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Gene: SNRNP25 |
Gene summary for SNRNP25 |
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Gene information | Species | Human | Gene symbol | SNRNP25 | Gene ID | 79622 |
Gene name | small nuclear ribonucleoprotein U11/U12 subunit 25 | |
Gene Alias | C16orf33 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9BV90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79622 | SNRNP25 | P28T-E | Human | Esophagus | ESCC | 3.26e-29 | 6.15e-01 | 0.1149 |
79622 | SNRNP25 | P30T-E | Human | Esophagus | ESCC | 5.78e-17 | 8.25e-01 | 0.137 |
79622 | SNRNP25 | P31T-E | Human | Esophagus | ESCC | 5.76e-20 | 4.12e-01 | 0.1251 |
79622 | SNRNP25 | P32T-E | Human | Esophagus | ESCC | 1.60e-54 | 1.17e+00 | 0.1666 |
79622 | SNRNP25 | P36T-E | Human | Esophagus | ESCC | 3.31e-20 | 7.42e-01 | 0.1187 |
79622 | SNRNP25 | P37T-E | Human | Esophagus | ESCC | 4.12e-33 | 9.43e-01 | 0.1371 |
79622 | SNRNP25 | P38T-E | Human | Esophagus | ESCC | 3.20e-04 | 2.37e-01 | 0.127 |
79622 | SNRNP25 | P39T-E | Human | Esophagus | ESCC | 9.40e-19 | 3.30e-01 | 0.0894 |
79622 | SNRNP25 | P40T-E | Human | Esophagus | ESCC | 1.20e-06 | 3.44e-01 | 0.109 |
79622 | SNRNP25 | P42T-E | Human | Esophagus | ESCC | 3.88e-18 | 5.28e-01 | 0.1175 |
79622 | SNRNP25 | P44T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.89e-01 | 0.1096 |
79622 | SNRNP25 | P47T-E | Human | Esophagus | ESCC | 1.84e-16 | 3.54e-01 | 0.1067 |
79622 | SNRNP25 | P48T-E | Human | Esophagus | ESCC | 2.13e-19 | 4.24e-01 | 0.0959 |
79622 | SNRNP25 | P49T-E | Human | Esophagus | ESCC | 6.35e-06 | 1.15e+00 | 0.1768 |
79622 | SNRNP25 | P52T-E | Human | Esophagus | ESCC | 8.92e-48 | 1.07e+00 | 0.1555 |
79622 | SNRNP25 | P54T-E | Human | Esophagus | ESCC | 6.95e-27 | 7.57e-01 | 0.0975 |
79622 | SNRNP25 | P56T-E | Human | Esophagus | ESCC | 7.41e-05 | 7.76e-01 | 0.1613 |
79622 | SNRNP25 | P57T-E | Human | Esophagus | ESCC | 1.96e-21 | 4.73e-01 | 0.0926 |
79622 | SNRNP25 | P61T-E | Human | Esophagus | ESCC | 1.07e-10 | 3.98e-01 | 0.099 |
79622 | SNRNP25 | P62T-E | Human | Esophagus | ESCC | 2.28e-24 | 6.52e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:000037524 | Breast | DCIS | RNA splicing, via transesterification reactions | 58/1390 | 324/18723 | 2.89e-10 | 3.34e-08 | 58 |
GO:000037724 | Breast | DCIS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:000039824 | Breast | DCIS | mRNA splicing, via spliceosome | 57/1390 | 320/18723 | 5.01e-10 | 5.35e-08 | 57 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRNP25 | SNV | Missense_Mutation | novel | c.241G>A | p.Glu81Lys | p.E81K | Q9BV90 | protein_coding | tolerated(0.15) | benign(0.164) | TCGA-MU-A8JM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SNRNP25 | SNV | Missense_Mutation | rs747117068 | c.112G>A | p.Gly38Ser | p.G38S | Q9BV90 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SNRNP25 | SNV | Missense_Mutation | c.239G>A | p.Arg80His | p.R80H | Q9BV90 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNRNP25 | SNV | Missense_Mutation | c.201N>T | p.Lys67Asn | p.K67N | Q9BV90 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SNRNP25 | SNV | Missense_Mutation | rs770187197 | c.364N>A | p.Glu122Lys | p.E122K | Q9BV90 | protein_coding | tolerated(0.19) | benign(0.308) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SNRNP25 | SNV | Missense_Mutation | rs779593421 | c.287N>G | p.Tyr96Cys | p.Y96C | Q9BV90 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNRNP25 | SNV | Missense_Mutation | novel | c.4N>A | p.Asp2Asn | p.D2N | Q9BV90 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNRNP25 | SNV | Missense_Mutation | novel | c.141N>C | p.Lys47Asn | p.K47N | Q9BV90 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-33-A5GW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNRNP25 | SNV | Missense_Mutation | rs761819954 | c.56N>G | p.Asp19Gly | p.D19G | Q9BV90 | protein_coding | tolerated(0.23) | benign(0.245) | TCGA-CR-7377-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNRNP25 | SNV | Missense_Mutation | rs762979091 | c.373N>C | p.Phe125Leu | p.F125L | Q9BV90 | protein_coding | deleterious(0.04) | probably_damaging(0.963) | TCGA-MT-A51W-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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