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Gene: SLC5A6 |
Gene summary for SLC5A6 |
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Gene information | Species | Human | Gene symbol | SLC5A6 | Gene ID | 8884 |
Gene name | solute carrier family 5 member 6 | |
Gene Alias | NERIB | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9HD19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8884 | SLC5A6 | P52T-E | Human | Esophagus | ESCC | 1.78e-14 | 3.35e-01 | 0.1555 |
8884 | SLC5A6 | P54T-E | Human | Esophagus | ESCC | 1.10e-14 | 3.28e-01 | 0.0975 |
8884 | SLC5A6 | P57T-E | Human | Esophagus | ESCC | 3.73e-07 | 1.38e-01 | 0.0926 |
8884 | SLC5A6 | P61T-E | Human | Esophagus | ESCC | 3.69e-11 | 2.85e-01 | 0.099 |
8884 | SLC5A6 | P62T-E | Human | Esophagus | ESCC | 7.51e-11 | 2.83e-01 | 0.1302 |
8884 | SLC5A6 | P74T-E | Human | Esophagus | ESCC | 2.59e-07 | 2.01e-01 | 0.1479 |
8884 | SLC5A6 | P75T-E | Human | Esophagus | ESCC | 4.45e-08 | 1.48e-01 | 0.1125 |
8884 | SLC5A6 | P76T-E | Human | Esophagus | ESCC | 1.54e-14 | 2.66e-01 | 0.1207 |
8884 | SLC5A6 | P79T-E | Human | Esophagus | ESCC | 2.19e-14 | 4.54e-01 | 0.1154 |
8884 | SLC5A6 | P80T-E | Human | Esophagus | ESCC | 3.24e-27 | 7.41e-01 | 0.155 |
8884 | SLC5A6 | P82T-E | Human | Esophagus | ESCC | 8.67e-04 | 3.83e-01 | 0.1072 |
8884 | SLC5A6 | P83T-E | Human | Esophagus | ESCC | 1.07e-21 | 8.48e-01 | 0.1738 |
8884 | SLC5A6 | P89T-E | Human | Esophagus | ESCC | 4.35e-07 | 4.44e-01 | 0.1752 |
8884 | SLC5A6 | P107T-E | Human | Esophagus | ESCC | 5.21e-10 | 3.98e-01 | 0.171 |
8884 | SLC5A6 | P127T-E | Human | Esophagus | ESCC | 7.76e-07 | 8.77e-02 | 0.0826 |
8884 | SLC5A6 | P128T-E | Human | Esophagus | ESCC | 5.47e-14 | 5.73e-01 | 0.1241 |
8884 | SLC5A6 | P130T-E | Human | Esophagus | ESCC | 2.97e-32 | 6.63e-01 | 0.1676 |
8884 | SLC5A6 | HCC1_Meng | Human | Liver | HCC | 2.11e-51 | 1.22e-01 | 0.0246 |
8884 | SLC5A6 | HCC1 | Human | Liver | HCC | 8.14e-24 | 5.40e+00 | 0.5336 |
8884 | SLC5A6 | HCC2 | Human | Liver | HCC | 1.63e-22 | 3.81e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0150104 | Colorectum | MSS | transport across blood-brain barrier | 28/3467 | 87/18723 | 1.54e-03 | 1.41e-02 | 28 |
GO:0010232 | Colorectum | MSS | vascular transport | 28/3467 | 88/18723 | 1.87e-03 | 1.64e-02 | 28 |
GO:00428861 | Colorectum | MSS | amide transport | 76/3467 | 301/18723 | 2.14e-03 | 1.80e-02 | 76 |
GO:00068141 | Colorectum | CRC | sodium ion transport | 49/2078 | 245/18723 | 3.01e-05 | 7.86e-04 | 49 |
GO:00030181 | Colorectum | CRC | vascular process in circulatory system | 45/2078 | 263/18723 | 2.10e-03 | 2.08e-02 | 45 |
GO:01501042 | Colorectum | CRC | transport across blood-brain barrier | 18/2078 | 87/18723 | 6.50e-03 | 4.69e-02 | 18 |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC5A6 | SNV | Missense_Mutation | c.700N>C | p.Val234Leu | p.V234L | Q9Y289 | protein_coding | tolerated(0.84) | benign(0.061) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
SLC5A6 | SNV | Missense_Mutation | rs775950585 | c.1774N>A | p.Asp592Asn | p.D592N | Q9Y289 | protein_coding | tolerated(0.12) | benign(0.115) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC5A6 | SNV | Missense_Mutation | c.131N>G | p.Leu44Arg | p.L44R | Q9Y289 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC5A6 | SNV | Missense_Mutation | novel | c.575N>A | p.Ala192Asp | p.A192D | Q9Y289 | protein_coding | deleterious(0) | benign(0.261) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
SLC5A6 | SNV | Missense_Mutation | c.1231C>G | p.Leu411Val | p.L411V | Q9Y289 | protein_coding | tolerated(0.08) | possibly_damaging(0.456) | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR | |
SLC5A6 | insertion | Frame_Shift_Ins | novel | c.1768_1769insGA | p.His590ArgfsTer63 | p.H590Rfs*63 | Q9Y289 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC5A6 | insertion | Nonsense_Mutation | novel | c.1767_1768insTAAAAAAAAAAAATAAAAATAAA | p.His590Ter | p.H590* | Q9Y289 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC5A6 | SNV | Missense_Mutation | c.757C>T | p.Arg253Trp | p.R253W | Q9Y289 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SLC5A6 | SNV | Missense_Mutation | c.1566N>G | p.Phe522Leu | p.F522L | Q9Y289 | protein_coding | tolerated(0.66) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SLC5A6 | SNV | Missense_Mutation | novel | c.1265N>A | p.Pro422His | p.P422H | Q9Y289 | protein_coding | deleterious(0.04) | possibly_damaging(0.852) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8884 | SLC5A6 | EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME, TRANSPORTER | Gabapentin enacarbil |
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