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Gene: SMIM15 |
Gene summary for SMIM15 |
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Gene information | Species | Human | Gene symbol | SMIM15 | Gene ID | 643155 |
Gene name | small integral membrane protein 15 | |
Gene Alias | C5orf43 | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q7Z3B0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
643155 | SMIM15 | P42T-E | Human | Esophagus | ESCC | 1.10e-15 | 3.29e-01 | 0.1175 |
643155 | SMIM15 | P44T-E | Human | Esophagus | ESCC | 2.78e-16 | 3.99e-01 | 0.1096 |
643155 | SMIM15 | P47T-E | Human | Esophagus | ESCC | 2.10e-14 | 3.63e-01 | 0.1067 |
643155 | SMIM15 | P48T-E | Human | Esophagus | ESCC | 4.88e-17 | 3.62e-01 | 0.0959 |
643155 | SMIM15 | P49T-E | Human | Esophagus | ESCC | 4.38e-12 | 1.36e+00 | 0.1768 |
643155 | SMIM15 | P52T-E | Human | Esophagus | ESCC | 2.21e-25 | 8.77e-01 | 0.1555 |
643155 | SMIM15 | P54T-E | Human | Esophagus | ESCC | 8.90e-26 | 6.45e-01 | 0.0975 |
643155 | SMIM15 | P56T-E | Human | Esophagus | ESCC | 4.92e-09 | 1.27e+00 | 0.1613 |
643155 | SMIM15 | P57T-E | Human | Esophagus | ESCC | 1.10e-14 | 3.78e-01 | 0.0926 |
643155 | SMIM15 | P61T-E | Human | Esophagus | ESCC | 5.84e-16 | 4.75e-01 | 0.099 |
643155 | SMIM15 | P62T-E | Human | Esophagus | ESCC | 4.62e-87 | 1.39e+00 | 0.1302 |
643155 | SMIM15 | P65T-E | Human | Esophagus | ESCC | 1.32e-18 | 4.13e-01 | 0.0978 |
643155 | SMIM15 | P74T-E | Human | Esophagus | ESCC | 9.68e-36 | 1.20e+00 | 0.1479 |
643155 | SMIM15 | P75T-E | Human | Esophagus | ESCC | 9.57e-60 | 1.20e+00 | 0.1125 |
643155 | SMIM15 | P76T-E | Human | Esophagus | ESCC | 9.62e-25 | 4.98e-01 | 0.1207 |
643155 | SMIM15 | P79T-E | Human | Esophagus | ESCC | 5.67e-27 | 5.25e-01 | 0.1154 |
643155 | SMIM15 | P80T-E | Human | Esophagus | ESCC | 2.49e-55 | 1.64e+00 | 0.155 |
643155 | SMIM15 | P82T-E | Human | Esophagus | ESCC | 8.95e-16 | 1.11e+00 | 0.1072 |
643155 | SMIM15 | P83T-E | Human | Esophagus | ESCC | 9.85e-45 | 1.25e+00 | 0.1738 |
643155 | SMIM15 | P84T-E | Human | Esophagus | ESCC | 2.17e-09 | 5.45e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM15 | SNV | Missense_Mutation | rs201138177 | c.181C>T | p.Arg61Cys | p.R61C | Q7Z3B0 | protein_coding | tolerated(0.2) | possibly_damaging(0.656) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.140N>C | p.Met47Thr | p.M47T | Q7Z3B0 | protein_coding | tolerated(0.21) | benign(0.017) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.8N>C | p.Asp3Ala | p.D3A | Q7Z3B0 | protein_coding | deleterious(0.04) | benign(0.325) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.67N>A | p.Leu23Ile | p.L23I | Q7Z3B0 | protein_coding | tolerated(0.23) | probably_damaging(0.978) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.51N>T | p.Lys17Asn | p.K17N | Q7Z3B0 | protein_coding | tolerated(0.09) | benign(0.052) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.116N>C | p.Val39Ala | p.V39A | Q7Z3B0 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.219N>T | p.Lys73Asn | p.K73N | Q7Z3B0 | protein_coding | tolerated(0.08) | probably_damaging(0.991) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SMIM15 | SNV | Missense_Mutation | novel | c.156N>T | p.Glu52Asp | p.E52D | Q7Z3B0 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMIM15 | SNV | Missense_Mutation | c.28N>C | p.Tyr10His | p.Y10H | Q7Z3B0 | protein_coding | tolerated(0.15) | probably_damaging(0.994) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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