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Gene: SNTB1 |
Gene summary for SNTB1 |
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Gene information | Species | Human | Gene symbol | SNTB1 | Gene ID | 6641 |
Gene name | syntrophin beta 1 | |
Gene Alias | 59-DAP | |
Cytomap | 8q24.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q13884 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6641 | SNTB1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.74e-06 | -3.85e-01 | 0.0215 |
6641 | SNTB1 | HCC1 | Human | Liver | HCC | 3.25e-12 | 3.53e+00 | 0.5336 |
6641 | SNTB1 | HCC2 | Human | Liver | HCC | 5.36e-25 | 4.52e+00 | 0.5341 |
6641 | SNTB1 | Pt13.a | Human | Liver | HCC | 2.56e-15 | -1.66e-01 | 0.021 |
6641 | SNTB1 | Pt13.b | Human | Liver | HCC | 1.33e-38 | -4.66e-02 | 0.0251 |
6641 | SNTB1 | Pt14.a | Human | Liver | HCC | 1.43e-10 | 9.81e-02 | 0.0169 |
6641 | SNTB1 | Pt14.b | Human | Liver | HCC | 8.81e-06 | -1.89e-01 | 0.018 |
6641 | SNTB1 | Pt14.d | Human | Liver | HCC | 3.56e-11 | -2.94e-01 | 0.0143 |
6641 | SNTB1 | S014 | Human | Liver | HCC | 2.05e-36 | 1.69e+00 | 0.2254 |
6641 | SNTB1 | S015 | Human | Liver | HCC | 1.90e-22 | 1.48e+00 | 0.2375 |
6641 | SNTB1 | S016 | Human | Liver | HCC | 3.37e-30 | 1.46e+00 | 0.2243 |
6641 | SNTB1 | S027 | Human | Liver | HCC | 3.45e-11 | 1.40e+00 | 0.2446 |
6641 | SNTB1 | S028 | Human | Liver | HCC | 1.85e-27 | 1.52e+00 | 0.2503 |
6641 | SNTB1 | S029 | Human | Liver | HCC | 2.09e-20 | 1.57e+00 | 0.2581 |
6641 | SNTB1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 9.91e-09 | 5.54e-01 | -0.2116 |
6641 | SNTB1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.54e-04 | 6.45e-01 | -0.1941 |
6641 | SNTB1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 6.83e-10 | 6.80e-01 | -0.2119 |
6641 | SNTB1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 9.53e-13 | 9.77e-01 | 0.1829 |
6641 | SNTB1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 5.27e-11 | 9.17e-01 | 0.1835 |
6641 | SNTB1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.38e-17 | 1.06e+00 | 0.1859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:00030121 | Colorectum | MSS | muscle system process | 105/3467 | 452/18723 | 6.39e-03 | 4.26e-02 | 105 |
GO:00030122 | Colorectum | FAP | muscle system process | 89/2622 | 452/18723 | 4.63e-04 | 5.39e-03 | 89 |
GO:00030123 | Colorectum | CRC | muscle system process | 74/2078 | 452/18723 | 3.92e-04 | 5.80e-03 | 74 |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
GO:000301211 | Lung | AIS | muscle system process | 63/1849 | 452/18723 | 3.18e-03 | 3.05e-02 | 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNTB1 | SNV | Missense_Mutation | novel | c.328N>C | p.Lys110Gln | p.K110Q | Q13884 | protein_coding | tolerated(0.07) | probably_damaging(0.969) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNTB1 | SNV | Missense_Mutation | rs199549031 | c.1199N>T | p.Thr400Met | p.T400M | Q13884 | protein_coding | deleterious(0.02) | possibly_damaging(0.904) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
SNTB1 | SNV | Missense_Mutation | rs746819066 | c.355N>C | p.Glu119Gln | p.E119Q | Q13884 | protein_coding | deleterious(0.01) | possibly_damaging(0.838) | TCGA-BH-A0DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
SNTB1 | SNV | Missense_Mutation | c.919G>A | p.Glu307Lys | p.E307K | Q13884 | protein_coding | deleterious(0) | possibly_damaging(0.566) | TCGA-C8-A1HE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNTB1 | SNV | Missense_Mutation | c.884N>G | p.Ser295Cys | p.S295C | Q13884 | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SNTB1 | SNV | Missense_Mutation | rs772200241 | c.775G>A | p.Asp259Asn | p.D259N | Q13884 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNTB1 | SNV | Missense_Mutation | c.1589N>G | p.Lys530Arg | p.K530R | Q13884 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNTB1 | SNV | Missense_Mutation | c.1610T>C | p.Val537Ala | p.V537A | Q13884 | protein_coding | deleterious(0) | benign(0.269) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SNTB1 | SNV | Missense_Mutation | rs754847025 | c.133G>A | p.Ala45Thr | p.A45T | Q13884 | protein_coding | tolerated(0.84) | benign(0.025) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SNTB1 | SNV | Missense_Mutation | rs749144227 | c.1439A>C | p.Gln480Pro | p.Q480P | Q13884 | protein_coding | deleterious(0.03) | possibly_damaging(0.514) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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