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Gene: SLC7A11 |
Gene summary for SLC7A11 |
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Gene information | Species | Human | Gene symbol | SLC7A11 | Gene ID | 23657 |
Gene name | solute carrier family 7 member 11 | |
Gene Alias | CCBR1 | |
Cytomap | 4q28.3 | |
Gene Type | protein-coding | GO ID | GO:0000096 | UniProtAcc | Q9UPY5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23657 | SLC7A11 | C08 | Human | Oral cavity | OSCC | 6.26e-28 | 7.41e-01 | 0.1919 |
23657 | SLC7A11 | SYSMH1 | Human | Oral cavity | OSCC | 2.14e-37 | 8.33e-01 | 0.1127 |
23657 | SLC7A11 | SYSMH3 | Human | Oral cavity | OSCC | 8.07e-10 | 3.92e-01 | 0.2442 |
23657 | SLC7A11 | 048752_1579-all-cells | Human | Prostate | BPH | 4.45e-39 | 9.86e-01 | 0.1008 |
23657 | SLC7A11 | 052097_1595-all-cells | Human | Prostate | BPH | 1.05e-35 | 9.02e-01 | 0.0972 |
23657 | SLC7A11 | 052099_1652-all-cells | Human | Prostate | BPH | 2.30e-09 | 5.03e-01 | 0.1038 |
23657 | SLC7A11 | Dong_P5 | Human | Prostate | Tumor | 2.89e-11 | 2.64e-02 | 0.053 |
23657 | SLC7A11 | PTC01 | Human | Thyroid | PTC | 1.02e-02 | 1.13e-02 | 0.1899 |
23657 | SLC7A11 | PTC06 | Human | Thyroid | PTC | 1.13e-04 | 2.07e-01 | 0.2057 |
23657 | SLC7A11 | ATC11 | Human | Thyroid | ATC | 2.43e-09 | 9.46e-01 | 0.3386 |
23657 | SLC7A11 | ATC12 | Human | Thyroid | ATC | 1.63e-13 | 4.12e-01 | 0.34 |
23657 | SLC7A11 | ATC13 | Human | Thyroid | ATC | 2.03e-02 | 4.40e-02 | 0.34 |
23657 | SLC7A11 | ATC2 | Human | Thyroid | ATC | 1.28e-04 | 8.73e-01 | 0.34 |
23657 | SLC7A11 | ATC3 | Human | Thyroid | ATC | 1.79e-15 | 9.36e-01 | 0.338 |
23657 | SLC7A11 | ATC4 | Human | Thyroid | ATC | 5.81e-16 | 5.78e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:00423986 | Esophagus | ESCC | cellular modified amino acid biosynthetic process | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421641 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0421651 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0421620 | Oral cavity | OSCC | Ferroptosis | 29/3704 | 41/8465 | 4.26e-04 | 1.30e-03 | 6.60e-04 | 29 |
hsa04216110 | Oral cavity | OSCC | Ferroptosis | 29/3704 | 41/8465 | 4.26e-04 | 1.30e-03 | 6.60e-04 | 29 |
hsa0421626 | Prostate | Tumor | Ferroptosis | 24/1791 | 41/8465 | 1.94e-07 | 2.14e-06 | 1.33e-06 | 24 |
hsa0421636 | Prostate | Tumor | Ferroptosis | 24/1791 | 41/8465 | 1.94e-07 | 2.14e-06 | 1.33e-06 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A11 | SNV | Missense_Mutation | novel | c.1412A>G | p.Asp471Gly | p.D471G | Q9UPY5 | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.1483N>A | p.Val495Ile | p.V495I | Q9UPY5 | protein_coding | tolerated(0.29) | benign(0.018) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
SLC7A11 | SNV | Missense_Mutation | novel | c.538N>C | p.Asn180His | p.N180H | Q9UPY5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
SLC7A11 | SNV | Missense_Mutation | novel | c.197C>T | p.Pro66Leu | p.P66L | Q9UPY5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SLC7A11 | SNV | Missense_Mutation | c.787N>A | p.Glu263Lys | p.E263K | Q9UPY5 | protein_coding | tolerated(0.1) | benign(0.101) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC7A11 | SNV | Missense_Mutation | rs760898836 | c.959N>T | p.Pro320Leu | p.P320L | Q9UPY5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC7A11 | SNV | Missense_Mutation | novel | c.854N>T | p.Asn285Ile | p.N285I | Q9UPY5 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC7A11 | SNV | Missense_Mutation | c.802N>A | p.Leu268Ile | p.L268I | Q9UPY5 | protein_coding | deleterious(0.01) | possibly_damaging(0.53) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A11 | SNV | Missense_Mutation | c.167C>T | p.Thr56Ile | p.T56I | Q9UPY5 | protein_coding | deleterious(0.02) | benign(0.085) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A11 | SNV | Missense_Mutation | novel | c.941N>C | p.Asn314Thr | p.N314T | Q9UPY5 | protein_coding | tolerated(0.73) | benign(0.027) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23657 | SLC7A11 | TRANSPORTER, DRUGGABLE GENOME, CELL SURFACE | RILUZOLE | RILUZOLE | ||
23657 | SLC7A11 | TRANSPORTER, DRUGGABLE GENOME, CELL SURFACE | inhibitor | 135650876 | QUISQUALATE |
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