c.446N>A | p.Ile149Lys | p.I149K | Q9H040 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPRTN | SNV | Missense_Mutation | c.61N>A | p.Glu21Lys | p.E21K | Q9H040 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SPRTN | SNV | Missense_Mutation | c.419N>A | p.Arg140His | p.R140H | Q9H040 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
SPRTN | SNV | Missense_Mutation | novel | c.88N>C | p.Ser30Pro | p.S30P | Q9H040 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |