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Gene: SMIM30 |
Gene summary for SMIM30 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SMIM30 | Gene ID | 401397 |
| Gene name | small integral membrane protein 30 | |
| Gene Alias | LINC00998 | |
| Cytomap | 7q31.1 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 401397 | SMIM30 | PTC05 | Human | Thyroid | PTC | 1.02e-26 | 9.68e-01 | 0.2065 |
| 401397 | SMIM30 | PTC06 | Human | Thyroid | PTC | 5.02e-46 | 8.74e-01 | 0.2057 |
| 401397 | SMIM30 | PTC07 | Human | Thyroid | PTC | 1.21e-51 | 8.34e-01 | 0.2044 |
| 401397 | SMIM30 | ATC09 | Human | Thyroid | ATC | 9.00e-08 | 3.31e-01 | 0.2871 |
| 401397 | SMIM30 | ATC11 | Human | Thyroid | ATC | 9.94e-09 | 5.05e-01 | 0.3386 |
| 401397 | SMIM30 | ATC12 | Human | Thyroid | ATC | 1.68e-15 | 3.82e-01 | 0.34 |
| 401397 | SMIM30 | ATC13 | Human | Thyroid | ATC | 7.43e-16 | 2.95e-01 | 0.34 |
| 401397 | SMIM30 | ATC1 | Human | Thyroid | ATC | 7.57e-09 | 3.83e-01 | 0.2878 |
| 401397 | SMIM30 | ATC2 | Human | Thyroid | ATC | 4.17e-22 | 1.51e+00 | 0.34 |
| 401397 | SMIM30 | ATC3 | Human | Thyroid | ATC | 5.97e-08 | 3.73e-01 | 0.338 |
| 401397 | SMIM30 | ATC4 | Human | Thyroid | ATC | 5.41e-21 | 5.16e-01 | 0.34 |
| 401397 | SMIM30 | ATC5 | Human | Thyroid | ATC | 7.43e-16 | 3.17e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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