![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SNRPG |
Gene summary for SNRPG |
![]() |
Gene information | Species | Human | Gene symbol | SNRPG | Gene ID | 6637 |
Gene name | small nuclear ribonucleoprotein polypeptide G | |
Gene Alias | SMG | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | C9JVQ0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6637 | SNRPG | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.37e-03 | 2.92e-01 | -0.1808 |
6637 | SNRPG | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.93e-08 | 3.73e-01 | -0.0811 |
6637 | SNRPG | HTA11_347_2000001011 | Human | Colorectum | AD | 2.83e-07 | 2.49e-01 | -0.1954 |
6637 | SNRPG | HTA11_83_2000001011 | Human | Colorectum | SER | 1.65e-03 | 3.31e-01 | -0.1526 |
6637 | SNRPG | HTA11_696_2000001011 | Human | Colorectum | AD | 6.02e-04 | 2.60e-01 | -0.1464 |
6637 | SNRPG | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.88e-12 | 5.14e-01 | -0.059 |
6637 | SNRPG | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.69e-03 | 3.13e-01 | -0.1706 |
6637 | SNRPG | HTA11_546_2000001011 | Human | Colorectum | AD | 1.74e-02 | 2.16e-01 | -0.0842 |
6637 | SNRPG | HTA11_866_3004761011 | Human | Colorectum | AD | 2.05e-07 | 2.68e-01 | 0.096 |
6637 | SNRPG | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.56e-04 | 3.52e-01 | 0.0528 |
6637 | SNRPG | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.81e-06 | 4.11e-01 | 0.0131 |
6637 | SNRPG | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.32e-02 | 1.94e-01 | -0.0177 |
6637 | SNRPG | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.26e-06 | 3.54e-01 | 0.0112 |
6637 | SNRPG | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.52e-05 | 3.41e-01 | 0.0588 |
6637 | SNRPG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.64e-16 | 6.02e-01 | 0.294 |
6637 | SNRPG | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.21e-05 | 1.02e+00 | 0.3487 |
6637 | SNRPG | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.31e-15 | 5.58e-01 | 0.3859 |
6637 | SNRPG | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.98e-03 | 2.98e-01 | 0.2585 |
6637 | SNRPG | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.59e-09 | 3.59e-01 | 0.3005 |
6637 | SNRPG | A002-C-116 | Human | Colorectum | FAP | 3.61e-02 | -6.21e-02 | -0.0452 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003873 | Breast | Precancer | spliceosomal snRNP assembly | 10/1080 | 50/18723 | 4.86e-04 | 6.35e-03 | 10 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:007182614 | Breast | IDC | ribonucleoprotein complex subunit organization | 52/1434 | 227/18723 | 5.18e-13 | 1.21e-10 | 52 |
GO:002261814 | Breast | IDC | ribonucleoprotein complex assembly | 51/1434 | 220/18723 | 5.32e-13 | 1.21e-10 | 51 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000038711 | Breast | IDC | spliceosomal snRNP assembly | 11/1434 | 50/18723 | 1.18e-03 | 1.28e-02 | 11 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:007182624 | Breast | DCIS | ribonucleoprotein complex subunit organization | 52/1390 | 227/18723 | 1.54e-13 | 3.95e-11 | 52 |
GO:002261824 | Breast | DCIS | ribonucleoprotein complex assembly | 51/1390 | 220/18723 | 1.60e-13 | 3.95e-11 | 51 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRPG | SNV | Missense_Mutation | novel | c.173G>A | p.Gly58Glu | p.G58E | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
SNRPG | SNV | Missense_Mutation | c.45N>C | p.Lys15Asn | p.K15N | protein_coding | deleterious(0.01) | probably_damaging(0.955) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | ||
SNRPG | SNV | Missense_Mutation | rs114478765 | c.200C>T | p.Ala67Val | p.A67V | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SNRPG | SNV | Missense_Mutation | rs753363451 | c.146N>T | p.Ala49Val | p.A49V | protein_coding | tolerated(0.2) | benign(0.061) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SNRPG | SNV | Missense_Mutation | novel | c.112A>G | p.Met38Val | p.M38V | protein_coding | deleterious(0.02) | benign(0.247) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPG | SNV | Missense_Mutation | rs753363451 | c.146N>T | p.Ala49Val | p.A49V | protein_coding | tolerated(0.2) | benign(0.061) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNRPG | SNV | Missense_Mutation | c.14A>G | p.His5Arg | p.H5R | protein_coding | deleterious(0.03) | possibly_damaging(0.735) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
SNRPG | SNV | Missense_Mutation | novel | c.177G>T | p.Met59Ile | p.M59I | protein_coding | deleterious(0.03) | benign(0.411) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPG | SNV | Missense_Mutation | rs114478765 | c.200N>T | p.Ala67Val | p.A67V | protein_coding | tolerated(1) | benign(0) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNRPG | SNV | Missense_Mutation | novel | c.15N>G | p.His5Gln | p.H5Q | protein_coding | tolerated(0.2) | benign(0.318) | TCGA-KK-A7AY-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |