Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SLC25A43_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SLC25A43_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SLC25A43_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SLC25A43_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SLC25A43_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SLC25A43_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A43 | SNV | Missense_Mutation | novel | c.410N>T | p.Gln137Leu | p.Q137L | Q8WUT9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SLC25A43 | SNV | Missense_Mutation | novel | c.862N>C | p.Glu288Gln | p.E288Q | Q8WUT9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
SLC25A43 | insertion | In_Frame_Ins | novel | c.498_499insAGCCGAGATCGTGCCACTGCACTCCAGCCTGGCCAACAAAGT | p.Gly166_Val167insSerArgAspArgAlaThrAlaLeuGlnProGlyGlnGlnSer | p.G166_V167insSRDRATALQPGQQS | Q8WUT9 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
SLC25A43 | deletion | Frame_Shift_Del | | c.576_586delNNNNNNNNNNN | p.Asn193ArgfsTer11 | p.N193Rfs*11 | Q8WUT9 | protein_coding | | | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.648N>C | p.Gln216His | p.Q216H | Q8WUT9 | protein_coding | deleterious(0.03) | possibly_damaging(0.896) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SLC25A43 | SNV | Missense_Mutation | novel | c.280G>T | p.Val94Phe | p.V94F | Q8WUT9 | protein_coding | deleterious(0.01) | possibly_damaging(0.73) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC25A43 | SNV | Missense_Mutation | | c.361N>G | p.Thr121Ala | p.T121A | Q8WUT9 | protein_coding | tolerated(0.5) | benign(0.129) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | | c.875N>T | p.Arg292Ile | p.R292I | Q8WUT9 | protein_coding | deleterious(0.01) | possibly_damaging(0.55) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | | c.627N>G | p.Cys209Trp | p.C209W | Q8WUT9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F4-6806-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | irinotecan | PD |
SLC25A43 | SNV | Missense_Mutation | | c.1021N>A | p.Leu341Ile | p.L341I | Q8WUT9 | protein_coding | tolerated_low_confidence(0.06) | benign(0.014) | TCGA-AG-3727-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |